Body size and composition, physical activity and sedentary time in relation to endogenous hormones in premenopausal and postmenopausal women: Findings from the <scp>UK</scp> Biobank

Tin, Sandar Tin; Reeves, Gillian; Key, Timothy J.

doi:10.1002/ijc.33010

Cited by 25 publications

(30 citation statements)

References 46 publications

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“…Although there were statistically significant associations between measured, self-reported physical activity and sedentary time and IGF-I concentrations, the magnitudes of the associations were small (generally ~ 1% in the highest group in comparison with the lowest), suggesting that higher physical activity is unlikely to have a meaningful impact on cancer risk mediated by IGF-I. The magnitudes of these associations are largely consistent with other cross-sectional analyses [11,22,39], while results from clinical trials have been inconclusive [15][16][17]40].…”

Section: Discussionsupporting

confidence: 83%

“…The primary model was also further adjusted for BMI (categories as above). Adjustment covariates were defined a priori based on previous analyses of UK Biobank data [22,38], and categories were used to account for nonlinear associations.…”

Section: Discussionmentioning

confidence: 99%

“…In this paper, we aimed to examine the associations of objectively measured and self-reported physical activity and sedentary time, as well as anthropometric factors, with serum concentrations of IGF-I, SHBG, and total and free testosterone in a cohort of 117,100 men; we recently reported similar analyses in women [22]. As adiposity may be important in the associations between physical activity and hormones, we first describe the associations of BMI with the hormones, and then the associations of physical activity with the hormones both without and with adjustment for BMI.…”

Section: Introductionmentioning

confidence: 99%

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Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank

Watts

Pérez-Cornago

Allen

et al. 2021

Cancer Causes Control

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Purpose Physical activity may reduce the risk of some types of cancer in men. Biological mechanisms may involve changes in hormone concentrations; however, this relationship is not well established. Therefore, we aimed to investigate the associations of physical activity with circulating insulin-like growth factor-I (IGF-I), sex hormone-binding globulin (SHBG, which modifies sex hormone activity), and total and free testosterone concentrations, and the extent these associations might be mediated by body mass index (BMI). Methods Circulating concentrations of these hormones and anthropometric measurements and self-reported physical activity data were available for 117,100 healthy male UK Biobank participants at recruitment. Objectively measured accelerometer physical activity levels were also collected on average 5.7 years after recruitment in 28,000 men. Geometric means of hormone concentrations were estimated using multivariable-adjusted analysis of variance, with and without adjustment for BMI. Results The associations between physical activity and hormones were modest and similar for objectively measured (accelerometer) and self-reported physical activity. Compared to men with the lowest objectively measured physical activity, men with high physical activity levels had 14% and 8% higher concentrations of SHBG and total testosterone, respectively, and these differences were attenuated to 6% and 3% following adjustment for BMI. Conclusion Our results suggest that the associations of physical activity with the hormones investigated are, at most, modest; and following adjustment for BMI, the small associations with SHBG and total testosterone were largely attenuated. Therefore, it is unlikely that changes in these circulating hormones explain the associations of physical activity with risk of cancer either independently or via BMI.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank

Watts

Pérez-Cornago

Allen

et al. 2021

Cancer Causes Control

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“…Despite this, we were able to show a robust association between physical activity and protection from liver disease and its progression. Notably, multiple well performed studies used the same approach with the UKB [30][31][32][33] and saw a similar performance as other case-control studies.…”

Section: Implications For Patient Counsellingmentioning

confidence: 75%

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Schneider¹,

Zandvakili²,

Thaiss³

et al. 2021

JHEP Reports

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Many of these factors including age, education, smoking, alcohol consumption and body mass index have also been associated with hormone concentrations although the associations of hormones with other factors such as parity and age at first birth appear to be modest. [27][28][29] However, adjustment for all these factors including body mass index had minimal impact on the associations of hormones and SHBG with breast cancer risk (as shown in Table 2). Moreover, mutual adjustment for hormones did not substantially affect the associations.…”

Section: Effects Of Potential Confoundersmentioning

confidence: 99%

Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank

2021

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Background Some endogenous hormones have been associated with breast cancer risk, but the nature of these relationships is not fully understood. Methods UK Biobank was used. Hormone concentrations were measured in serum collected in 2006–2010, and in a repeat subsample (N ~ 5000) in 2012–13. Incident cancers were identified through data linkage. Cox regression models were used, and hazard ratios (HRs) corrected for regression dilution bias. Results Among 30,565 pre-menopausal and 133,294 post-menopausal women, 527 and 2,997, respectively, were diagnosed with invasive breast cancer during a median follow-up of 7.1 years. Cancer risk was positively associated with testosterone in post-menopausal women (HR per 0.5 nmol/L increment: 1.18; 95% CI: 1.14, 1.23) but not in pre-menopausal women (pheterogeneity = 0.03), and with IGF-1 (insulin-like growth factor-1) (HR per 5 nmol/L increment: 1.18; 1.02, 1.35 (pre-menopausal) and 1.07; 1.01, 1.12 (post-menopausal); pheterogeneity = 0.2), and inversely associated with SHBG (sex hormone-binding globulin) (HR per 30 nmol/L increment: 0.96; 0.79, 1.15 (pre-menopausal) and 0.89; 0.84, 0.94 (post-menopausal); pheterogeneity = 0.4). Oestradiol, assessed only in pre-menopausal women, was not associated with risk, but there were study limitations for this hormone. Conclusions This study confirms associations of testosterone, IGF-1 and SHBG with breast cancer risk, with heterogeneity by menopausal status for testosterone.

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Body size and composition, physical activity and sedentary time in relation to endogenous hormones in premenopausal and postmenopausal women: Findings from the UK Biobank

Cited by 25 publications

References 46 publications

Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank

Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank

Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Endogenous hormones and risk of invasive breast cancer in pre- and post-menopausal women: findings from the UK Biobank

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