Bone formation and implant degradation of coralline porous ceramics placed in bone and ectopic sites

Pollick, Sharon; Shors, Edwin C.; Holmes, Ralph E.; Kraut, Richard A.

doi:10.1016/0278-2391(95)90281-3

Cited by 76 publications

(52 citation statements)

References 24 publications

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“…In the family of metals, porous titanium (Ti) has shown osteoinductivity, alone Takemoto et al, 2005), coated with a thin layer of calcium phosphate (Barrere et al, 2003) or in a construct with a calcium phosphate ceramic . In contrast to the limited number of reports on osteoinduction by polymers and metals, ceramicsparticularly calcium phosphate based ones -have shown osteoinductive potential in a variety of studies: HA (Ripamonti, 1991;Vargervik, 1992;Yamasaki and Sakai, 1992;van Eeden and Ripamonti, 1994;Pollick et al, 1995;Magan and Ripamonti, 1996;Ripamonti, 1996;Yuan et al, 1999;Ripamonti et al, 2009), β-tricalcium phosphate (β-TCP) (Yuan et al, 2001a;Yuan et al, 2001e), biphasic calcium phosphate (BCP), that designates the mixture of HA and TCP (Yang et al, 1996;Gosain et al, 2002), dicalcium phosphate anhydrous (DCPA), dicalcium phosphate dihydrate (DCPD) (Habibovic et al, 2008a), carbonated apatite (Habibovic et al, 2008b), calcium pyrophosphates (CPP) (Vargervik, 1992;Toth et al, 1993) and HA/calcium carbonate (CC) mixtures (Pollick et al, 1995;Ripamonti et al, 2010). A case of osteoinductive glass ceramic has also been reported (Yuan et al, 2001b).…”

Section: Osteinductive Biomaterialsmentioning

confidence: 99%

“…In the past decade, a large number of publications illustrated osteoinduction by diverse calcium phosphate biomaterials in the form of sintered ceramics (Yamasaki, 1990;Ripamonti, 1991;Zhang, 1991;Vargervik, 1992;Yamasaki and Sakai, 1992;Klein et al, 1994;Pollick et al, 1995;Ripamonti, 1996), cements Gosain et al, 2002;Habibovic et al, 2008a), coatings (Barrere et al, 2003;Habibovic et al, 2004), as well as coral-derived ceramics (Ripamonti, 1991;Pollick et al, 1995;Magan and Ripamonti, 1996;Ripamonti, 1996;Ripamonti et al, 2009;Ripamonti et al, 2010), in various animal models. Also composites consisting of a polymer and HA have shown to be able to induce bone formation heterotopically (Hasegawa et al, 2007;Barbieri et al, 2010).…”

Section: Defi Nitions and Historical Backgroundmentioning

confidence: 99%

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Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

445

365

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In the past thirty years, a number of biomaterials have shown the ability to induce bone formation when implanted at heterotopic sites, an ability known as osteoinduction. Such biomaterials -osteoinductive biomaterials -hold great potential for the development of new therapies in bone regeneration. Although a variety of well characterised osteoinductive biomaterials have so far been reported in the literature, scientists still lack fundamental understanding of the biological mechanism underlying the phenomenon by which they induce bone formation. This is further complicated by the observations that larger animal models are required for research, since limited, if any, bone induction by biomaterials is observed in smaller animals, including particularly rodents. Besides interspecies variation, variations among individuals of the same species have been observed. Furthermore, comparing different studies and drawing general conclusions is challenging, as these usually differ not only in the physico-chemical and structural properties of the biomaterials, but also in animal model, implantation site and duration of the study. Despite these limitations, the knowledge of material properties relevant for osteoinduction to occur has tremendously increased in the past decades. Here we review the properties of osteoinductive biomaterials, in the light of the model and the conditions under which they were tested. Furthermore, we give an insight into the biological processes governing osteoinduction by biomaterials and our view on the future perspectives in this research fi eld.

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Section: Osteinductive Biomaterialsmentioning

confidence: 99%

Section: Defi Nitions and Historical Backgroundmentioning

confidence: 99%

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Barradas

Yuan²,

Blitterswijk³

et al. 2011

eCM

445

365

View full text Add to dashboard Cite

show abstract

“…A HAP é esterilizável e relativamente não absorvível (Pollick et al, 1995;Ono et al, 2000). É vantajosa por causa de sua composição uniforme, alta biocompatibilidade, segurança (não é tóxica, nem alergênica ou carcinogênica) e pelo fato de sua microestrutura (tamanho dos poros) ser completamente controlável (Ono et al, 2000).…”

Section: Introductionunclassified

Biocompatibilidade e comportamento de compósitos de hidroxiapatita em falha óssea na ulna de coelhos

Vital¹,

Borges²,

Fonseca³

et al. 2006

Arq. Bras. Med. Vet. Zootec.

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RESUMOAvaliaram-se os compósitos de hidroxiapatita sintética e carbono (HAC) e hidroxiapatita sintética, carbono e fosfato biácido de sódio (HACF), ambos na forma sólida, como substituto ósseo em 36 coelhos adultos. Após protocolos anestésico e cirúrgico habituais, retirou-se um fragmento de aproximadamente 2cm de comprimento no terço médio da ulna esquerda. Os animais do grupo 1 receberam, em cada falha provocada, blocos de HAC e HACF, e os do grupo 2 somente HAC. Os do grupo 3 não receberam tratamento. Os animais foram submetidos a avaliações clínicas e radiológicas nos dias 8, 15, 30, 60, 120 e 180 de pós-operatório. Nas mesmas datas, dois animais de cada grupo foram sacrificados e deles colheuse material para histologia. Observou-se evolução normal da regeneração óssea em todos os animais, sendo mais precoce nos dos grupos que receberam os compósitos. O uso de HAC e HACF na ulna de coelho mostrou-se um método eficiente, não apresentando sinais de infecção e nem evidência de rejeição.Palavras -chave: coelho, biomaterial, hidroxiapatita, substituto ósseo ABSTRACT Composites of synthetic hydroxyapatite and carbon (HAC) and synthetic hydroxyapatite, carbon and sodium biacid phosphate (HACF), both of them in solid form

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“…Scanning electron microscopy (SEM) is another well-known technique for quantifying CaP materials that have been implanted in bone. 4 Although image analysis of grayscale SEM images has been validated, 5 scanning electron microscopes are not widely available, and sampling for SEM is often limited. Furthermore, once a section has been stained for light microscopy, the section cannot be easily analyzed by SEM.…”

Section: Introductionmentioning

confidence: 99%

Analytical technique for quantification of selected resorbable calcium phosphate bone void fillers with the use of polarized‐light microscopy

Clineff¹,

Erbe²,

Bauer

et al. 2004

J Biomed Mater Res

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Synthetic calcium phosphate bone void fillers promote varying rates of bone formation and material resorption depending on chemistry, porosity, pore structure, and implant site. The objective of this study was to quantify the resorption of a novel ultraporous ␤-tricalcium phosphate cancellous bone void filler with simultaneous quantification of bone formation in a canine humerus model. Potential measurement error involved in conventional histomorphometry using Von Kossa stains inspired the development of a new technique. This technique utilizes bright-field and polarized-light microscopy in conjunction with image analysis software, allowing more accurate histomorphometry. This technique was validated with two separate controlled experiments. Scanning electron microscopy further supported the results. The findings suggest that the use of polarized-light microscopy combined with image analysis software can be an effective tool in simultaneously quantifying calcium phosphate resorption and bone formation.

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Bone formation and implant degradation of coralline porous ceramics placed in bone and ectopic sites

Cited by 76 publications

References 24 publications

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Osteoinductive biomaterials: current knowledge of properties, experimental models and biological mechanisms

Biocompatibilidade e comportamento de compósitos de hidroxiapatita em falha óssea na ulna de coelhos

Analytical technique for quantification of selected resorbable calcium phosphate bone void fillers with the use of polarized‐light microscopy

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