Bofutsushosan, a Traditional Chinese Formulation, Prevents Intimal Thickening and Vascular Smooth Muscle Cell Proliferation Induced by Balloon Endothelial Denudation in Rats

Ohno, Kenji; Chung, Hwa Jin; Maruyama, Ikuro; Tani, Tohru

doi:10.1248/bpb.28.2162

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…In addition, the R 2 level in the multivariate analysis was relatively low (R 2 ¼ 0.185) ( Table 5) and the mechanism of the beneficial effect of BOF on ambulatory BP variability remains to be determined. Since the improvement in short-term BP variability conferred by BOF add-on therapy on short-term BP is independent of its anti-obesity effect and BP reduction, other factors such as its putative effects on vasoactive substance, endothelial function and/or renal sodium handling would be possible candidates involved [48,49]. We indeed reported that the BOF-mediated improvement in adipose tissue function by amelioration of adipokine dysregulation as well as the reduction of food intake by the appetite-inhibitory property of BOF through suppression on the ghrelin system contribute to the BP lowering effect and favorable metabolic modulation by BOF in a mouse model of human metabolic disorders with obesity [7].…”

Section: Discussionmentioning

confidence: 99%

Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

et al. 2015

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“…Bofutsushosan (BOF), typical Chinese medicine, has been reported to improve atherosclerosis [3], obesity [4][5][6], hypertension, hyperglycemia [6], fatty liver [7,8] visceral fat and insulin resistance [9] in both clinical practice and animal examinations [5]. BOF has the potential to prevent adipogenesis in rat white adipocytes via modulation of gene expression levels [10].…”

Section: Introductionmentioning

confidence: 99%

Effects of Single Administered Bofutsushosan-Composed Crude Drugs on Diabetic Serum Parameters in Streptozotocin-Induced Diabetic Mice

Yu¹,

Takahashi²,

Nomura³

et al. 2013

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The 18 crude drugs in Bofutsushosan (BOF: Pulvis ledebouriellae compositae: 防風通聖散) are separated into 6 groups such as diaphoretic, cathartic, antidote, antipyretic, neutralizer and diuretic groups. The effects of single administered BOF and composed crude drugs in 6 groups were investigated on the levels of diabetic parameters (serum glucose, insulin, triglyceride and cholesterol) in streptozotocin-induced diabetic mice. The anti-hyperglycemic action of BOF was depended on Ephedrae Herba, Saposhnikoviae Radix and Schizonepetae Spica in diaphoretic group, Forsythiae Fructus, Saposhnikoviae Radix, Schizonepetae Spica and Cnidii Rhizoma in antidote group, Scutellariae Radix, Gardeniae Fructus and Gypsum Fibrosum in antipyretic group and Paeoniae Radix in neutralizer group. In these crude drugs, Ephedrae Herba, Saposhnikoviae Radix, Schizonepetae Spica, Forsythiae Fructus, Scutellariae Radix, Gypsum Fibrosum and Paeoniae Radix increased serum insulin level, but Cnidii Rhizoma and Gardeniae Fructus did not affect serum insulin level. From these results, it suggested that anti-hyperglycemic action of BOF was through insulin-dependent and insulin independent manners. The lowering effect of BOF on serum triglyceride level was dependent on actions of Platycodi Radix in antidote and diuretic groups and Gardeniae Fructus in antipyretic group. The lowering effect of Gardeniae Fructus was parallel with its anti-hyperglycemic action. The lowering effect of BOF on high serum triglyceride level also included both direct action and indirect action. The reducing effect of BOF on serum cholesterol level was observed together with the actions of Ephedrae Herba and Zingiberis Rhizoma in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group. The lowering effects of Ephedrae Herba, Schizonepetae Spica and Paeoniae Radix on serum cholesterol level were parallel with their anti-hyperglycemic actions. Zingiberis Rhizoma in diaphoretic group might be direct reducing effect on serum cholesterol level but no serum glucose level. The Ephedrae Herba in diaphoretic group, Schizonepetae Spica in diaphoretic and antidote groups and Paeoniae Radix in neutralizer group might have reduced serum cholesterol level by reducing blood glucose level. From these results, composed crude drugs in 6 groups show various mechanisms in the action of BOF.

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“…BTS has been reported to inhibit atherosclerosis, 9) obesity, 10) hypertension 11) and hyperglycemia. 12) However, Three Kampo medicines, Boiogito (BOT), Bofutsushosan (BTS) and Orengedokuto (OGT), used for obese patients were investigated for their effects on adipogenesis in cultured rat white adipocytes.…”

Section: )mentioning

confidence: 99%

“…BTS has been reported to inhibit atherosclerosis, 9) obesity, 10) hypertension 11) and hyperglycemia. 12) However, pharmacological evidence for the anti-obesity effects of OGT and BOT remains obscure.…”

mentioning

confidence: 99%

The Kampo Medicines Orengedokuto, Bofutsushosan and Boiogito Have Different Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes: Comprehensive Analysis of Genetic Profiles

Yamakawa

Ishigaki

Takano

et al. 2008

Biological & Pharmaceutical Bulletin

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Metabolic syndrome, wherein patients have both diabetes mellitus and dyslipidemia, is reaching epidemic proportions due to dietary factors and sedentary lifestyles.1) A major cause of mortality in these patients is atherosclerotic macrovascular diseases, the majority of which result from dyslipidemia associated with insulin-resistant diabetes. Adipose tissues, which were once thought to function primarily as passive depots for storage of excess lipid, are now understood to play crucial roles in metabolic regulation, feeding behavior and secretion of a variety of metabolic hormones. 2,3)Excessive accumulation of adipose cells in obesity contributes to the development of metabolic and cardiovascular diseases, as well as certain cancers. 4,5) Adipocytes accumulate energy in the form of triacylglycerols, which can be hydrolyzed and released as glycerol plus free fatty acids. When energy intake is dominant, excess lipid storage in white adipose tissues can be established through an increase in the size of mature adipocytes and/or recruitment of preadipocytes. This situation may lead not only to obesity but also to related pathophysiological conditions, such as type 2 diabetes mellitus, since adipose tissues are not only insulin-responsive tissues that convert glucose into fat stores, but also endocrine organs participating in energy balance regulation.6,7) Adipogenesis has been extensively studied in vitro using murine preadipocyte lineages and rat white adipocytes. Adipose conversion from such fibroblastic precursors is divided into at least three steps, namely cell commitment, clonal amplification and phenotype expression. 8)The initial step involves the induction of expression of several adipose-specific genes, whereas later events result in the appearance of the functional characteristics of mature adipocytes, such as increased glucose transport capacity, through the expression of insulin-responsive glucose transporters, which represent a key step in lipogenesis, thereby leading to progressive lipid accumulation. As a key factor for controlling the adipose mass in adipocytes, examination of the inhibitory activities of substances on excess lipid storage in white adipocytes represents a rational strategy for preventing obesity.Orengedokuto (OGT), Bofutsushosan (BTS) and Boiogito (BOT) are well-known Japanese, Korean and Chinese traditional herbal medicines used to clinically prevent or improve obesity. BTS has been reported to inhibit atherosclerosis, 9) obesity, 10) hypertension 11) and hyperglycemia. 12) However, Three Kampo medicines, Boiogito (BOT), Bofutsushosan (BTS) and Orengedokuto (OGT), used for obese patients were investigated for their effects on adipogenesis in cultured rat white adipocytes. Administration of the three extracts suppressed adipogenesis in concentration-dependent manners (1-100 m mg/ml) without any cytotoxicity. Changes in mRNA expression levels were analyzed using a Rat 230 2.0 Affymetrix GeneChip® microarray system. DNA microarray analysis (total probe set: 31099) using cDNAs prepared...

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Bofutsushosan, a Traditional Chinese Formulation, Prevents Intimal Thickening and Vascular Smooth Muscle Cell Proliferation Induced by Balloon Endothelial Denudation in Rats

Cited by 14 publications

References 24 publications

Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

Effects of the oriental herbal medicine Bofu-tsusho-san in obesity hypertension: A multicenter, randomized, parallel-group controlled trial (ATH-D-14-01021.R2)

Effects of Single Administered Bofutsushosan-Composed Crude Drugs on Diabetic Serum Parameters in Streptozotocin-Induced Diabetic Mice

The Kampo Medicines Orengedokuto, Bofutsushosan and Boiogito Have Different Activities to Regulate Gene Expressions in Differentiated Rat White Adipocytes: Comprehensive Analysis of Genetic Profiles

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