Bonded cellulose-derived high-performance liquid chromatography chiral stationary phases I. Influence of the degree of fixation on selectivity

Synthesis of covalently bonded cellulose derivative chiral stationary phases with a bifunctional reagent of 3-(triethoxysilyl)propyl isocyanate

“…It can be seen 6 5 21 CMB: 1725 (C=O), 1600 and 840 (C H ), cm . In that the mass percentage of the cellulose derivatives 6 5 addition, the peaks due to hydroxyl groups at around onto the silica gel was somewhat lower than those in 21 3500 cm were found on FT-IR spectrum for the previous reports [10,12]. It may be possibly attribucellulose 2,3-bisderivatives.…”

“…Up to now, various methods have CSPs are commercially available [2][3][4][5][6][7]. Although a been successfully developed to prepare the bondedvery large range of enantiomers have been separated type phases reported by Okamoto and co-workerś on these coated CSPs, the main drawback of these [9][10][11], Minguillon et al [12][13][14], and others [8]. phases is related to the solubility of chiral selectors Recently, we have successfully synthesized a compoin a number of solvents, thus the solvents used as the site type of CSP by chemically bonding two different cellulose derivatives onto a silica matrix [15].…”

Synthesis and characteristics of composite chiral stationary phases based on cellulose derivatives

“…In some cases, the better chiral resolution could be obtained on the bonded phases when those solvents were adopted as a component of the mobile phases [11]. Methods for synthesizing the chemically fixed polysaccharide-based CSPs have been successfully developed by Okamoto et al [11,12], Minguillón et al [13,14], and others [7,15]. Recently, we have synthesized bonded cellulose trisphenylcarbamate CSPs for separation of enantiomers by means of a bisfunctional reagent method with the adoption of the underivatized silica gel as the base matrix instead of the aminopropylsilica gel used traditionally [16].…”

The Development and Application of Cellulose-Based Stationary Phases in Stereoselective Separation of Chiral Pesticides

“…The important decrease in the recognition ability of these CSPs could be attributed to their higher degree of reticulation. More heterogeneous reaction sites of allysilica gel with cellulose derivatives can result in lower degree of reticulation in CSPs and therefore improve their recognition ability [24].…”