Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006

Kindler, Joseph M.; Zhan, Dongling; Sattler, Elisabeth Lilian Pia; Ishikawa, Yuta; Chen, X; Gallo, Sina

doi:10.1007/s00198-021-06148-2

Cited by 2 publications

(2 citation statements)

References 30 publications

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“…A disconnect in the muscle–bone connection, increased abdominal visceral fat, longer time since T2D diagnosis, and poor diet quality were associated with lower BMD Z -score in this study sample [37 ▪ ,38 ▪ ]. In a separate study [57 ▪ ], similar age-related differences in BMD Z -scores during later adolescence were evident in youth with impaired glucose regulation when adjusting for BMI. These studies suggest that diabetes-related bone deficits might threaten peak bone mass attainment and occur before onset of T2D.…”

Section: Insulin Resistance and Bone Healthsupporting

confidence: 51%

Insulin resistance and skeletal health

Lei

Kindler

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of reviewBone fragility is a complication of type 2 diabetes (T2D), and insulin resistance is suspected to contribute to diabetes-related bone deficits. This article provides an overview of emerging clinical research involving insulin resistance and bone health by summarizing recent publications, identifying existing knowledge gaps, and suggesting 'next steps' for this evolving field of research. Recent findingsClinical studies in children and adults report greater bone density in people with increased insulin resistance, but these associations are often attenuated when adjusting for body size. Advancements in bone imaging methods allow for assessment of nuanced characteristics of bone quality and strength that extend beyond standard bone mineral density assessment methods. For example, several recent studies focusing on lumbar spine trabecular bone score, a relatively new measure of trabecular bone quality from dual-energy X-ray absorptiometry, have reported generally consistent inverse associations with insulin resistance. Longitudinal studies using advanced imaging methods capable of evaluating trabecular bone microstructure and strength, such as high-resolution peripheral quantitative computed tomography, are lacking. Studies in younger individuals are sparse, but emerging data suggest that peak bone mass attainment might be threatened by diabetes progression, and increased visceral fat, suppressed muscle-bone unit, advanced glycation endproducts, sedentary lifestyle, and poor diet quality might contribute to diabetes effects on bone. Prospective studies during the transition from adolescence to young adulthood are required.

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Section: Insulin Resistance and Bone Healthsupporting

confidence: 51%

Insulin resistance and skeletal health

Lei

Kindler

2022

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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“…However, these results were not in line with the findings in youth with diabetes and prediabetes. An NHANES study of 2005–2006 ( 26 ) enrolled youth aged 12-20 years with prediabetes and NGR and demonstrated that children with prediabetes have higher BMD, while adolescents and young adults with prediabetes tended to have lower BMD, suggesting a different biological effect of diabetes progression on bone health during the growing period. A Korean study ( 27 ) found that obese children and adolescents with T2D had significantly lower BMD Z-scores at the femoral neck compared with age-, sex-, and BMI-matched controls.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

2022

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BackgroundAccumulating evidence has shown that diabetes has an impact on bone metabolism with conflicting results. Furthermore, little is known about the relationship of prediabetes with bone mineral density (BMD). Therefore, we explored the association between BMD and glucometabolic status in adults in the US.MethodsIn this cross-sectional study, we extracted and analyzed data from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. A total of 14610 subjects aged 40 ≥ years diagnosed with diabetes, prediabetes, or normal glucose regulation (NGR) and had available data on BMD were eligible.ResultsThe prevalence of prediabetes and diabetes in US adults aged 40 ≥ years were 39.2% and 26.4%, respectively. After multivariable adjustment, we found an increasing trend of BMD at the total hip, femoral neck, and lumbar spine with glucometabolic conditions from NGR and prediabetes to diabetes in adults aged ≥ 40 years in the US. This trend was more prominent in women than that in men. Fasting plasma glucose (FPG) and HbA1c levels were also positively correlated with BMD.ConclusionsGlucometabolic conditions were significantly associated with BMD values in US adults.

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Bone density in youth with prediabetes: results from the National Health and Nutrition Examination Survey, 2005–2006

Cited by 2 publications

References 30 publications

Insulin resistance and skeletal health

Insulin resistance and skeletal health

Comparison of Bone Mineral Density in US Adults With Diabetes, Prediabetes and Normoglycemia From 2005 to 2018

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