Body Temperature Circadian Rhythm Variability Corresponds to Left Ventricular Systolic Dysfunction in Decompensated Cardiomyopathic Hamsters

Ahmed, Amany; Gondi, Sreedevi; Cox, Casey; Zheng, Minjuan; Mohammed, Anwarullah; Stupin, Igor; Wang, Suwei; Vela, Deborah; Brewer, Alan; Elayda, MacArthur A.; Buja, L. Maximilian; Casscells, S. Ward; Wilson, James M.

doi:10.1016/j.cardfail.2011.07.004

Cited by 2 publications

(2 citation statements)

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“…PPA is a classical nonlinear analytical method that can analyze the variability of time series signals. The few studies that have applied fast Fourier or cosinor analysis suggest that variability in BT can be implicated for the diagnosis of cardiovascular disorders [ 18 ]. Poincaré plot indices have advantages because the data have no requirements for normal distribution or special processing that spectral analysis requires, but it provides a lot of information, especially if the position of the points relative to the line of identity is taken into consideration [ 14 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

“…This time-domain analysis can determine short- and long-term variabilities and asymmetry in the variabilities. While the variabilities in BT have also been investigated in a few studies, no PPA has been performed yet for this parameter [ 18 ]. The further goal was to reveal the circadian rhythm of these Poincaré parameters in control animals and to disclose the potential disturbances in these factors of the new substrain.…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Motor Activity and Thermoregulation in a Schizophrenia Rat Model for Translational Science

et al. 2015

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BackgroundSchizophrenia is accompanied by altered motor activity and abnormal thermoregulation; therefore, the presence of these symptoms can enhance the face validity of a schizophrenia animal model. The goal was to characterize these parameters in freely moving condition of a new substrain of rats showing several schizophrenia-related alterations.MethodsMale Wistar rats were used: the new substrain housed individually (for four weeks) and treated subchronically with ketamine, and naive animals without any manipulations. Adult animals were implanted with E-Mitter transponders intraabdominally to record body temperature and locomotor activity continuously. The circadian rhythm of these parameters and the acute effects of changes in light conditions were analyzed under undisturbed circumstances, and the effects of different interventions (handling, bed changing or intraperitoneal vehicle injection) were also determined.ResultsDecreased motor activity with fragmented pattern was observed in the new substrain. However, these animals had higher body temperature during the active phase, and they showed wider range of its alterations, too. The changes in light conditions and different interventions produced blunted hyperactivity and altered body temperature responses in the new substrain. Poincaré plot analysis of body temperature revealed enhanced short- and long-term variabilities during the active phase compared to the inactive phase in both groups. Furthermore, the new substrain showed increased short- and long-term variabilities with lower degree of asymmetry suggesting autonomic dysregulation.ConclusionsIn summary, the new substrain with schizophrenia-related phenomena showed disturbed motor activity and thermoregulation suggesting that these objectively determined parameters can be biomarkers in translational research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%