Bone Health, Vitamin D and Lupus

Cui

Jour. of Adv.in Med. Sci.

et al. 2021

Vitamin D is a hormone precursor with multiple biological effects. It binds to vitamin D receptors on target cells. It is an important participant in the metabolism of calcium and phosphorus in vivo. It is closely related to cell cycle, cell proliferation, differentiation, apoptosis, signal transduction and immune regulation. Its role in the treatment of infection, tumor and even immune diseases has been gradually recognized and studied. Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D, and low levels of vitamin D are associated with disease occurrence, disease activity and complications. In the past ten years, a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus. This paper summarizes its recent research progress.

Section: Relationship Between Vitamin D Deficiency and Sle Complicationsmentioning

confidence: 99%

Study on the Role of Vitamin D in Systemic Lupus Erythematosus

Cui

Jour. of Adv.in Med. Sci.

et al. 2021

“…Como en otras enfermedades autoinmunes, los niveles séricos de vitamina D son bajos, por lo que muchas veces requieren suplementación (15). Intentar elevar el consumo de alimentos que contengan esta vitamina es una buena estrategia con el objetivo es que los pacientes alcancen niveles séricos superiores a 30-40 ng/mL.…”

Section: Nutrición Y Lupus Eritematoso Sistémicounclassified

Nutrición y trastornos del sistema inmune

Plaza

Bermejo

2017

Nutr Hosp

Introduction: Energy and nutrients obtained through food play an important role in the development and preservation of the immune system therefore any nutritional imbalance affects its competence and integrity. Objectives: knowing the nutritional approach on different disorders of the immune system. Methods: A review has been carried out on the most prevalent immunological disorders in developed countries, the nutritional characteristics to which they are associated and their nutritional approach. Results: Nutritional treatment for immune disorders has focused in recent years on the role of PUFA-ω3 and vitamin D. Maintaining body weight, preventing malnutrition and protein catabolism are key strategies for nutritional treatment. This should be adapted to each disease stage because it is a dynamic process. Conclusions: Nutritional treatment for immunological disorders, especially in autoimmune diseases, is not always clear because they present acute and remission states. Anorexia is one of the most characteristic symptoms derived mainly from pharmacological treatment and inflammatory processes. Diet should be dense in nutrients that prevent deterioration. Nutritional treatment of immunological disorders should aim to maintain an optimal state of nutrition during symptomatic periods, prevent their deterioration during acute episodes and improve during stable periods free of symptoms.

The Journal of Immunology

“…Reduced UVR exposure through sun avoidance, protective clothing, and sunscreen is effective and a mainstay in current therapy in the prevention of photosensitivity and its sequela (7)(8)(9). However, reduced UVR exposure can lead to reduced levels of UVR-dependent vitamin D synthesis seen in SLE patients (10), which is thought to contribute to poor bone health and osteoporosis (11). Furthermore, vitamin D is important in immune regulation; reduced vitamin D can potentially exacerbate SLE and its symptoms (12).…”

mentioning

confidence: 99%

Immune Cell–Stromal Circuitry in Lupus Photosensitivity

Sim

Ambler

Sollohub

et al. 2021

Photosensitivity is a sensitivity to UV radiation (UVR) commonly found in systemic lupus erythematosus (SLE) patients who have cutaneous disease. Upon even ambient UVR exposure, patients can develop inflammatory skin lesions that can reduce the quality of life. Additionally, UVR-exposed skin lesions can be associated with systemic disease flares marked by rising autoantibody titers and worsening kidney disease. Why SLE patients are photosensitive and how skin sensitivity leads to systemic disease flares are not well understood, and treatment options are limited. In recent years, the importance of immune cell–stromal interactions in tissue function and maintenance is being increasingly recognized. In this review, we discuss SLE as an anatomic circuit and review recent findings in the pathogenesis of photosensitivity with a focus on immune cell–stromal circuitry in tissue health and disease.