A Food Supplement with Antioxidative Santa Herba Extract Modulates Energy Metabolism and Contributes to Weight Management

Abstract

The plant Santa herba (Eriodictyon californicum) contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. The study assessed the impact of Santa herba on oxidative stress, energy metabolism, weight reduction, and eating behavior, combining in vitro models with clinical data. Santa herba binding of the adenosine receptor A2A (ADORA2A) was assessed using a radioligand binding assay. A Caenorhabditis elegans model was used to determine mobility boosting effects, and Santa herba oxygen radical absorbance capacity (ORAC) values were determined in comparison to antioxidative plants. Clinical data, that is, body weight and appetite-related parameters, were obtained from overweight and obese women receiving either Santa herba or placebo for 12 weeks. Results showed that Santa herba extract binds to ADORA2A, stimulates C. elegans motility (+7.5%) and locomotion, and yields high antioxidative capacities (ORAC: 819 trolox equivalent). Clinical data, obtained from 24 overweight and 25 obese women (mean: 47.5 years), demonstrated a reduced body weight (P = .042) and body fat (P = .044), and by trend reduced leptin levels (P = .065) in women with obesity after Santa herba consumption compared to placebo. In conclusion, Santa herba extract has energizing and antioxidative properties and may aid in weight management of people with obesity. ClinicalTrials.gov Identifier: NCT03853603.

Up-Cycling of Olea europaea L. Ancient Cultivars Side Products: Study of a Combined Cosmetic–Food Supplement Treatment Based on Leaves and Olive Mill Wastewater Extracts

“…As shown in Table 4, the PCL values for cosmetic formulations were considerably high in reference to other formulations previously investigated by us [25][26][27]. Similar observations can be made for ORAC values of the biophenols extract, and this also indicates good antioxidant activity, in particular when it is compared with other plant extracts studied by the same research group [28,29] or compared with recent literature data on food supplements [30].…”

The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation

“…In addition, we performed the ORAC assay, which measures the ability of a substance to inhibit the peroxyl-radical induced oxidation. The result showed an ORAC value of 8.42 ± 0.24 µM TE/mg of Sabroxy indicating a high level of antioxidant activity similar to that of other supplements like resveratrol (8.6 µM TE/mg), green tea (13.814 µM TE/mg) [ 24 ], and Santa herba (8.19 µM/mg) [ 25 ].…”

A review on the potential use of natural products in overweight and obesity

“…with rich flavonoids (400 mg) orally ingested as capsules for 12 weeks twice daily reduced body weight and body fat and by trend reduced leptin levels compared with placebo, which might due to its energizing and antioxidative properties. The results also showed no serious adverse events occurred and all subjects rated Santa herba extract as "well tolerated" (Yvonne Mödinger, Wilhelm, Pickel, & Grothe, 2021).…”