Bone breaking infections – A focus on bacterial and mosquito-borne viral infections

Cui, Yan; Wu, Qiu-Wan; Teh, Seoh Wei; Peli, Amira; Bu, Gang; Qiu, Yu; Benelli, Giovanni; Kumar, Suresh

doi:10.1016/j.micpath.2018.06.021

Cited by 11 publications

(5 citation statements)

References 76 publications

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“…Bone-related pathologies are known for several arboviruses, including but not limited to ZIKV, DENV, CHIKV, and RRV (W. Chen et al, 2015;Cui et al, 2018;Sissoko et al, 2009). Other clinically relevant studies have shown that ZIKV exhibits tropism for MSCs which are precursors for bone forming osteoblasts, in the perichondrium of an infected fetus (van der Eijk et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells

Mumtaz

Dudakovic

Nair

et al. 2022

Journal Cellular Physiology

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Arboviruses target bone forming osteoblasts and perturb bone remodeling via paracrine factors. We previously reported that Zika virus (ZIKV) infection of earlystage human mesenchymal stromal cells (MSCs) inhibited the osteogenic lineage commitment of MSCs. To understand the physiological interplay between bone development and ZIKV pathogenesis, we employed a primary in vitro model to examine the biological responses of MSCs to ZIKV infection at different stages of osteogenesis. Precommitted MSCs were infected at the late stage of osteogenic stimulation (Day 7) with ZIKV (multiplicity of infection of 5). We observe that MSCs infected at the late stage of differentiation are highly susceptible to ZIKV infection similar to previous observations with early stage infected MSCs (Day 0). However, in contrast to ZIKV infection at the early stage of differentiation, infection at a later stage significantly elevates the key osteogenic markers and calcium content.Comparative RNA sequencing (RNA-seq) of early and late stage infected MSCs reveals that ZIKV infection alters the mRNA transcriptome during osteogenic induction of MSCs (1251 genes). ZIKV infection provokes a robust antiviral response at both stages of osteogenic differentiation as reflected by the upregulation of interferon responsive genes (n > 140). ZIKV infection enhances the expression of immune-related genes in early stage MSCs while increasing cell cycle genes in late stage MSCs. Remarkably, ZIKA infection in early stage MSCs also activates lipid metabolism-related pathways. In conclusion, ZIKV infection has differentiation stage-dependent effects on MSCs and this mechanistic understanding may permit the development of new therapeutic or preventative measures for bone-related effects of ZIKV infection.

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Section: Discussionmentioning

confidence: 99%

Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells

Mumtaz

Dudakovic

Nair

et al. 2022

Journal Cellular Physiology

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“…The multiple surface adhesion molecules of pathogens involved in this colonization process are termed as microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) [ 60 , 61 ]. Various proteins and polysaccharides in bone extracellular matrix, such as type I collagen, bone sialoprotein, osteopontin, and fibronectin, can specifically recognize and interact with MSCRAMMs to become their binding sites [ 62 ]. These extracellular matrix components, such as fibronectin, are also a bridge between bacteria and bone cells, which can both bind to MSCRAMMs and the cell surface [ 63 ].…”

Section: Damaged Bone Formation Under Infectionmentioning

confidence: 99%

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

Cui

Tian

et al. 2022

Materials Today Bio

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“…Symptoms may last for days or weeks in acute and subacute conditions; however, when they exceed three months, they are considered chronic [5]. It is estimated that more than 40% [6,7] of infected individuals develop a chronic state of the disease with arthritic characteristics, such as bone erosion, enthesopathies, periostitis, and persistent and debilitating joint pain [8,9], which is characteristics, such as bone erosion, enthesopathies, periostitis, and persistent an debilitating joint pain [8,9], which is reflected in the population's public health throug disability-adjusted life years (DALYs) and the economic burden involved [10,11 However, although bone damage in CHIKV infections has been documented, th mechanism involving progression and subsequent injury has not been fully defined.…”

Section: Introductionmentioning

confidence: 99%

Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection

Avila-Trejo,

Rodríguez-Páez,

Alcántara-Farfán

et al. 2023

IJMS

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Chronic cases of chikungunya fever represent a public health problem in countries where the virus circulates. The disease is prolonged, in some cases, for years, resulting in disabling pain and bone erosion among other bone and joint problems. As time progresses, tissue damage is persistent, although the virus has not been found in blood or joints. The pathogenesis of these conditions has not been fully explained. Additionally, it has been considered that there are multiple factors that might intervene in the viral pathogenesis of the different conditions that develop. Other mechanisms involved in osteoarthritic diseases of non-viral origin could help explain how damage is produced in chronic conditions. The aim of this review is to analyze the molecular and cellular factors that could be involved in the tissue damage generated by different infectious conditions of the chikungunya virus.

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Bone breaking infections – A focus on bacterial and mosquito-borne viral infections

Cited by 11 publications

References 76 publications

Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells

Zika virus alters osteogenic lineage progression of human mesenchymal stromal cells

Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration

Multiple Factors Involved in Bone Damage Caused by Chikungunya Virus Infection

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