Bonding Organics to Ti Alloys:  Facilitating Human Osteoblast Attachment and Spreading on Surgical Implant Materials Corrections

Organophosphonate Self-Assembled Monolayers for Gate Dielectric Surface Modification of Pentacene-Based Organic Thin-Film Transistors: A Comparative Study

“…Phosphonate SAMs adhere strongly to the substrate surface 17,18 and are ordered, homogeneous, 15 and versatile for subsequent chemical modification. 19,20 They have molecular densities close to those found in single crystals of the film constituents, 15,19 are resistant to removal by moisture and oxidation, 13 and are stable in electronically active environments. 14,16,21 The T-BAG method has been used successfully for a wide variety of oxideterminated substrates and phosphonic acid structural motifs, 14,16,18 so virtually any phosphonic acid may be deposited onto any gate dielectric oxide material.…”

Self-assembled monolayers of phosphonates promote primary chondrocyte adhesion to silicon dioxide and polyvinyl alcohol materials

“…[35] By increasing the affinity of cells to material surfaces, the integration of implanted devices may be enhanced, which has been demonstrated for integration of surfaces with bone via osteoblast adhesion, in vitro and in vivo. [31,37] SAMP modification can be performed on nearly any material surface that possesses repeating electron-rich functionality. Surface modification with SAMPs has been reported to increase cell affinity to polymer surfaces of PET, PEEK, and nylon 6,6, as well as other metal oxide surfaces, and osteoblasts, fibroblasts, and stems cells have been shown to respond positively (increased adhesion) to surfaces modified with SAMPs of bisphosphonic aicds, such as termination 4 used in this study.…”

“…Surface modification with SAMPs has been reported to increase cell affinity to polymer surfaces of PET, PEEK, and nylon 6,6, as well as other metal oxide surfaces, and osteoblasts, fibroblasts, and stems cells have been shown to respond positively (increased adhesion) to surfaces modified with SAMPs of bisphosphonic aicds, such as termination 4 used in this study. [30][31][32][33][34][35][36] Spatial modification of surfaces with 4 have been shown to control cell adhesion and spatially direct cell proliferation, such that the adherent cells developed spatially aligned ECM and direct neurite outgrowth. [38,39,54,55] It should be noted that the α,ω-bisphosphonic acid used in the work, butane-1,4-diphosphonic acid, is not a therapeutic bisphosphonic acid, as those commonly used to treat inflammatory joint diseases or osteoporosis.…”

“…[21][22][23][24][25][26][27][28][29] One coating in particular, self-assembled monolayer of phosphonates (SAMPs) can increase the adhesion of fibroblasts, osteoblasts, and stem cells, to both metal and polymer surfaces, without changing bulk mechanical properties or surface roughness. [30][31][32][33][34][35][36] The termination group added to SAMPs can be controlled depending on the desired adhesion, but α,ω-bisphosphonic acids have been used most commonly. SAMP-coated titanium alloy surfaces terminated with an α,ω-bisphosphonic acid and Arg-Gly-Asp (RDG) tripeptide have demonstrated increased in vivo bone deposition and superior interfacial strength compared to hydroxyapatite coatings.…”

Titanium-Tethered Vancomycin Prevents Resistance to Rifampicin in Staphylococcus aureus in vitro

“…Antibiotics such as ampicillin [10], daptomycin [11] and vancomycin [12]–[16] maintain bioactivity when covalently linked (tethered) to a solid surface. Several techniques have been described for the covalent linkage to a titanium oxide surface, where the organic-metal connection is made through silane [17], phosphate [18], phosphonate [19] or catechol [20] linkers. One strategy involving vancomycin is the covalent bonding of the antibiotic to a titanium alloy surface through a short polyethylene (PEG) tether using a silane linker [14].…”