Bone allografts

Delloye, Christian; Cornu, Olivier; Druez, Vincent; Barbier, Olivier

doi:10.1302/0301-620x.89b5.19039

Cited by 348 publications

(128 citation statements)

References 65 publications

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“…The gold standard against which all bone graft substitutes must be compared remains autologous bone graft 25,26. This is able to provide three core attributes for bone healing: osteoconduction, osteoinduction and osteogenesis.…”

Section: The Ideal Bone Substitutementioning

confidence: 99%

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ferguson

Diefenbeck

McNally

2017

J. Bone Joint Infect.

123

153

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Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous defect as they dissolve away. A dissolving ceramic antibiotic carrier also raises the possibility of single stage surgery with definitive closure and avoids the need for subsequent surgery for spacer removal.In this article we provide an overview of the properties of various biodegradable ceramics, including calcium sulphate, the calcium orthophosphate ceramics, calcium phosphate cement and polyphasic carriers. We summarise the antibiotic elution properties as investigated in previous animal studies as well as the clinical outcomes from clinical research investigating their use in the surgical management of chronic osteomyelitis.Calcium sulphate pellets have been shown to be effective in treating local infection, although newer polyphasic carriers may support greater osseous repair and reduce the risk of further fracture or the need for secondary reconstructive surgery. The use of ceramic biocomposites to deliver antibiotics together with BMPs, bisphosphonates, growth factors or living cells is under investigation and merits further study.We propose a treatment protocol, based on the Cierny-Mader classification, to help guide the appropriate selection of a suitable ceramic antibiotic carrier in the surgical treatment of chronic osteomyelitis.

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Section: The Ideal Bone Substitutementioning

confidence: 99%

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ferguson

Diefenbeck

McNally

2017

J. Bone Joint Infect.

123

153

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“…The risk of disease transmission is a significant concern with the use of allograft [29]. Rigorous donor and serological screening and sterilization is employed to prevent bacterial and viral (human immunodeficiency virus, hepatitis viruses) infection, rendering risk of transmission remote [29].…”

Section: Allograft-based Bone Graft Substitutesmentioning

confidence: 99%

Bone graft substitutes in anterior cervical discectomy and fusion

2009

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Anterior cervical discectomy with fusion is a common surgical procedure for patients suffering pain and/ or neurological deficits and unresponsive to conservative management. For decades, autologous bone grafted from the iliac crest has been used as a substrate for cervical arthrodesis. However patient dissatisfaction with donor site morbidity has led to the search for alternative techniques. We present a literature review examining the progress of available grafting options as assessed in human clinical trials, considering allograft-based, synthetic, factor-and cell-based technologies.

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“…This uses patient's own autologous bone, which provides a natural substrate for new osteogenic cells to grow into the graft enabling the healing and re-modeling of the injured bone [7]. However, a major drawback with autografts involves pain and infection around the donor bone area, the limitation in donor bone volume (only 20 cm 3 ) and incomplete integration of the grafted bone [8]. Thus bone tissue engineering seems to be a promising therapeutic alternative as it would drastically eradicate the pain and overcome the limitation caused by autografts.…”

Section: Introductionmentioning

confidence: 99%

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

Bhattacharya¹,

Ghayor²,

Weber³

2016

Transfus Med Hemother

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2500 years ago, Hippocrates realized that bone can heal without scaring. The natural healing potential of bone is, however, restricted to small defects. Extended bone defects caused by trauma or during tumor resections still pose a huge problem in orthopedics and cranio-maxillofacial surgery. Bone tissue engineering strategies using stem cells, growth factors, and scaffolds could overcome the problems with the treatment of extended bone defects. In this review, we give a short overview on bone tissue engineering with emphasis on the use of adipose tissue-derived stem cells and small molecules.

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Bone allografts

Cited by 348 publications

References 65 publications

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Bone graft substitutes in anterior cervical discectomy and fusion

The Use of Adipose Tissue-Derived Progenitors in Bone Tissue Engineering - a Review

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