Bone Density Measurement Using Computed Tomography

Çelenk, Çetin; Çelenk, Peruze

doi:10.5772/22884

Cited by 21 publications

(12 citation statements)

References 31 publications

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“…Thus, the skeletal trauma pathologies that result from age (e.g., vertebral compression fractures ), from injury (e.g., previous fall events), and/or from medical intervention (e.g., cardiopulmonary resuscitation ) were accounted for in order to differentiate existing pathology from the BFT that actually resulted from the fall event of interest, as best as possible. The HU density of a 3–4 cm 3 region of the third lumbar vertebral body was recorded to provide a correlate of spinal photon attenuation to chronological age (i.e., a rough volumetric bone mineral density). This correlation, a Spearman Rank correlation, was performed to ensure it was appropriate to use chronological age as a variable in the analysis, and to highlight widespread bone‐based pathologies that would lead to a diagnosis of generalized skeletal disease.…”

Section: Methodsmentioning

confidence: 99%

Skeletal Trauma Resulting From Fatal Low (≤3 m) Free Falls: An Analysis of Fracture Patterns and Morphologies

Rowbotham

Blau

Hislop-Jambrich³

et al. 2017

Journal of Forensic Sciences

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The skeletal trauma resulting from fatal low (≤3 m) free falls is poorly researched and understood by forensic practitioners. The aim of this study was to identify the types of skeletal trauma resulting from low falls through investigating fracture patterns and morphologies. Skeletal trauma was analyzed using full-body postmortem computed tomography scans of 145 individuals who died from a low free fall. Trauma was then contextualized to the variables that influence how a person falls using multiple logistic regression. Results showed fracture patterning primarily involved the axial skeleton and that there were a number of patterns significantly associated with the height fallen, pre-existing health conditions, and age. Analysis of fracture morphologies showed 108 possible fracture types, six of which were significantly associated with the height fallen. Understanding the skeletal trauma characteristic of low free falls will further inform anthropological interpretations of trauma in cases where a fall may be considered the possible mechanism.

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Section: Methodsmentioning

confidence: 99%

Skeletal Trauma Resulting From Fatal Low (≤3 m) Free Falls: An Analysis of Fracture Patterns and Morphologies

Rowbotham

Blau

Hislop-Jambrich³

et al. 2017

Journal of Forensic Sciences

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“…Osteoporosis being the one of the most common bone ailment, it has been affecting our societies from a very long time and is mainly described as the disruption of the equilibrium between bone formation and resorption (8) . Subsequently this loss of bony constituent creates changes in bone microarchitecture which markedly favours the incidence of fractures, all of which makes it closely related with high morbidity and mortality rates (9) . Reduction in skeletal muscle mass can be linked to decline BMD (10) .…”

Section: Discussionmentioning

confidence: 99%

Estimating the Proportion of Bone Mineral Density Loss in Patients with Normal Kidney Function among South Indian Population

Aranha¹,

Kotian²,

John³

2021

IJPHRD

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Background: Bone Mineral density (BMD) is considered as one of the golden tool to measure the bone quality in which two measurements namely T-Score and Z -score are used to report the BMD test results. Whenever there is deterioration of BMD it is associated with low skeletal mass. Creatinine is a chemical waste molecule that is generated from this muscle metabolism. Creatinine is a good marker for muscle mass. However, limited studies have been done which tell us the association between BMD loss and serum creatinine (SCr) levels.Methodology: 200 participants who were referred for CECT abdomen and pelvis were scanned using 128 slice Philips Brilliance CT. Using BMD software, four different vertebral bodies from L1-L4 were taken and ROI was placed at the central portion of the trabecular bone, two reference ROI's, one in retro spinal muscle and one in fat tissue were also placed. To measure CT attenuation value, a ROI graphic tool was drawn at the trabecular bone. Average HU of BMD, T score and Z score values were taken from L1-L4. Statistical Analysis:The data was analysed using SSPS version 16.0. For assessment of normal BMD values, the results of measurements were averaged for age, creatinine level, T score and Z score and descriptive statistics was calculated. Spearman's correlation coefficient was used to estimate the correlation between serum creatinine with T score and Z score.Results: T Score and SCr correlated negatively at -0.25. The correlation between Z Score and SCr was also negatively correlated at -0.187. Conclusion:It was evident from the study findings, that there is a non-association between SCr and T Score levels which showed that BMD of a person was not associated with normal kidney function. Thus, SCr levels cannot be used as a biomarker for osteoporosis or osteopenia.

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Section: Discussionmentioning

confidence: 99%

Estimating the proportion of bone mineral density loss in patients with normal kidney function among South Indian population

Aranha

Kotian²,

John

2020

Preprint

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Background: Bone Mineral density (BMD) is considered as one of the golden tool to measure the bone quality in which two measurements namely T- Score and Z –score are used to report the BMD test results. Whenever there is deterioration of BMD it is associated with low skeletal mass. Creatinine is a chemical waste molecule that is generated from this muscle metabolism. Creatinine is a good marker for muscle mass. However, limited studies have been done which tell us the association between BMD loss and serum creatinine (SCr) levels.Methodology: 200 participants who were referred for CECT abdomen and pelvis were scanned using 128 slice Philips Brilliance CT. Using BMD software, four different vertebral bodies from L1-L4 were taken and ROI was placed at the central portion of the trabecular bone, two reference ROI’s, one in retro spinal muscle and one in fat tissue were also placed. To measure CT attenuation value, a ROI graphic tool was drawn at the trabecular bone. Average HU of BMD, T score and Z score values were taken from L1-L4.Statistical Analysis: The data was analysed using SSPS version 16.0. For assessment of normal BMD values, the results of measurements were averaged for age, creatinine level, T score and Z score and descriptive statistics was calculated. Spearman’s correlation coefficient was used to estimate the correlation between serum creatinine with T score and Z score.Results: T Score and SCr correlated negatively at -0.25. The correlation between Z Score and SCr was also negatively correlated at -0.187.Conclusion: It was evident from the study findings, that there is a non-association between SCr and T Score levels which showed that BMD of a person was not associated with normal kidney function. Thus, SCr levels cannot be used as a biomarker for osteoporosis or osteopenia.

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Bone Density Measurement Using Computed Tomography

Cited by 21 publications

References 31 publications

Skeletal Trauma Resulting From Fatal Low (≤3 m) Free Falls: An Analysis of Fracture Patterns and Morphologies

Skeletal Trauma Resulting From Fatal Low (≤3 m) Free Falls: An Analysis of Fracture Patterns and Morphologies

Estimating the Proportion of Bone Mineral Density Loss in Patients with Normal Kidney Function among South Indian Population

Estimating the proportion of bone mineral density loss in patients with normal kidney function among South Indian population

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