Bone health in healthy Indian population aged 50 years and above

Marwaha, Raman K.; Tandon, Nikhil; Garg, Mahendra Kumar; Kanwar, Ratnesh; Narang, Amit; Sastry, A. V. R.; Saberwal, Akanksha; Bhadra, Kuntal; Mithal, Ambrish

doi:10.1007/s00198-010-1507-8

Cited by 93 publications

(85 citation statements)

References 39 publications

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“…[23] Smaller studies among European men reported either absent[5] or positive association[46] of TC and LDL-c with BMD at femur and spine. These differences can probably be explained by ethnic differences in BMD[31] and lipid levels. [27] It has been proposed that oxidized LDL increase Receptor activator of nuclear factor kappa-B ligand expression on osteoblast and increase interaction with osteoclast which affect bone remodeling and may cause decrease in BMD.…”

Section: Discussionmentioning

confidence: 99%

Relationship of lipid parameters with bone mineral density in Indian population

Garg

Marwaha

Tandon

et al. 2014

Indian J Endocr Metab

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Introduction:Cardiovascular disease and osteoporosis share common risk factors including dyslipidemia. There are conflicting reports of differential relation of various lipid parameters on bone mineral density (BMD). Hence, we studied the correlation between lipid parameters and BMD in healthy adult.Materials and Methods:A total of 2347 participants (male 39.4%; female 60.6%) included in this cross-sectional study were divided according to sex and age. Fasting blood samples were drawn for biochemical parameters. BMD at lumbar spine, femur, and forearm were measured by dual energy X-ray absorptiometry (DXA).Results:In males, BMD at femur and lumbar spine decreased significantly with increasing quartiles of total cholesterol (TC) (P < 0.0001, and 0.004) and low-density lipoprotein cholesterol (LDL-c) (P = 0.001, and 0.01). In premenopausal women, BMD at femoral neck (P = 0.001) and lumbar spine (P = 0.029) showed declining trend with LDL-c (P = 0.007). In postmenopausal women, only BMD at total femur decreased significantly with TC (P = 0.024) and LDL-c (P = 0.036). All above findings were confirmed in correlation studies. In multiple regression analysis after adjusting for age, body mass index, ionized calcium, alkaline phosphatase, 25 hydroxy vitamin D, and parathyroid hormone levels correlation of BMD with TC and LDL-c persisted. TC, LDL-c was higher in subjects with low bone density compared those with normal bone density in both sexes.Conclusions:TC and LDL-c had weak but significant negative correlation with BMD at femur and lumbar spine.

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Section: Discussionmentioning

confidence: 99%

Relationship of lipid parameters with bone mineral density in Indian population

Garg

Marwaha

Tandon

et al. 2014

Indian J Endocr Metab

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“…In the study by Marwaha et al osteoporosis was reported to be 26.4% in male subjects and osteopenia 54.3% in male subjects. 17 Shetty et al reported slightly lesser values of osteoporosis (20%) and slightly higher values of osteopenia (58%) in south Indian men aged above 50 years. 18 Whereas in our study out of 250 male participants, 5 (2%) and 51 (20.4%) participants were found to satisfy the criteria of ≥20% major osteoporotic risk and ≥3% hip fracture risk respectively.…”

Section: Discussionmentioning

confidence: 92%

Screening for absolute fracture risk using FRAX tool in men and women within 40-90 years in urban population of Puducherry, India

et al. 2017

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INTRODUCTIONAdvancement in health care sector has resulted in increase of the aging population. This has leaded to increase in the proportion of patients with osteopenia and osteoporosis in both developed and developing countries like India. Osteoporosis is presently considered as one of the major non-communicable world health problem. Throughout the world, osteoporosis is said to cause more than 8.9 million fractures yearly, resulting in an osteoporotic fracture every 3 seconds.1,2 It predominantly affects post-menopausal women, elderly men and women. It is calculated that the residual lifetime risk of experiencing an osteoporotic fracture in men over the age ABSTRACT Background: Osteoporosis is presently considered as one of the major non-communicable world health hazards. It predominantly affects post-menopausal women, elderly men and women. The aim of the study was to assess fracture risk among men and women within 40-90 years in urban population of Puducherry, India and detect the most prevalent risk factors for fractures. Methods: This is a cross-sectional study done over a period of two months (July -August 2015) involving a sample size of 500 participants, 250 in each gender. Using the FRAX (Fracture Risk Assessment) tool the major osteoporotic fracture risk percentage (MOFR) and hip fracture risk (HFR) were obtained without femoral neck bone mineral density. Chi-square test was applied to test association and p<0.05 considered statistically significant. Results: The mean age of males (57.2±12.7 years) was higher than females (52.5±2.6 years). Out of 500 participants, 18 and 95 participants were found to satisfy the criteria of ≥20% MOFR and ≥3% HFR respectively. The average MOFR was 4.5±6.7 and 4.0±4.6 for women and men respectively. The mean HFR was 1.8±4.0 and 1.8±3.3 for women and men respectively. The requirement of treatment did not differ significantly between gender (44 females versus 51 males). Eight male participants and 9 female participants were advised for further evaluation with a DEXA scan. Conclusions:The FRAX tool provides an aid to enhance patient assessment by the integration of clinical risk factors especially as an osteoporosis screening tool with/without the combination of bone mineral density. It is an effective tool, particularly in developing countries like India, where most of the patients cannot afford expensive investigations like DEXA. People with high risk can be subjected to further evaluation and management, thereby reducing the health resources.

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“…The increase in prevalence of LI symptoms in the older (!50) age group may be due to low lactase activity and metabolism of lactose by colonic bacteria which has been shown to play a role in LI development (He et al, 2006). A recent study revealed that osteoporosis was highly prevalent in healthy Indians aged 50 years and above (Marwaha et al, 2011). This suggests that there may be an association between LI and osteoporosis.…”

Section: Discussionmentioning

confidence: 96%