1988
DOI: 10.1038/ki.1988.39
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Bone lead in dialysis patients

Abstract: We measured lead and calcium in multiple bone biopsies from 11 cadavers without known excessive past exposure to lead. Paired iliac crest, transiliac and tibial bone biopsies from these cadavers indicated that in bone biopsy specimens the lead/calcium ratio is more reproducible than the absolute lead concentration. There were no significant differences between the lead/calcium ratios from the iliac crest, transiliac, or tibial specimens. Transiliac bone biopsies from 35 patients (13 patients showing symptoms o… Show more

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Cited by 79 publications
(53 citation statements)
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“…Other studies also support the finding that renal dysfunction per se does not increase BLL (4,20,23,24). Chemical and histologic studies of transiliac biopsies obtained from 153 dialysis patients showed that chronic renal failure and dialysis do not cause accumulation of lead in bone (25). Moreover, the present longitudinal work demonstrates that after adjustment of other factors, including the renal function at baseline, both BLB and BLL are the most significant predictors of the progression of renal insufficiency.…”
Section: Discussionsupporting
confidence: 84%
“…Other studies also support the finding that renal dysfunction per se does not increase BLL (4,20,23,24). Chemical and histologic studies of transiliac biopsies obtained from 153 dialysis patients showed that chronic renal failure and dialysis do not cause accumulation of lead in bone (25). Moreover, the present longitudinal work demonstrates that after adjustment of other factors, including the renal function at baseline, both BLB and BLL are the most significant predictors of the progression of renal insufficiency.…”
Section: Discussionsupporting
confidence: 84%
“…In 20 and 24% of CaNa2EDTA-negative and CaNa2-EDTA-positive children, respectively, cortical bone lead values were similar to lead concentrations measured in bone biopsies from normal adults (16,17). Remarkably, an additional 40% of CaNa2EDTA-positive children had bone lead concentrations observed in industrially exposed adults (16,17). In this longitudinal study, lead-toxic children who did not qualify for treatment and other children who underwent one or two courses of CaNa2EDTA treatment were re-evaluated 6 weeks and 24 weeks postenrollment.…”
Section: Resultssupporting
confidence: 63%
“…By using net corrected LXRF counts and PbB values to predict CaNa2EDTA outcomes, the specificity and sensitivity of these two predictors were 86 and 93%, respectively (Table 5) (13). In 20 and 24% of CaNa2EDTA-negative and CaNa2-EDTA-positive children, respectively, cortical bone lead values were similar to lead concentrations measured in bone biopsies from normal adults (16,17). Remarkably, an additional 40% of CaNa2EDTA-positive children had bone lead concentrations observed in industrially exposed adults (16,17).…”
Section: Resultssupporting
confidence: 57%
“…However, in a similar study, PCA -chelatable lead was not related to the lead levels predicted by K-shell X-ray fluorescence for finger bone , while there was an association with biopsy specimens from the vertebra (14). Moreover, there were associations between CaNazEDTA-chelated lead and biopsies from the ileum (15).…”
mentioning
confidence: 83%
“…However, if we exclude both the retired worker and the one removed from active lead work (on the grounds that the lead distribution between different pools may have been different from that of currently active workers), then the correlation between calcaneus and chelated lead, for example, increases significantly, to r = 0.62 (N = 18). Recently, rather poor associations were reported between CaNa 2EDTA-chelated lead on one hand and either finger lead in patients with renal impairment (29) or tibia lead in lead workers (13) on the other, while there was a rather good correlation with lead in ileum biopsies (15).…”
Section: Skeletal Leadmentioning
confidence: 99%