Bombesin acts to suppress feeding behavior and alter serum growth hormone in goldfish

Periprandial changes in growth hormone release in goldfish: role of somatostatin, ghrelin, and gastrin-releasing peptide

“…In fish, BBS-like peptides have been detected within neurons and endocrine cells of the gastrointestinal tract, cardiovascular system, and brain (Ref. 25 and references cited therein). BBS-like peptide has also been shown to be involved in the regulation of gut motility and visceral activity in several fish species (5,31).…”

“…BBS-like peptide has also been shown to be involved in the regulation of gut motility and visceral activity in several fish species (5,31). In goldfish, BBS acutely suppresses food intake and also stimulates GH release when administered either intraperitoneally or intracerebroventricularly (25,26). Furthermore, intraperitoneal administration of BBS reduces PSS-I and PSS-II but not PSS-III gene expression in goldfish forebrain (11).…”

“…On the other hand, GH release is stimulated by dopamine and a number of neuropeptides (57), including ghrelin (75). Notably, several of these neuropeptides such as CCK and bombesin (BBS)/gastrin-releasing peptide (GRP) and ghrelin have also been shown to regulate food intake in fish as well as in mammals (25,59,73,74). In goldfish, a short-term relationship between circulating serum GH levels and feeding has been demonstrated (25).…”

“…Notably, several of these neuropeptides such as CCK and bombesin (BBS)/gastrin-releasing peptide (GRP) and ghrelin have also been shown to regulate food intake in fish as well as in mammals (25,59,73,74). In goldfish, a short-term relationship between circulating serum GH levels and feeding has been demonstrated (25). When fed a 2% wet body wt ration on a regular schedule, goldfish exhibit an acute elevation in serum GH at 30 min after feeding (25).…”

“…In goldfish, a short-term relationship between circulating serum GH levels and feeding has been demonstrated (25). When fed a 2% wet body wt ration on a regular schedule, goldfish exhibit an acute elevation in serum GH at 30 min after feeding (25). It was speculated that CCK and/or BBS/GRP might integrate the regulation of satiation and the postprandial increase in circulating GH levels (45).…”