Bone healing at implants with a fluoride‐modified surface: an experimental study in dogs

Berglundh, Tord; Abrahamsson, Ingemar; Albouy, Jean‐Pierre; Lindhe, Jan

doi:10.1111/j.1600-0501.2006.01309.x

Cited by 194 publications

(161 citation statements)

References 17 publications

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“…Titanium has long been considered a stable material for chemical agents owing to its passive state film, but it is possible to change the oxidized titanium surface through exposure to high temperature and strong acid or alkali solutions 14,15) . Recent studies that showed the use of hydrofluoric acid at low concentrations to modify titanium dioxide surfaces revealed increased bone-to-implant contact, enhanced removal-torque, pull-out forces, and differentiation of mesenchymal stem cells [16][17][18] . Acidic fluoride solutions have also been observed to corrode commercially pure titanium and its alloys [19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

et al. 2014

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The purpose of the present study was to clarify the potentiality of acidic fluoride solution in treating peri-implantitis. We examined bactericidal activity of fluoride solution against periodontal pathogens; and evaluated the effects of fluoride on titanium, and the effects on cell proliferation and differentiation of rat bone marrow cells on the fluoride-treated titanium. Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were used to determine minimal inhibitory concentration (MIC) and shorttime exposure. The cells were seeded on the titanium surface with or without fluoride treatment. Then, cellular proliferation, differentiation and mineral deposition were analyzed. The MIC values for A. actinomycetemcomitans and P. gingivalis were 225 and 900 ppm F − , respectively. In short-time exposure test, both bacterial strains exhibited a significant decrease in a concentrationdependent manner. Cell proliferation and mineral deposition were significantly increased on the fluoride-treated surface. Within the limitation of this study, acidic sodium fluoride solution has the potentiality in treating peri-implantitis.

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Section: Introductionmentioning

confidence: 99%

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

et al. 2014

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“…Oxidation in H 2 O 2 /0.1 M HCl at 80 ∘ C resulted in a good adhesion of arginine-glycine-aspartic acid peptides as well as the calcified matrix formation of rat bone marrow stromal cells [72]. Several studies demonstrated the ability of HF acid, when treated on TiO 2 grit-blasted Ti implants, to enhance the osteoinductive function, differentiation from mesenchymal stem cells into osteoblasts, and early osseointegration [30,35,73,74] …”

Section: Acid Oxidation or Peroxidationmentioning

confidence: 99%

Nanofeatured Titanium Surfaces for Dental Implantology: Biological Effects, Biocompatibility, and Safety

Baena

Rizzo

Manzo

et al. 2017

Journal of Nanomaterials

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Nanotechnology enables the control and modification of the chemical and topographical characteristics of materials of size less than 100 nm, down to 10 nm. The goal of this review is to discuss the role of titanium substrates as nanoscale surface modification tools for improving various aspects of implantology, including osseointegration and antibacterial properties. Techniques that can impart nanoscale topographical features to endosseous implants are described. Since the advent of nanotechnology, cellular specific functions, such as adhesion, proliferation, and differentiation, have been better understood. By applying these technologies, it is possible to direct cellular responses and improve osseointegration. Conversely, modulating surface features by nanotechnology could have the effect of decreased bacterial colonization.

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“…The carbon compounds adhering to the titanium surface at the time of placement of the implant are an important factor in determining early adhesion of osteoblast cells to the titanium surface 16) . However, it is not possible to control the accumulation of organic matter during production of titanium implants 10,32) . Other reported methods of managing carbon compound adhesion are ultraviolet treatment 33) , storage in saline solution 34) , and gamma-ray irradiation 35) .…”

Section: Push-in Testmentioning

confidence: 99%

Effect on Osteogenesis of Cleaning Titanium Implants with Ozonated Water

Yoshida

Ando

Sugita

et al. 2016

J. Hard Tissue Biology.

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Carbon compounds accumulate over time on titanium surfaces. This is reported to reduce osseointegration of titanium implants in bone. Ozonated water was found to remove carbon compounds and to have a sufficient cleaning effect. The effects of the ozonated water on the titanium surface were evaluated by cell culture and mechanical tests. In vitro study, titanium disks (diameter 20 mm, thickness 1 mm, Grade 2) were treated with sulfuric acid. Disks in the control group were surface cleaned with distilled water, and disks in the O 3 group were surface cleaned for 10 min with ozonated water. The experimental animals were male Sprague-Dawley (SD) rats. We tested for cell proliferation activity, alkaline phosphatase (ALP) activity, calcification and measured calcium concentrations. In vivo study, titanium implants (diameter 1 mm, length 2 mm, Grade 2) were treated with sulfuric acid. Control group samples were washed for 10 min with distilled water immediately before implantation. O 3 group samples were washed for 10 min with ozonated water. We performed push-in testing using a mechanical testing machine. The femurs were removed at 2 and 4 weeks after implantation. Cell proliferation activity was higher in the O 3 group than in the control group at 24 h after cell seeding. Similarly, ALP activity was higher in the O 3 group than in the control group, indicating higher cell differentiation potential. Cell calcification was higher in the O 3 group than in the control group at all measurement times. Maximum compressive stress was significantly higher in the O 3 group compared with the control group at 2 weeks after implantation (p < 0.05). At 4 weeks after implantation, no difference was found between the groups. Osseointegration time was decreased by cleaning titanium implants with ozonated water.

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Bone healing at implants with a fluoride‐modified surface: an experimental study in dogs

Abstract: It is suggested that the fluoride-modified implant surface promotes osseointegration in the early phase of healing following implant installation.

Cited by 194 publications

References 17 publications

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

Effects of acidic sodium fluoride-treated, commercially pure titanium on periodontal pathogens and rat bone marrow cells

Nanofeatured Titanium Surfaces for Dental Implantology: Biological Effects, Biocompatibility, and Safety

Effect on Osteogenesis of Cleaning Titanium Implants with Ozonated Water

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