Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome

Zia, Afaf; Hakim, Seema; Khan, Asad; Bey, Afshan; Ateeq, Hira; Parveen, Shazia; Khalid, Saifullah; Yusufi, FNK.

doi:10.1007/s00774-021-01302-6

Cited by 7 publications

(5 citation statements)

References 51 publications

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“…This longitudinal prospective study enrolled 60 female patients after screening 500 females 18-45 years. This study is in continuation with a prior study done by Zia et al [35] (2022) Patients coming to the outpatient department of the Department of Periodontics and Community Dentistry, Dr. Ziauddin Ahmad Dental College and Hospital, AMU, Aligarh, India, between November 2018 and January 2020 were recruited for the study. The patients were divided into two groups after recruitment: Control group who are periodontally and systemically healthy (N) (n = 20) and test group which included subjects with chronic periodontitis (CP) (n = 40) (Fig.…”

Section: Study Populationmentioning

confidence: 63%

Effect of non-surgical periodontal therapy on salivary and serum bone turnover markers in periodontitis

Javed

Zia²,

Khan

et al. 2023

Preprint

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Objective: Determining whether non-surgical periodontal therapy (NSPT) will affect bone turnover biomarkers (BTMs) concentration in individuals with periodontitis. Materials and Methods: 60 females aged 18-45 years were divided into two groups Normal (N) (n= 20) and Chronic periodontitis (CP) (n= 40) after recruitment. Participants with periodontitis were assigned (NSPT). Full mouth clinical periodontal parameters, salivary and serum BTMs including C-terminal telopeptides of type I collagen (CTX), bone alkaline phosphatase (BALP), and Osteoprotegerin (OPG) were recorded for both groups and 21 days and 3 months after NSPT. Results: Except for BALP_ SER (p<0.023), all variables had highly significant differences (p<0.001). Except for CP (21 days) vs. CP (3 months), groups showed significantly greater levels of PI, PPD and CAL. Correlations between BTMs and periodontal measurements were weak to moderate after NSPT. The multiple linear regression model explained 46.7% of the total variability for PI, 50.1% for PPD, 54.1% for CAL and 29.3% for GI signifying association with BTMs among groups Conclusion: Our research showed the concentration of BTMs is greatly impacted by NSPT demonstrating the significance of NSPT on bone health in periodontitis. Additionally, we discovered that serum instead of salivary samples can be utilized as a diagnostic tool to measure BTMs concentration. Clinical Relevance- This study emphasizes the significance of regular periodontal evaluation and the use of non-surgical periodontal therapy (NSPT) to manage periodontitis and prevent further bone loss. It also highlights the value of using serum samples as a diagnostic tool to monitor bone health in periodontitis patients.

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Section: Study Populationmentioning

confidence: 63%

Effect of non-surgical periodontal therapy on salivary and serum bone turnover markers in periodontitis

Javed

Zia²,

Khan

et al. 2023

Preprint

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“…Painful gums, loose teeth, and toothache are primary symptoms of periodontitis, resulting from toxins secreted by bacteria within dental plaque on the gums and nearby surfaces, eventually leading to tooth loss ( 36 ). Studies have reported that, compared to a healthy population, the plaque index in the oral cavity of PCOS patients is higher ( 37 ), with an increased susceptibility to soft tissue infections and worse periodontal conditions ( 38 – 40 ). This leads to a close association between PCOS and mouth ulcers, as well as inflammatory periodontal diseases.…”

Section: Discussionmentioning

confidence: 99%

Causal relationship between PCOS and related sex hormones with oral inflammatory diseases: a bidirectional Mendelian randomization study

Min,

Chen,

Geng

et al. 2024

Front. Endocrinol.

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BackgroundObservational studies have identified a strong association between polycystic ovary syndrome (PCOS) and hormone levels related to oral inflammatory diseases. To better understand the relationship between them, we conducted an analysis using a two-sample Mendelian randomization (MR) approach.MethodsWe gathered summary statistical data from previously published genome-wide association studies (GWAS) on PCOS and three sex hormones (AMH, Estradiol, LH) along with four oral inflammatory diseases (painful gums, loose teeth, mouth ulcers, and toothache). We selected single nucleotide polymorphisms (SNPs) as instrumental variables and employed four types of MR analysis methods to evaluate causal relationships between exposure and outcome. Finally, the robustness of our results was further validated through sensitivity tests and reverse MR.ResultsWe observed that PCOS could increase the risk of mouth ulcers (ORIVW= 1.0013, 95%CI: 1.0001-1.0025, PIVW = 0.0278), painful gums (ORIVW= 1.0015, 95%CI:1.0003-1.0027, PIVW = 0.0163), and loose teeth (ORIVW= 1.0014, 95%CI: 1.0001-1.0027, PIVW = 0.0328). Moreover, LH was also found to increase the risk of mouth ulcers (ORIVW= 1.0031, 95%CI: 0.0001-1.0062, PIVW = 0.0457). MR-Egger regression, weighted mode, and WE indicated similar results. Additionally, we discovered no causal link between PCOS and toothache (PIVW>0.05), LH and painful gums, loose teeth, or toothache (PIVW>0.05), or AMH and Estradiol level with any of the four oral diseases (PIVW>0.05).ConclusionOur research provides new insights and references for exploring the effects of PCOS and related hormones on oral inflammatory lesions. For patients with PCOS, especially those with elevated LH levels, early intervention measures should be taken to prevent the occurrence of oral inflammatory diseases.

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“…evaluated the serum levels of bone metabolism and bone turnover markers (BTMs) in PCOS accompanied with PDD. Increased level of C-terminal telopeptides of type I collagen (CTX, bone resorption marker) and decreased level of alkaline phosphatase (ALP, bone formation marker) were found in patients with comorbidity of PCOS and PDD than in patients with PDD alone ( 31 ), suggesting that PCOS worsens the bone metabolism of the alveolar bone around the periodontal tissue. In addition, PCOS enhances the levels of PD and CAL in PDD patients with continuing alveolar bone resorption ( 31 , 33 ).…”

Section: Potential Mechanisms By Which Pcos Might Increase the Risk O...mentioning

confidence: 99%

“…Poor oral hygiene and the inflammation status of gingival tissues are closely related to periodontitis. Higher PI and gingival index (GI) are observed in PCOS patients than in healthy controls ( 31 ), which indicates poor oral hygiene and soft tissue inflammation in PCOS patients. Accumulated evidence demonstrated that periodontal tissues are hormone sensitive and that gonadal hormones modulate the periodontium including fibroblasts and the epithelium ( 60 , 61 ).…”

Section: Potential Mechanisms By Which Pcos Might Increase the Risk O...mentioning

confidence: 99%

Bidirectional association between polycystic ovary syndrome and periodontal diseases

Dou

Xin²,

Zhou³

et al. 2023

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) and periodontal disease (PDD) share common risk factors. The bidirectional interaction between PCOS and PDD has been reported, but until now, the underlying molecular mechanisms remain unclear. Endocrine disorders including hyperandrogenism (HA) and insulin resistance (IR) in PCOS disturb the oral microbial composition and increase the abundance of periodontal pathogens. Additionally, PCOS has a detrimental effect on the periodontal supportive tissues, including gingiva, periodontal ligament, and alveolar bone. Systemic low-grade inflammation status, especially obesity, persistent immune imbalance, and oxidative stress induced by PCOS exacerbate the progression of PDD. Simultaneously, PDD might increase the risk of PCOS through disturbing the gut microbiota composition and inducing low-grade inflammation and oxidative stress. In addition, genetic or epigenetic predisposition and lower socioeconomic status are the common risk factors for both diseases. In this review, we will present the latest evidence of the bidirectional association between PCOS and PDD from epidemiological, mechanistic, and interventional studies. A deep understanding on their bidirectional association will be beneficial to provide novel strategies for the treatment of PCOS and PDD.

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Bone markers and bone mineral density associates with periodontitis in females with poly-cystic ovarian syndrome

Cited by 7 publications

References 51 publications

Effect of non-surgical periodontal therapy on salivary and serum bone turnover markers in periodontitis

Effect of non-surgical periodontal therapy on salivary and serum bone turnover markers in periodontitis

Causal relationship between PCOS and related sex hormones with oral inflammatory diseases: a bidirectional Mendelian randomization study

Bidirectional association between polycystic ovary syndrome and periodontal diseases

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