Bone Loss at Implant with Titanium Abutments Coated by Soda Lime Glass Containing Silver Nanoparticles: A Histological Study in the Dog

Abstract

The aim of the present study was to evaluate bone loss at implants connected to abutments coated with a soda-lime glass containing silver nanoparticles, subjected to experimental peri-implantitis. Also the aging and erosion of the coating in mouth was studied. Five beagle dogs were used in the experiments. Three implants were placed in each mandible quadrant: in 2 of them, Glass/n-Ag coated abutments were connected to implant platform, 1 was covered with a Ti-mechanized abutment. Experimental peri-implantitis was induced in all implants after the submarginal placement of cotton ligatures, and three months after animals were euthanatized. Thickness and morphology of coating was studied in abutment cross-sections by SEM. Histology and histo-morphometric studies were carried on in undecalfied ground slides. After the induced peri-implantitis: 1.The abutment coating shown losing of thickness and cracking. 2. The histometry showed a significant less bone loss in the implants with glass/n-Ag coated abutments. A more symmetric cone of bone resorption was observed in the coated group. There were no significant differences in the peri-implantitis histological characteristics between both groups of implants. Within the limits of this in-vivo study, it could be affirmed that abutments coated with biocide soda-lime-glass-silver nanoparticles can reduce bone loss in experimental peri-implantitis. This achievement makes this coating a suggestive material to control peri-implantitis development and progression.

Detection of T. forsythia and other important bacteria in crestal and subcrestal implants with ligature‐induced peri‐implant infection in dogs

“…Additionally, ligatures were kept in position during the development of inflammation. This ligature placement protocol was comparable to the conventional model in which a twelve‐week healing time was allowed . Such early stage models could be useful when the pathogenesis of peri‐implantitis was evaluated.…”

“…In the present study, peri-implant infection was induced by ligature placement, and this ligature-induced peri-implant infection animal model was widely applied in studying the pathogenesis and treatment of peri-implantitis. [22][23][24] After ligature placement, subgingival bacterial accumulation led to peri-implant soft tissue inflammation and subsequently bone loss. Additionally, ligatures were kept in position during the development of inflammation.…”

Ceramics and ceramic coatings in orthopaedics

“…Interest has focused on preparing composites which perform a dual function, serving both as a structural member (e.g., spinal fusion cage, acetabular cup, coated femoral stem), and incorporating an elutable bactericide (e.g., silver, zinc, copper, iodine, vancomycin, etc.) to prevent biofilm formation or kill planktonic bacteria [516,517]. Elutable calcium from an antimicrobial soda-lime glass-ceramic containing combeite and nepheline crystals was shown by Cabal et al to effectively resist biofilm formation from five nosocomial strains, while demonstrating excellent biocompatibility towards mesenchymal stem cells [518].…”

In vitro studies of nanosilver-doped titanium implants for oral and maxillofacial surgery

“…12 Many studies regarding SNPs have been published, [13][14][15][16][17][18] although there has been little discussion on their application in oral implantology. 19 Most of the published works lack in comprehensive evaluation of the properties of the described materials, such as roughness, 15,17,20 wettability, 15,17,21,22 or biocompatibility. [14][15][16][17] Moreover, antibacterial activities in oral applications have been evaluated only in a few studies.…”