Body temperature cues as contextual stimuli: Modulation of hypothermia-induced retrograde amnesia

Mactutus, Charles F.; McCutcheon, Kevan; Riccio, David C.

doi:10.1016/0031-9384(80)90307-8

Cited by 19 publications

(15 citation statements)

References 56 publications

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“…Specifically, similar to many other features of the learning environment, temperature can act as a salient contextual cue, which, when reinstated, can support superior performance when compared with experiencing a change in thermal context. These data are also congruent with the enhanced performance that has been observed from reinstating a cold temperature with rodents (Mactutus et al, 1980) and humans (Oksa et al, 2006). This is the first study to demonstrate temperature-dependent performance with hot temperatures.…”

Section: Reinstating or Changing The Training Thermal Context At Testsupporting

confidence: 89%

“…With respect to the thermal context on learning, animal learning studies have been used to demonstrate that memory retrieval is dependent on the reinstatement of cold temperature states (Mactutus, McCutcheon, & Riccio, 1980;Mactutus & Riccio, 1978;Wetsel, Riccio, & Hinderliter, 1976), suggesting that temperature stimuli, similar to other sensory information, can be encoded along with task-specific information at the time of motor learning and subsequently act as a pertinent retrieval cue at the time of test. A natural extension then is that to optimize performance the training and test situations should have congruent thermal conditions (Clark & Jones, 1962;Oksa et al, 2006).…”

Section: Context-dependent Motor Behaviormentioning

confidence: 99%

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Temperature Dependency in Motor Skill Learning

Immink

Wright

Barnes

2012

Journal of Motor Behavior

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The present study investigated the role of temperature as a contextual condition for motor skill learning. Precision grip task training occurred while forearm cutaneous temperature was either heated (40-45 °C) or cooled (10-15 °C). At test, temperature was either reinstated or changed. Performance was comparable between training conditions while at test, temperature changes decreased accuracy, especially after hot training conditions. After cold training, temperature change deficits were only evident when concurrent force feedback was presented. These findings are the first evidence of localized temperature dependency in motor skill learning in humans. Results are not entirely accounted for by a context-dependent memory explanation and appear to represent an interaction of neuromuscular and sensory processes with the temperature present during training and test.

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Section: Reinstating or Changing The Training Thermal Context At Testsupporting

confidence: 89%

Section: Context-dependent Motor Behaviormentioning

confidence: 99%

Temperature Dependency in Motor Skill Learning

Immink

Wright

Barnes

2012

Journal of Motor Behavior

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“…Although it was assumed that the body temperature at the time of testing was the critical factor-that is, the appropriate cool cues were not available if the rat was allowed to rewarm to normal body temperature-perhaps the recovery from amnesia is simply time limited. We think the latter interpretation is unlikely, since in another study on recovery of a conditioned response, Mactutus, McCutcheon, and Riccio (1980) demonstrated that temperature, rather than time, was the critical variable. In their study, rats were exposed to warm water following a hypothermic reactivation treatment, in order to reverse the hypothermia.…”

Section: Discussionmentioning

confidence: 81%

Retrograde amnesia for extinction: Similarities with amnesia for original acquisition memories

Briggs

Riccio

2007

Learning & Behavior

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Two experiments were conducted using rats to determine whether extinction is susceptible to a traditional amnestic agent (i.e., hypothermia) and to examine whether amnesia for extinction follows the same characteristics as those that occur with original memories. In Experiment 1, rats received hypothermia immediately, 60 min, or 120 min after extinction. When tested, the subjects cooled shortly after extinction showed little memory of the extinction training. This amnesia for extinction disappeared with longer postextinction delays, demonstrating a temporal gradient. Experiment 2 replicated the basic finding and demonstrated that an amnestic-extinguished memory could be recovered by reexposing the subjects to the amnestic agent and that the recovered extinction memory did not persist. These findings provide more evidence that extinction is a form of new learning and are consistent with retrograde amnesia research for original memories showing a temporal gradient and alleviation of retrograde amnesia by reexposure to the amnestic agent.

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“…A likely explanation of these results is that exogenous administration of ACTH shortly prior to test maximizes the similarity of internal states present at training and testing. As the resemblance of training and testing sessions increases, the probability of retrieving information acquired during the training session also increases (d. Mactutus, McCutcheon, & Riccio, 1980;Quartermain & Judge, 1983;Richardson, Guanowsky, Ahlers, & Riccio, 1984;Spear, 1973Spear, , 1978. If this is, indeed, the mechanism by which the findings of the first two experiments can bebest explained, then delaying the test for some period after administration of ACTH should reduce or eliminate the recovery of the extinguished memory.…”

Section: Methodsmentioning

confidence: 99%

ACTH-induced recovery of extinguished avoidance responding

1984

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In addition to prolonging the resistance to extinction of aversively motivated behavior, administration of ACTH at' testing has been shown to alleviate retention deficits associated with several types of paradigms (e.g., retrograde amnesia, Kamin effect). To determine whether comparable recovery could be induced by ACTH with respect to a previously extinguished avoidance response, four experiments using rats were conducted. In each, decrements in avoidance responding produced by extinction were alleviated by exogenous ACTH. For three reasons, the observed effects of ACTH on rats' avoidance behavior were judged to be on memory processes rather than simply an alteration in motor behavior. First, pretest administration of ACTH was effective in alleviating performance deficits after extinction in both active (Experiment 1) and passive (Experiments 2-4) avoidance tasks. Second, administration of ACTH had no effect on the behavior of shocked, but untrained, subjects (Experiment 3). Finally, the ACTH-induced recovery was relatively durable in that it persisted for at least 24 h (Experiments 3-4).This durability of the ACTH-induced recovery of avoidance was unexpected in terms of an interpretation emphasizing the state-dependent nature of the present paradigm. The data extend previous findings and are discussed in relation to other research on memory recovery.

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Body temperature cues as contextual stimuli: Modulation of hypothermia-induced retrograde amnesia

Cited by 19 publications

References 56 publications

Temperature Dependency in Motor Skill Learning

Temperature Dependency in Motor Skill Learning

Retrograde amnesia for extinction: Similarities with amnesia for original acquisition memories

ACTH-induced recovery of extinguished avoidance responding

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