Bone cements for percutaneous vertebroplasty and balloon kyphoplasty: Current status and future developments

He, Zhiwei; Zhai, Qingpan; Hu, Muli; Cao, Chengbin; Wang, Jihui; Yang, Huilin; B, Li

doi:10.1016/j.jot.2014.11.002

Cited by 77 publications

(54 citation statements)

References 70 publications

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“…8). 54 The PMMA-based injectates are nondegradable acrylic bone cements that generate heat during exothermic polymerization. This heat generation may cause tissue damage if it extravasates beyond the cortical margin.…”

Section: Vertebral Augmentation: Vertebroplasty and Kyphoplastymentioning

confidence: 99%

Update on Imaging of Spinal Fixation Hardware

Winegar

Kay

Chadaz

et al. 2019

Semin Musculoskelet Radiol

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This article discusses instrumented spinal surgeries, the radiologic assessment of spinal fixation hardware, and the potential complications of spinal hardware. Radiography is the standard for the postoperative assessment of spinal hardware. Computed tomography and magnetic resonance imaging play a valuable role in the detection of hardware and postsurgical-related complications such as infection, pseudarthrosis, and malpositioned instrumentation. Familiarity with the normal imaging appearance of implanted spinal hardware along with the expected progression of normal postoperative osseous arthrodesis enables recognition of potential complications and helps facilitate appropriate clinical management.

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Section: Vertebral Augmentation: Vertebroplasty and Kyphoplastymentioning

confidence: 99%

Update on Imaging of Spinal Fixation Hardware

Winegar

Kay

Chadaz

et al. 2019

Semin Musculoskelet Radiol

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“…However, the BC poses some significant limitations such as high exothermic temperature (>70°C), fatigue failures, aspetic loosening, and predominant residual free radicals toxicity, which are generated during the in situ polymerization. (He et al, ; Jaiswal et al, ; Kapusetti et al, ; Lewis & Ed, ; Lopez‐Heredia et al, ; Marrs, Andrews, Rantell, & Pienkowski, ; Misra, Kapusetti, Jaiswal, & Maiti, ; Nussbaum, Gailloud, & Murphy, ; Vaishya, Chauhan, & Vaish, ) The exothermic polymerization of BC is processed by radical‐initiated chain growth reactions (He et al, ). During polymerization, the DMPT breaks down and interacts with BPO to form phenyl radical and attacks the double bond of the MMA monomer and leads further polymerization process (Jaiswal et al, ; Lewis & Ed, ; Nussbaum et al, ).…”

Section: Introductionmentioning

confidence: 99%

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Choppadandi

Kapusetti

2019

J Biomedical Materials Res

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Poly(methyl methacrylate) (PMMA) bone cement is the most widely used grouting material in the joint arthroplasties and vertebroplasties. The present investigation has been carried out to scavenge the radicals and monomer by addition of an antioxidant to minimize the toxicity of bone cement (BC). The in silico studies were employed to determine the potent natural antioxidant at physiological conditions. The antioxidant methionine demonstrated a strong binding affinity with free radicals and methyl methacrylate (MMA) monomer than cysteine. The designated amount of methionine was optimized by various assay methods and >2% methionine shows strong scavenging capacity in BC. Moreover, the antioxidant‐loaded BC (ABC) demonstrated similar handling, physicochemical and mechanical properties to pristine bone cement. Significantly, the developed formulation shows superior biological characteristics such as cell proliferation (2 ± 1 BC and 6 ± 1 ABC), adhesion (0.32 ± 0.02 BC and 0.54 ± 0.01 ABC), and cell viability (81 ± 2% BC and 93 ± 1% ABC) toward human osteoblast‐like cells (MG‐63). Therefore, the novel antioxidant bone cement is a potential candidate for various orthopedic applications to eliminate the adverse effects, related to residual toxic radical and monomer in bone cement.

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“…The bone cement used in the operation plays a vital role in the curative effect of BKP. 1 PMMA bone cement has obvious advantages, such as appropriate syringeability, solidication characteristics, mechanical strength and radiopacity. However, its application is limited because of a lack of osteoconduction, biodegradability, osteogenesis, etc.…”

Section: Introductionmentioning

confidence: 99%