Bonding capacity in bone of HIP‐processed HA‐coated titanium: Mechanical and histological investigations

Wie, Henrik; Herø, H.; Solheim, Tore; Kleven, Erik; Rørvik, A. M.; Haanæs, Hans R.

doi:10.1002/jbm.820291116

Cited by 15 publications

(4 citation statements)

References 13 publications

(1 reference statement)

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“…Indeed, HA is well known to form intimate attachments with both hard and soft tissues-a feature that has been exploited to enhance the attachment of metallic prostheses. 26,27 Even though HA is the calcium phosphate ceramic most frequently used as a coating and synthetic bone replacement, it is virtually insoluble under physiological conditions, meaning that degradation of the ceramic and replacement by native tissue is slow (*5 vol % per year). Complete mechanical incorporation of tissueengineered ligaments will only occur when the ceramic material is replaced with endogenous bone.…”

Section: Introductionmentioning

confidence: 99%

Engineering anIn VitroModel of a Functional Ligament from Bone to Bone

Paxton

Grover

Baar

2010

Tissue Engineering Part A

131

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For musculoskeletal tissues that transmit loads during movement, the interfaces between tissues are essential to minimizing injury. Therefore, the reproduction of functional interfaces within engineered musculoskeletal tissues is critical to the successful transfer of the technology to the clinic. The goal of this work was to rapidly engineer ligament equivalents in vitro that contained both the soft tissue sinew and a hard tissue bone mimetic. This goal was achieved using cast brushite (CaHPO(4)·2H(2)O) anchors to mimic bone and a fibrin gel embedded with fibroblasts to create the sinew. The constructs formed within 7 days. Fourteen days after seeding, the interface between the brushite and sinew could withstand a stress of 9.51 ± 1.7 kPa before failure and the sinew reached a Young's modulus value of 0.16 ± 0.03 MPa. Treatment with ascorbic acid and proline increased the collagen content of the sinew (from 1.34% ± 0.2% to 8.34% ± 0.37%), strength of the interface (29.24 ± 6 kPa), and modulus of the sinew (2.69 ± 0.25 MPa). Adding transforming growth factor-β resulted in a further increase in collagen (11.25% ± 0.39%), interface strength (42 ± 8 kPa), and sinew modulus (5.46 ± 0.68 MPa). Both scanning electron and Raman microscopy suggested that the interface between the brushite and sinew mimics the in vivo tidemark at the enthesis. This work describes a major step toward the development of tissue-engineered ligaments for the repair of ligament ruptures in humans.

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Section: Introductionmentioning

confidence: 99%

Engineering anIn VitroModel of a Functional Ligament from Bone to Bone

Paxton

Grover

Baar

2010

Tissue Engineering Part A

131

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“…This value is much less than the 30-60% typically reported in the literature for implants placed in cortical bone. [43][44][45][46][47][48] We believe that this is due to both the site of implant placement and the method used for measuring bone-implant contact. As previously stated, the bone in the nasal region was only 1-2 mm thick.…”

Section: Discussionmentioning

confidence: 99%

Implant-borne suture expansion in rabbits: A histomorphometric study of the supporting bone

Parr

Garetto

Wohlford

et al. 1999

J. Biomed. Mater. Res.

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Osseointegrated implants have a large potential for diverse clinical applications, including support for sutural expansion and facial prostheses. The objectives of this study were to evaluate: (1) the histomorphometric response of thin cortical bone to implant placement and (2) whether loading of the bone surrounding these implants affects osseointegration as evaluated by histomorphometry. Eighteen New Zealand White rabbits had two titanium implants placed bilaterally in the anterior surface of their nasal bones. The rabbits were divided into an unloaded control group, one experimental group loaded at 1 Newton (N), and another loaded at 3 N. Fluorescent labels were used to mark areas of active bone formation. All rabbits were euthanized after 12 weeks of loading. Stereological point-hit and line-intercept methods were used to measure bone volume, direct bone-implant contact, new bone volume, and bone turnover rate in the bone surrounding the implants. All the implants remained stable during the loading period. A factorial ANOVA with repeated measures was used to compare the variables. The only significant difference among the three groups was a higher bone volume in the lateral coronal far region in the control group (p < 0. 05). Within all groups, bone volume (p < 0.002), turnover rate (p < 0.001), and percent of new bone (p < 0.05) were higher within 1 mm of the implant compared to 1-3 mm away. This may be due to the increased stress and strain in the bone adjacent to the implant. This study indicates that there are no detrimental effects of loading on osseointegration when implants placed in the thin facial cortices are used as anchors for sutural expansion.

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“…A variant of the sintering method is hot isostatic pressing at a maximum temperature of 850 °C. The coatings are applied under high pressure which has been shown to increase bonding strength 282,411 .…”

Section: Application Methodsmentioning

confidence: 99%