Bone and tissue allograft use by orthopaedic surgeons

Lavernia, Carlos J.; Malinin, Theodore I.; Temple, H. Thomas; Moreyra, Carlos E

doi:10.1016/j.arth.2003.11.006

Cited by 30 publications

(24 citation statements)

References 20 publications

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“…However, the average total surgical time of 4 hours and 22 minutes was maintained. Lavernia et al (2004) and Rondinelli et al (1994) Animals 05 to 09 showed the highest total surgical harvest time. However, the average total surgical time of 4 hours and 22 minutes was maintained.…”

Section: Discussionmentioning

confidence: 99%

“…The material must be harvested from the corpse as soon as possible postmortem. On an average, material can be collected from a corpse refrigerated at -4°C up to 24 hours, or from a non-refrigerated corpse stored at 20°C up to 12 hours post-mortem (RONDINELLI et al, 1994;LAVERNIA et al, 2004). According to Stefani et al (1989), tissues can be harvested in a sterile manner only when the appropriate surgical procedures are applied.…”

Section: Introductionmentioning

confidence: 99%

“…When aseptic conditions are not observed, secondary sterilization methods, such as irradiation, ethylene oxide or ethanol treatments, or autoclaving, are required (FEOFILOFF; JESUS-GARCIA, 1996;LAVERNIA et al, 2004). The grafts in the following conditions can be preserved: fresh material to be transplanted within 12 hours of harvest, frozen fresh material, lyophilized material that has been subjected to fat and bone marrow removal and subsequently vacuum-dehydrated and demineralized (MORENO;FORRIOL, 2002;MORGAN et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Bacteriological evaluation of bone grafts stored by cryogenic freezing at –24°C from a canine (Canis familiaris) bone bank

et al. 2015

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The scientific basis of bone transplantation was established during the mid-nineteenth century, when the osteogenic properties of the bone and periosteum, beneficial influence of cold preservation of bones, and first conventional attempt to store bones for elective use, were described. A bone bank has several advantages, such as the immediate availability of grafts in large quantities, and different shapes and sizes, and maintenance of osteoinductive activity in grafts. In addition, it reduces patient blood loss, surgical time, and quantity of anesthetics required. Clinical applications include the correction of comminuted fractures, treatment of non-union bones, and replacement of bone loss due to infections or malignancies. The success of these procedures depends on the preservation and integrity of the graft. This study aimed to evaluate the feasibility of maintaining a canine bone bank (Canis familiaris) by quantifying the bacterial contamination of bone grafts preserved at -24°C. The samples were evaluated through a monthly assessment of bacteriological cultures over a period of 6 months. The harvest method was efficient and sterile, reducing the risk of contamination. We conclude that the techniques chosen for the implementation of a bone bank were effective and feasible (use of a common freezer reaching a temperature below -24°C). The viability of the bones was attested during a 6-month period, and the samples demonstrated a 100% sterility rate. Key words: Bone bank, canine, cryogenics, grafts ResumoA base científica do transplante ósseo foi estabelecida na metade do século IX quando foram descritas as propriedades osteogênicas do osso e do periósteo, a influência benéfica do frio na preservação das mesmas, e a primeira tentativa convencional para armazenar ossos para uso eletivo. As vantagens do banco de ossos são a disponibilidade imediata do enxerto em quantidade, forma e tamanhos variados, com a manutenção de sua atividade osteoindutora, e redução do tempo cirúrgico, anestésico e perda sanguínea do paciente. Dentre as aplicações clínicas cita-se a correção de fraturas cominutivas, tratamento de não união óssea e reposição de perda óssea devido a infecções ou neoplasias. O sucesso destes procedimentos depende dos parâmetros de conservação e integridade do enxerto. Este estudo teve como objetivo avaliar a viabilidade da manutenção de banco de ossos de cães (Canis familiaris) quantificando a contaminação bacteriológica dos enxertos ósseos, submetidos à técnica criogênica (-24°C) e avaliados através de realização mensal de culturas bacteriológicas por um período de seis meses. O método de coleta mostrou-se eficiente e propiciou adequada manutenção de esterilidade

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bacteriological evaluation of bone grafts stored by cryogenic freezing at –24°C from a canine (Canis familiaris) bone bank

et al. 2015

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“…In addition, its lack of osteoinductive properties limits its clinical usefulness. Certain of its structural properties have not been replicated by any of the synthetic materials, and thus considerable usage of allograft was noticed during this investigation [18,22].…”

Section: Discussionmentioning

confidence: 99%

The Clinical Use of Allografts, Demineralized Bone Matrices, Synthetic Bone Graft Substitutes and Osteoinductive Growth Factors: A Survey Study

Bostrom

Seigerman

2005

HSS Journal®: The Musculoskeletal Journal of Hospital for Speci

126

104

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The emergence of new bone grafting options and alternatives has led to significant uncertainty when determining the most appropriate product for surgical procedures requiring bone graft in orthopedics. Allografts, demineralized bone matrices, synthetic bone graft substitutes, and osteoinductive growth factors are all viable options, yet there is a lack of data reporting clinical usage of these products. This correspondence reports on the use of bone grafting products at the Hospital for Special Surgery for a 27-month period and makes recommendations based on surgical usage, safety, and cost. Approximately half (48.6%) of all bone graft substitutes were implanted during spinal surgery. Arthroplasty, trauma, and foot/hand cases all used considerable amounts of bone grafting products as well (20.1%, 19.0%, 12.1%, respectively). Considerable differences were noticed in usage of bone grafting products among each orthopedic discipline. Of all bone graft substitutes used in arthroplasty, 14.4% were demineralized bone matrices, whereas 56.8% were allografts. Demineralized bone matrix grafts were used in 82% of trauma surgery and 89% of foot/hand cases. An increase in synthetic bone graft alternatives was noticed near the end of our investigation period.

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“…Nos últimos anos, o emprego dos aloenxertos, principalmente em cirurgias ortopédicas mostram resultados promissores (Boldt, 2001;Janssen, 2001;Nesse et al, 2003;Lavernia et al, 2004;Schreurs et al, 2004;Schreurs et al, 2005) (Rudelli et al, 1992;Croci et al, 2003b;Cabrita, 2004). Em consonância com estes pesquisadores e considerando a atual realidade, escolhemos como objeto de estudo o enxerto homólogo.…”

Section: Nú M E Ro D E O S T E O B La S T O S /á Re a T O T A L D Ifeunclassified

Efeito da utilização de plasma rico em plaquetas na osteointegração dos enxertos ósseos homólogos criopreservados: estudo histomorfométrico em coelhos

Augusto¹,

Santos²

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Bone and tissue allograft use by orthopaedic surgeons

Cited by 30 publications

References 20 publications

Bacteriological evaluation of bone grafts stored by cryogenic freezing at –24°C from a canine (Canis familiaris) bone bank

Bacteriological evaluation of bone grafts stored by cryogenic freezing at –24°C from a canine (Canis familiaris) bone bank

The Clinical Use of Allografts, Demineralized Bone Matrices, Synthetic Bone Graft Substitutes and Osteoinductive Growth Factors: A Survey Study

Efeito da utilização de plasma rico em plaquetas na osteointegração dos enxertos ósseos homólogos criopreservados: estudo histomorfométrico em coelhos

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