Bone Densitometry: Applications and Limitations

Syed, Zeba A.; Khan, Aliya

doi:10.1016/s1701-2163(16)31095-7

Cited by 75 publications

(53 citation statements)

References 30 publications

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“…Ved diagnostisering av beintap anses Dual emission X-ray absorptiometry (DEXA) som gullstandardmetoden (8). I dag behandles beinskjørhet hos ryggmargsskadede med funksjonell elektrisk stimulering (FES) (fig 1), ståtrening og medikamentell behandling (kalsium, fosfat, vitamin D og bisfosfanater).…”

Section: Forstyrrelser I Beinmetabolismenunclassified

Komplikasjoner etter kronisk ryggmargsskade

Kostovski¹,

Iversen²,

Hjeltnes³

2010

Tidsskriftet

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Section: Forstyrrelser I Beinmetabolismenunclassified

Komplikasjoner etter kronisk ryggmargsskade

Kostovski¹,

Iversen²,

Hjeltnes³

2010

Tidsskriftet

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“…6 But the commonest used modality of measuring bone density still remains to be calcaneal QUS. It has gained the importance in the situation where tools like DEXA are not available.…”

Section: Introductionmentioning

confidence: 99%

Screening of osteoporosis using calcaneal quantitative ultrasound in a rural population of Jammu, Jammu and Kashmir, India

Gupta¹,

Mahajan²,

Dewan

et al. 2017

Int J Community Med Public Health

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Background: Osteoporosis is a major public health problem, associated with substantial morbidity and socio-economic burden. The objective of the present study was to screen the general population for osteoporosis in a rural area of Jammu region. Methods: 3 screening camps were conducted at 6 monthly intervals between the time period 2015-2016, at the Accidental Hospital, Chowki Choura, which is a rural area of district Jammu, J&K. A total of 270 subjects in the age group 20 to 80 years were subjected to screening through BMD measurements using calcaneal QUS and they were analyzed on the basis of T-scores. Results: Out of 270 subjects, 120 were males and 150 were females. Among 120 males, 68 were in the age group of 20 - 49 years, and 52 were above 50 years. In the age group 20-49 years, 26 males (38.2%) had osteopenia, and 4 (5.9%) had osteoporosis. In males above 50 years of age, 35 (67.3%) had osteopenia and 6 (11.5%) had osteoporosis. Out of 150 females, 94 were in the age groups 20-49 years, and 56 were above 50 years of age. In the age group 20-49 years, 51 females (54.3%) had osteopenia and 12 (12.8%) had osteoporosis. In females above 50 years of age, 32 (57.1%) had osteopenia and 15 (26.8%) had osteoporosis. Conclusions: The overall prevalence of osteoporosis among screened population was 13.7%. It increased with age in both males and females; however the prevalence of osteoporosis was more among females as compared to males (18% vs. 8.3% respectively).

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“…Increased bone weight is considered a good indicator of anti-osteoporotic activities (77,78), despite the fact that changes in bone weight are not an important marker for evaluating anti-osteoporotic agents, with the exception of ash bone weight (79). For an osteoporosis-related OVX model, serum bALP content and osteocalcin levels are typically accepted as bone turnover markers (80)(81)(82), and BMD is used as a major determinant of osteoporosis (83)(84)(85). As microscopic observation of bone can provide good evidence regarding bone morphology (35,37,38,86), trabecular and cortical bone is significantly changed in osteoporotic animals.…”

Section: Discussionmentioning

confidence: 99%

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

Kang¹,

Choi²,

Kim³

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. In the present study, the complex anti-climacterium potential of standardized pomegranate concentrated solution (PCS) was investigated using bilateral ovariectomy (OVX) female ddY mice. Changes in body weight and gain during experimental periods, food consumption, serum estradiol levels, total body and abdominal fat densities, abdominal fat pads, and uterus weights were observed, along with the histopathology of abdominal fat pads and uterus for anti-obesity and estrogenic effects. In addition, liver weights, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) levels, and histopathological inspections were performed to explore the hepato-protective effects. Serum total cholesterol (TC), low density lipoprotein (LDL), high density lipoprotein, and triglyceride (TG) levels were monitored for hypolipidemic effects with total body and femur mean bone mineral density (BMD), right femur wet, dry and ash weights, strength, serum osteocalcin, bone-specific alkaline phosphatase (bALP) contents, and histological and histomorphometrical analyses for anti-osteoporosis activity. As a result of OVX, notable increases in body weight and gains, food consumption, abdominal fat mass densities, weights of abdominal fat pads deposited in the abdominal cavity, and serum AST, ALT, TC, LDL, TG, and osteocalcin levels were observed, along with decreases in the uterus, liver, and femur weights, mean total body and femur BMD, femur strength, serum bALP, and estradiol levels. In addition, marked hypertrophic alterations in adipocytes located in the deposited abdominal fat pads, liver steatosis, uterine disused atrophic changes, and decreases in bone mass and structures of the femur were also observed in OVX control mice with significant increases in bone resorption markers based on histopathological and histomorphometrical analysis. However, these estrogen-deficient climacterium symptoms were significantly (P<0.05 or P<0.01) inhibited after 84 days of continuous treatment with estradiol and PCS (1, 2 and 4 ml/kg), respectively. The present results suggested that PCS was able to effectively inhibit or refine the climacterium symptoms, including obesity, hyperlipidemia, hepatic steatosis, and osteoporosis, induced by OVX in ddY mice.

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Bone Densitometry: Applications and Limitations

Cited by 75 publications

References 30 publications

Komplikasjoner etter kronisk ryggmargsskade

Komplikasjoner etter kronisk ryggmargsskade

Screening of osteoporosis using calcaneal quantitative ultrasound in a rural population of Jammu, Jammu and Kashmir, India

Anti-climacterium effects of pomegranate concentrated solutions in ovariectomized ddY mice

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