Bone ingrowth in macroporous Bonelike® for orthopaedic applications

Gutierres, Manuel; Lopes, M. A.; Hussain, N. Sooraj; Lemos, A.F.; Ferreira, J.M.F.; Afonso, Américo; Cabral, Abel Trigo; Almeida, L.; Santos, J. D.

doi:10.1016/j.actbio.2007.06.009

Cited by 34 publications

(22 citation statements)

References 48 publications

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“…Moreover, Bonelike ® proved to support the adhesion, proliferation, and phenotypic expression of human endothelial cells, therefore it could be a promising candidate for pre‐endothelialization protocols in the bone tissue engineering framework . Such material was also tested in porous form to act as a scaffold for bone tissue regeneration and repair . Scaffolds are highly porous temporary templates for cell adhesion and proliferation, and constitute one of the key ingredients of the tissue regeneration medicine, together with signals for morphogenesis and stem cells .…”

Section: Biological Responsiveness Of Calcium Phosphate/bioactive Glamentioning

confidence: 99%

“…Um et al produced phosphate glass/HA scaffolds and functionalized their surface with bovine serum albumin before the implantation in dogs . It is important to stress the successful clinical application of macroporous Bonelike ® scaffolds, which demonstrated a potential for complete ingrowth of new tissue and permitted effective vascularization throughout the bone defect, as proved by Gutierres et al In this pioneering work, porous Bonelike ® samples were implanted in the tibia of 13 patients during osteotomy surgery with the aim to treat the medial compartment osteoarthritis of the knee.…”

Section: Biological Responsiveness Of Calcium Phosphate/bioactive Glamentioning

confidence: 99%

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Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Bellucci

Sola

Cannillo

2015

J Biomedical Materials Res

117

102

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Calcium phosphates are among the most common biomaterials employed in orthopaedic and dental surgery. The efficacy of such systems as bone substitutes and bioactive coatings on metallic prostheses has been proved by several clinical studies. Among these materials, hydroxyapatite (HA) and tricalcium phosphate (TCP) play a prominent role in medical practice since the '80s. In the last years, numerous attempts to combine HA or TCP with bioactive glasses have been made. There are two main motivations for sintering calcium phosphates with a glassy phase: on the one hand, it is possible to tune the dissolution of the final system and to enhance its biological response through the synergistic combination of two bioactive phases; on the other hand, the glass acts as a sintering aid with the aim to increase the densification of the composite and thus its mechanical strength. In this sense, TCP and HA are penalized by their relatively poor fracture toughness and tensile strength compared to natural bone, which makes it impossible to use them in load-bearing applications. Moreover, the bioactivity index of pure calcium phosphates is typically lower with respect to that of many bioactive glasses. In this review, the state of the art and current applications of composites, based on HA or TCP with bioactive glass as second phase, are presented and discussed. A special emphasis is given to the processing and mechanical behaviour of these systems, together with their biological implications, as a function of the composition of the glass employed as second phase.

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Section: Biological Responsiveness Of Calcium Phosphate/bioactive Glamentioning

confidence: 99%

Section: Biological Responsiveness Of Calcium Phosphate/bioactive Glamentioning

confidence: 99%

Hydroxyapatite and tricalcium phosphate composites with bioactive glass as second phase: State of the art and current applications

Bellucci

Sola

Cannillo

2015

J Biomedical Materials Res

117

102

View full text Add to dashboard Cite

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“…formed by a patented glass-reinforced hydroxyapatite [31], prepared with the incorporation of a P 2 O 5 -based glass in the HA by means of a liquid phase sintering process [32,33], allegedly to increase, simultaneously, the mechanical properties of HA and to introduce ions commonly found in bone tissue [34,35]. According to the producers, Bonelike® is composed of a main crystalline phase of HA and two secondary phases of -and -tricalcium phosphate (TCP) [36].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Comparison of a xenogeneic and an alloplastic material used in dental implants in terms of physico-chemical characteristics and in vivo inflammatory response

Figueiredo

Coimbra

Cabrita

et al. 2013

Materials Science and Engineering: C

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Two commercial bone grafts used in dentistry (Osteobiol Gen-Os®, a xenograft of porcine origin, and Bonelike®, a hydroxyapatite based synthetic material), in the form of granules, were characterized and evaluated in vivo regarding the intensity of the tissue inflammatory response. These biomaterials were characterized in terms of morphology, particle size distribution, porosity and pore size, specific surface are and density. The chemical composition and structure of the materials were accessed by Fourier-Transform Infrared Spectroscopy (FTIR) and X-ray Diffraction (XRD). The graft materials were implanted in the gluteus maximus muscles of Wistar rats and the inflammatory response evaluated through histological analysis, after one week of implantation.The results showed that the two grafts have quite different characteristics in practically all the evaluated properties. While Osteobiol® exhibits a structure and composition similar to the natural bone, Bonelike® is constituted by a main crystalline phase of hydroxyapatite and two secondary phases of -and -tricalcium phosphate. Osteobiol® granules, besides being larger, are irregular, and exhibit sharp-edged tips, while those of Bonelike® are approximately cylindrical, with round contours, and more uniform in size. The in vivo response evaluated from the inflammatory infiltrates revealed that although both implants did not cause severe inflammation, Bonelike® granules elicit a consistently more intense inflammatory reaction than that triggered by the granules of Osteobiol®, particularly in terms of collagen production and formation of fibrous capsule. This reaction was partly explained in terms of the characteristics evaluated for the granules of this material.

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“…The compromise in mech→nic→l properties of the sc→ffold with incre→sing porosity sets →n upper limit on the porosity →nd pore size (Dewid→r & Lim, 2008). Thus, → tr→de-off must be m→int→ined between the biomech→nic→l properties →nd porosity of the m→teri→l needed for www.intechopen.com orthopedic surgery (Ry→n et →l., 2006;Gutierres et →l., 2008). The mech→nic→l properties of → porous structure c→n be determined by v→rious methods including compression, tensile, bending, f→tigue, imp→ct, →nd torsion tests.…”

Section: Mechanical Properties Of Porous Metal Scaffoldsmentioning

confidence: 99%