Body weight and nonfatal myocardial infarction in a case-control study from Argentina

Abstract

The relationship between overweight and obesity and the risk of acute nonfatal myocardial infarction was analyzed, using data from a case-control study from Buenos Aires, Argentina. The study included 1000 patients with acute myocardial infarction and 1000 controls, who had been admitted to the same hospitals in which the cases had been identified, for acute conditions unrelated to known or potential risk factors for coronary heart disease. Only 32% of the cases and 41% of the controls had a Quetelet's index (body mass index, BMI, kg m-2) under 25% of the cases and 51% of the controls were overweight (BMI 25 to 30), and 15% of the cases and 8% of the controls severely obese (BMI > 30). After allowance for age and sex, the relative risks (RR) were 1.4 (95% confidence interval, CI, 1.1 to 1.7) for subjects with a body mass index of 25 to 30 and 2.2 (95% CI 1.7 to 3.1) for those with a body mass index more than 30. When additional adjustment was made for hypertension, diabetes, smoking and a family history of coronary heart disease, the RR was 1.2 (95% CI 1.0 to 1.6) among subjects with a body mass index of 25 to 30 and 1.7 (95% CI 1.3 to 2.4) for those with a body mass index more than 30. The trend in risk was significant. In the stratified analysis, the RR in younger people (30-44 years) with a body mass index more than 30 was 4.7 (95% CI 2.0 to 10.8), and the association was less strong in middle and older age.(ABSTRACT TRUNCATED AT 250 WORDS)

Systematic review/Meta-analysis The incidence of acute myocardial infarction in relation to overweight and obesity: a meta-analysis

“…We did not find proper articles by manual searching. Finally, 5 studies including 1 cohort study and 4 case-control studies were selected for further meta-analysis [9, 10, 12, 16, 17]. …”

“…Schargrodsky et al . demonstrated that overweight is an independent risk factor for MI [12]. The metabolic syndrome including abdominal obesity increased 2-fold in cardiovascular outcomes and 1.5-fold in all-cause mortality [28].…”

“…But the relation of overweight and obesity with AMI is still controversial. Overweight and obesity are associated with AMI in some studies [9–11] and another study also showed an independent relationship between them [12]. Besides, evidence whether overweight and obesity are risk factors for AMI is still inconsistent.…”

“…Five studies were selected for the meta-analysis. The area of the studies included Portugal, Spain, Italy, Argentina [9, 10, 12, 16, 17]. Besides, subgroup analysis was performed according to gender, geographical area and study type, and publication bias analysis was subsequently performed.…”

Obesity and Cardiometabolic Defects in Heart Failure Pathology

“…This showed that both overweight and obesity increased the risk of AMI (126). Obesity is considered to be an independent risk factor for MI analyzed, using data from a case study (104). Human studies have shown that the obesity is considered to be a metabolic syndrome which doubles the cardiovascular outcomes and mortality (86).…”