Bone Grafts in Periodontal Therapy

Sukumar, Sujith; Drízhal, I

doi:10.14712/18059694.2017.25

Cited by 46 publications

(52 citation statements)

References 31 publications

(29 reference statements)

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“…The disease causes inflammation and destruction of periodontal tissues, eventually leading to tooth mobility and tooth loss. Attempts have been made to repair and regenerate these destroyed tissues, including the use of specific bioactive substances or surgical bone grafts (20). For periodontal regenerative therapy, attachment gain is the most important event, and this requires migration of periodontal cells to cover the formerly disease-affected cementum or dentin.…”

Section: Introductionmentioning

confidence: 99%

Role of HMGB1 in proliferation and migration of human gingival and periodontal ligament fibroblasts

2013

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High mobility group box 1 (HMGB1)was originally defined as a nuclear protein. However, later studies showed that HMGB1 was released from damaged cells into the extracellular milieu and functioned as a danger signaling molecule. HMGB1 has also been shown to exert proliferative and chemoattractant effects on many cell types. In this study, we investigated the in vitro effect of human recombinant HMGB1 on the proliferation and migration of human gingival fibroblasts (HGF) and human periodontal ligament fibroblasts (HPDLF). For the proliferation assay, HGF and HPDLF were cultured in the presence of 5, 10, and 50 ng/mL HMGB1. After a period of 6 days, cell proliferation was determined by MTT assay.

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Section: Introductionmentioning

confidence: 99%

Role of HMGB1 in proliferation and migration of human gingival and periodontal ligament fibroblasts

2013

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“…1 It is thus the most predictable osteogenic organic graft for osseous tissue regeneration and is thus considered as 'Gold Standard' amongst bone grafts. Within the limits of the study, it is suggested that autogenous bone grafts are most predictable for periodontal regeneration and the symphysis menti is an excellent source for obtaining this corticocancellous graft.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…1 The key to tissue regeneration is stimulation of a cascade of healing events which in a coordinated manner result in completion of integrated tissue formation. 1 Periodontal regeneration has been achieved most successfully using either osseous grafting or guided-tissue regeneration (GTR). 2 The conventional approach of surgical debridement and respective procedures for correction of periodontal pockets resulted in healing by formation of the long junctional epithelium.…”

Section: Introductionmentioning

confidence: 99%

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Are We Overlooking Our ‘Gold Mine’? Use of Symphysial Autograft for Treatment of Periodontal Osseous Defect

Bhardwaj¹,

Grover²,

Luthra³

2012

International Journal of Experimental Dental Science

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This case report presents a technique for utilizing autogenous corticocancellous graft from the mandibular symphysial area to fill a three-walled infrabony defect in a patient diagnosed with generalized aggressive periodontitis. After debridement, a 9 mm defect was present distal to the mandibular first molar. Autogenous bone graft harvested from the mandibular symphysial region was placed in the defect. There was a significant fill at the site 9 months postoperative and a reduction in probing depth was recorded at 4 mm.

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“…A standard procedure in the treatment of periodontal pockets is an MWRO (modified flap operation), but it shows little success in eliminating infrabony periodontal defects; thus, to enhance the regeneration of periodontal tissues, we have assessed various bone substituents (3,4). A novel concept for the regeneration of periodontal tissues is based on the application of biomaterials that enable regeneration of the paradentium with varied efficiency (5).…”

Section: Introductionmentioning

confidence: 99%

Evaluaton of the Use of Bone Implants as a Therapy for Deep Defects in the Parodoncium

Stevanović

Ciric

2014

Serbian Journal of Experimental and Clinical Research

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Reconstruction of infrabony defects created by the chronic inflammatory processes of parodontopathy represents a major clinical problem in paradontology. The objective of this research was to compare and evaluate the efficiency of two bone substituents at reversing the deep infrabony defects in the paradentium after the application of a new “Biohapel” material consisting of biphasic calcium phosphate/poly DL-lactide-co-glycolide. This study included 12 patients of both genders with an average age of 49.7 years who were suffering from clinically manifested parodontopathy. The main criteria for selecting patients were the presence of six similar infrabony periodontal defects that were at least 4 mm deep and in the lower side of the teeth on both sides of the jaw. After applying a basic causal parodontopathy treatment, defects were divided into two groups, including an experimental group (n=72) in which defects were reconstructed using the “Biohapel” bone substituent (on one side of the lower jaw) and a control group (n=72) in which infrabony defects were reconstructed using β tricalcium phosphate (βTCP) (CerasorbR), a preparation very commonly applied in regenerative parodontopathy treatment (on the other side of the lower jaw). Markers to assess treatment efficacy were determined before surgery and 6 months after surgery by measuring the depth of periodontal pocket and the level of the junctional epithelium. We observed statistically significant differences in the periodontal regeneration markers between the experimental and control groups (p<0.05). Application of “Biohapel” during the surgical treatment of infrabony defects in the paradentium significantly improves the bone regeneration of the paradentium when compared with the standard application of β-tricalcium phosphate .

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Bone Grafts in Periodontal Therapy

Abstract: This article is limited to a review of bone replacement graft materials used in periodontal therapy. The source, mode of bone regeneration and the respective advantages and disadvantages of autogenous, allogenic, xenogenic and alloplastic materials are discussed.

Cited by 46 publications

References 31 publications

Role of HMGB1 in proliferation and migration of human gingival and periodontal ligament fibroblasts

Role of HMGB1 in proliferation and migration of human gingival and periodontal ligament fibroblasts

Are We Overlooking Our ‘Gold Mine’? Use of Symphysial Autograft for Treatment of Periodontal Osseous Defect

Evaluaton of the Use of Bone Implants as a Therapy for Deep Defects in the Parodoncium

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