Regulation of Food Intake by Neuropeptides and Hormones

Pedro, Nuria de; Björnsson, Björn Thrándur

doi:10.1002/9780470999516.ch12

Cited by 35 publications

(26 citation statements)

References 157 publications

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“…Our data support previous studies in rats, which demonstrated that part of the anorectic activity of leptin could be mediated by inhibition of noradrenergic and dopaminergic fibres in the hypothalamus (Brunetti et al 1999). Particularly, leptin could probably reduce food intake by decreasing noradrenergic activity in fish hypothalamus, keeping in mind that NE stimulates food intake in fish (de Pedro & Björnsson 2001. These results are consistent with findings in mammals, where NE appears to be involved in feeding regulation by leptin (Francis et al 2004).…”

Section: Discussionsupporting

confidence: 93%

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Pedro¹,

Martínez‐Álvarez²,

Delgado³

2006

Journal of Endocrinology

132

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The purpose of the present study was to elucidate the possible role of leptin in food intake and body weight regulation in goldfish. We examined the effects of i.c.v. or i.p. acute leptin administration on food intake in fooddeprived goldfish at different time intervals post-injection (0-2, 2-8 and 0-8 h). Food intake was reduced by i.p. administered leptin (1 µg) at 8 h post-injection, without statistically significant differences after i.c.v. treatment. The present study shows for the first time in a teleost that chronic (10 days) leptin treatment (i.p.) reduces food intake, body weight gain, specific growth rate and food efficiency ratio. Moreover, lipid and carbohydrate metabolism seems to be regulated by leptin in fish.Chronic leptin treatment increased lipid mobilization and carbohydrate storage as hepatic and muscle glycogen. Finally, leptin could mediate its actions on energy homeostasis in fish, at least in part, through interactions with hypothalamic catecholamines, since chronic leptin treatment reduced both hypothalamic noradrenergic and dopaminergic turnover without significant modifications in hypothalamic serotoninergic and neuropeptide Y (NPY) systems. In summary, our results suggest that leptin can regulate feeding behaviour and body weight homeostasis in fish.

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Section: Discussionsupporting

confidence: 93%

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Pedro¹,

Martínez‐Álvarez²,

Delgado³

2006

Journal of Endocrinology

132

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“…These include neuropeptides involved in regulation of feed intake and appetite, such as corticotrophin-releasing factor (CRF), bombesin, cholecystokinin (CCK), galanin, opiod peptides and neuropeptide Y (for review, see De Pedro and Björnsson, 2001). Also, hormones regulating appetite, growth and metabolism, in particular, growth hormone (GH), insulinlike growth factor I (IGF-I) and somatostatin may have indirect effects on lipid homeostasis, in addition to the direct lipolytic effects of GH on the liver in salmonids (for review see, (Bjornsson, 1997;Bjornsson et al 2002;Perez-Sanchez et al 2002).…”

Section: Other Hormonesmentioning

confidence: 99%

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Leaver

Bautista

Björnsson

et al. 2008

Reviews in Fisheries Science

226

192

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Lipids are the predominant source of energy for fish. The mechanisms by which fish allocate energy from lipids, for metabolism, development, growth and reproduction are critical for understanding key life history strategies and transitions. Currently, the major lipid component in aquaculture diets is fish oil (FO), derived from wild capture fisheries that are exploited at their maximum sustainable limit. The increasing demand from aquaculture for FO will soon exceed supply and threaten the viability of aquaculture. Thus, it is essential to minimize FO use in aquaculture diets. This might be achieved by a greater understanding of lipid storage and muscle growth, or the identification of alternatives to FO in feeds. This review focuses on recent research applying molecular and genomic techniques to the study of fin-fish lipid metabolism from an aquaculture perspective. Accordingly, particular emphasis will be given to fatty acid metabolism and to highly unsaturated fatty acid (HUFA) biosynthesis, and to the transcriptional mechanisms and endocrine factors that regulate these processes in fish. Comparative studies of gene function and distribution are described which, when integrated with recent fish genome sequence information, provide insights into lipid homeostasis and the outcomes associated with the replacement of FO in fish diets.

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“…Goldfish, Carassius auratus (Linnaeus 1758), is one of the most studied teleost species with regard to feeding regulation (Volkoff et al, 2009). Neuropeptide Y (NPY), orexins and ghrelin are examples of powerful orexigenic factors in this species, whereas cholecystokinin (CCK) and leptin act as anorexic signals (de Pedro and Björnsson, 2001;Volkoff et al, 2009). Dopamine (DA) and serotonin (5-HT) systems have been found to inhibit food intake, while noradrenaline (NA) stimulates it (de Pedro et al, 1998a;de Pedro et al, 1998b).…”

Section: Introductionmentioning

confidence: 99%

Role of oleoylethanolamide as a feeding regulator in goldfish

Tinoco

Armirotti

Isorna

et al. 2014

Journal of Experimental Biology

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Oleoylethanolamide (OEA) is a bioactive lipid mediator, produced in the intestine and other tissues, which is involved in energy balance regulation in mammals, modulating feeding and lipid metabolism. The purpose of the present study was to investigate the presence and possible role of OEA in feeding regulation in goldfish (Carassius auratus). We assessed whether goldfish peripheral tissues and brain contain OEA and their regulation by nutritional status. OEA was detected in all studied tissues (liver, intestinal bulb, proximal intestine, muscle, hypothalamus, telencephalon and brainstem). Food deprivation (48 h) reduced intestinal OEA levels and levels increased upon re-feeding, suggesting that this compound may be involved in the short-term regulation of food intake in goldfish, as a satiety factor. Next, the effects of acute intraperitoneal administration of OEA on feeding, swimming and plasma levels of glucose and triglycerides were analysed. Food intake, swimming activity and circulating triglyceride levels were reduced by OEA 2 h post-injection. Finally, the possible interplay among OEA and other feeding regulators (leptin, cholecystokinin, ghrelin, neuropeptide Y, orexin and monoamines) was investigated. OEA actions on energy homeostasis in goldfish could be mediated, at least in part, through interactions with ghrelin and the serotonergic system, as OEA treatment reduced ghrelin expression in the intestinal bulb, and increased serotonergic activity in the telencephalon. In summary, our results indicate for the first time in fish that OEA could be involved in the regulation of feeding, swimming and lipid metabolism, suggesting a high conservation of OEA actions in energy balance throughout vertebrate evolution.

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Regulation of Food Intake by Neuropeptides and Hormones

Cited by 35 publications

References 157 publications

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Acute and chronic leptin reduces food intake and body weight in goldfish (Carassius auratus)

Towards Fish Lipid Nutrigenomics: Current State and Prospects for Fin-Fish Aquaculture

Role of oleoylethanolamide as a feeding regulator in goldfish

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