Bone-Albumin filling decreases donor site morbidity and enhances bone formation after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts

Schandl, Károly; Horváthy, Dénes B.; Doros, Attila; Majzik, Ernő; Schwarz, Charlotte; Csönge, Lajos; Abkarovits, Géza; Bucsi, László; Lacza, Zsombor

doi:10.1007/s00264-016-3246-8

Cited by 33 publications

(35 citation statements)

References 25 publications

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“…This animal study has recently been confirmed in humans. First as a case series, then as a double‐blind controlled study we shown that serum albuin coated bone allografts show excellent remodeling characteristics in patients . Another widely used bone substitute was also tested with albumin coating.…”

Section: Local Albumin Administrationmentioning

confidence: 98%

Serum albumin as a local therapeutic agent in cell therapy and tissue engineering

et al. 2016

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Albumin is a major plasma protein that has become ubiquitous in regenerative medicine research. As such, many studies have examined its structure and advantageous properties. However, a systematic and comprehensive understanding of albumin's role, capabilities and therapeutic potential still eludes the field. In the present work, we review how albumin is applied in tissue engineering, including cell culture and storage, in vitro fertilization and transplantation. Furthermore, we discuss how albumin's physiological role extends beyond a carrier for metal ions, fatty acids, pharmacons and growth factors. Albumin acts as a bacteriostatic coating that simultaneously promotes attachment and proliferation of eukaryotic cells. These properties with the combination of free radical scavenging, neutrophil activation and as a buffer molecule already make the albumin protein beneficial in healing processes supporting functional tissue remodeling. Nevertheless, recent data revealed that albumin can be synthesized by osteoblasts and its local concentration is raised after bone trauma. Interestingly, by increasing the local albumin concentration in vivo, faster bone healing is achieved, possibly because albumin recruits endogenous stem cells and promotes the growth of new bone. These data also suggest an active role of albumin, even though a specific receptor has not yet been identified. Together, this discussion sheds light on why the extravascular use of the albumin molecule is in the scope of scientific investigations and why it should be considered as a local therapeutic agent in regenerative medicine. © 2016 BioFactors, 43(3):315-330, 2017.

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Section: Local Albumin Administrationmentioning

confidence: 98%

Serum albumin as a local therapeutic agent in cell therapy and tissue engineering

et al. 2016

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“…After ethanol sterilization, bone grafts were submerged in sterile 10% human serum albumin solution for 60 seconds (low-salt-content Biotest human albumin infusion, Biotest Pharma GmbH, Dreieich, Germany). Preservation of the bone graft was finished with a second freeze-drying process [16].…”

Section: Albumin Impregnated Allograft Preparationmentioning

confidence: 99%

“…Allogenic bone overcomes donor site morbidity, and its available quantity is not restricted by patient-specific anatomical characteristics of the donor regions selected for bone harvesting. According to preclinical studies, albumin impregnation induces mesenchymal stem cell growth on the surface of freeze-dried bone allograft [14][15][16]. Studies show that allografts completely remodel into the newly formed bone of the maxilla when used as a graft material for sinus floor elevation [17,18].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Micro-Computed Tomography and Cone-Beam Computed Tomography in the Assessment of Bone Quality and a Long-Term Volumetric Study of the Augmented Sinus Grafted with an Albumin Impregnated Allograft

Kivovics

Szabó

Németh

et al. 2020

JCM

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The purpose of our study was to compare micromorphometric data obtained by cone-beam computed-tomography (CBCT) and microcomputed-tomography (micro-CT) of the augmented sinus and to evaluate the long-term stability of the bone gain achieved using BoneAlbumin. Sinus lifts, and after 6-months, healing bone-biopsy and implant placement were carried out. Specimens were analyzed by micro-CT. A total of 16 samples were collected from nine patients (mean age 54.7 ± 6.5 years). Pre-, postoperative, and 3-year control CBCT-data were registered to determine from where the biopsy samples were harvested. Micromorphometric variables were calculated from the micro-CT- and CBCT-data, and their correlation was determined by Spearman’s test. The volume of augmented bone was calculated at the time of implant placement and after 3 years. A positive correlation was found between bone-volume fraction, trabecular-separation, open-, and total-porosity, while a negative correlation was found between trabecular-thickness obtained from CBCT- and micro-CT-data (p < 0.05). Mean volumetric reduction of 39.28% (11.88–60.02%) was observed. Correlation of CBCT- and micro-CT-data suggested that micromorphometric analysis of CBCT reconstructions of the augmented sinuses provided reliable information on the microarchitecture of augmented bone. CBCT as a modality might be adequate in the analysis of bone quality in the augmented sinus. At the 3-year, control sinus grafts showed volumetric stability.

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“…Serum albumin‐coated bone allograft (BoneAlbumin) has been intensively investigated lately, with outcomes data demonstrating an ability of BoneAlbumin to facilitate new bone formation in non‐union and critical size defect models in rats (Horvathy, Vacz, et al, ; Skaliczki et al, ; Weszl et al, ). BoneAlbumin was also shown to decrease donor site morbidity and enhance bone formation after anterior cruciate ligament reconstruction with bone‐patellar tendon‐bone autografts (Schandl et al, ). Moreover, in a thorough review article, the albumin molecule was shown to have an important and potentially active but not yet completely understood role in bone regeneration (Horvathy, Simon, et al, ).…”

Section: Introductionmentioning

confidence: 99%

Serum albumin‐coated bone allograft (BoneAlbumin) results in faster bone formation and mechanically stronger bone in aging rats

Horváthy

Schandl

Schwarz

et al. 2019

J Tissue Eng Regen Med

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Serum albumin‐coated bone allografts (BoneAlbumin) have successfully supported bone regeneration in various experimental models by activating endogenous progenitors. However, the effect of tissue aging, linked to declining stem cell function, has yet to be explicitly examined within the context of BoneAlbumin's regenerative capacity. Stem cell function was tested with an in vitro attachment assay, which showed that albumin coating increases stem cell attachment on demineralized bone surfaces in an aging cell population. Bone regeneration was investigated in vivo by creating critical size bone defects on the parietal bones of aging female rats. Demineralized bone matrices with and without serum albumin coating were used to fill the defects. Bone regeneration was determined by measuring the density and the size of the remaining bone defect with computed tomography (CT). Microcomputed tomography (MicroCT) and mechanical testing were performed on the parietal bone explants. In vivo CT and ex vivo microCT measurements showed better regeneration with albumin‐coated grafts. Additionally, the albumin‐coated group showed a twofold increase in peak fracture force compared with uncoated allografts. In the present study, serum albumin‐coated demineralized bone matrices successfully supported faster and functionally superior bone regeneration in aging rats. Because stem cell function, a key contributor of bone remodelling, decreases with age and serum albumin is an effective activator of endogenous progenitor cells, this method could be an effective and safe adjuvant in bone regeneration of aging adult and osteo‐compromised populations.

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Bone-Albumin filling decreases donor site morbidity and enhances bone formation after anterior cruciate ligament reconstruction with bone-patellar tendon-bone autografts

Abstract: Results from the present study indicate that donor site pain, a disturbing long-term side effect of bone-patellar tendon-bone surgery, is significantly reduced if bone buildup in the patella and the tibia is augmented by serum albumin-coated bone allografts.

Cited by 33 publications

References 25 publications

Serum albumin as a local therapeutic agent in cell therapy and tissue engineering

Serum albumin as a local therapeutic agent in cell therapy and tissue engineering

Comparison between Micro-Computed Tomography and Cone-Beam Computed Tomography in the Assessment of Bone Quality and a Long-Term Volumetric Study of the Augmented Sinus Grafted with an Albumin Impregnated Allograft

Serum albumin‐coated bone allograft (BoneAlbumin) results in faster bone formation and mechanically stronger bone in aging rats

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