Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Schneider, Carolin V.; Zandvakili, Inuk; Thaiss, Christoph A.; Schneider, Kai Markus

doi:10.1016/j.jhepr.2021.100263

Cited by 44 publications

(49 citation statements)

References 35 publications

(43 reference statements)

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“…LPA, light-intensity physical activity; MVPA, moderate-to vigorous-intensity physical activity; NAFLD, non-alcoholic fatty liver disease; SB, sedentary behaviour preventive effect on incident NAFLD 13 and progression to severe liver disease and mortality in patients with liver disease. 13,43 These studies were conducted in western counties and further prospective studies from Asian countries are required. Second, because alcohol consumption was calculated by a self-administered questionnaire, there could be reporting bias including underevaluation.…”

Section: Ta B L Ementioning

confidence: 99%

“…In recent years, the health benefits of light-intensity PA (LPA, ≤2.9 METs) 8,9 and overall MVPA, including sporadic MVPA, 10,11 have been shown. Although a few studies [12][13][14] confirmed the association between accelerometer-measured overall PA and NAFLD, no studies assessed the differences in dose-response associations by PA intensity. Additionally, some of these studies were limited by small sample size 14 and indirect assessment of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] none of those studies examined the continuous dose-response relationship. This study found for the first time that PA (TPA and MVPA) was associated with NAFLD in a curvilinear dose-response relationship, liver disease, systolic blood pressure, total cholesterol, fasting plasma glucose, anti-hypertensive medication use, lipid medication use, diabetic medication use, plus covariates in model 1.…”

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confidence: 99%

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Dose–response relationships of accelerometer‐measured sedentary behaviour and physical activity with non‐alcoholic fatty liver disease

Tsunoda

Kitano

Kitagawa

et al. 2021

Aliment Pharmacol Ther

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Background: Although a few studies have confirmed the association of accelerometermeasured sedentary behaviour (SB) and physical activity (PA) with non-alcoholic fatty liver disease (NAFLD), PA intensity and co-dependent daily time-use of movement behaviours are yet to be studied. Aims:To cross-sectionally examine the dose-response relationship between accelerometer-measured SB or PA and NAFLD using cubic spline analysis and the interdependence of movement behaviours over 24 hours with compositional data analysis.Methods: Data were obtained between May 2017 and February 2020 from 1914 people who were not heavy alcohol drinkers using health check-ups at the Meiji Yasuda Shinjuku Medical Center, Tokyo. SB, light-intensity PA (LPA) and moderateto vigorous-intensity PA (MVPA) were evaluated using a triaxial accelerometer. Fatty liver was diagnosed by ultrasonography.Results: A multivariable-adjusted logistic model showed an inverse association between MVPA and NAFLD (odds ratio [OR] per 600 metabolic equivalents [MET]min/week = 0.85, 95% confidence interval [CI] = 0.76-0.96). MVPA showed rapidly decreasing odds of NAFLD to approximately 1800 MET-min/week in cubic spline analysis and then a moderate decline. Although SB was significantly associated with NAFLD in a body mass index (BMI)-unadjusted model, it was not significant in a BMI-adjusted model. In the compositional isotemporal substitution, reallocating 60 min/day of SB to MVPA decreased the odds of NAFLD by 22% (OR = 0.78, 95% CI: 0.65-0.93), whereas reallocating 60 min/day of MVPA to SB increased it by 69% (OR = 1.69, 95% CI: 1.12-2.38). Conclusions:The inverse dose-response association between MVPA and NAFLD confirms increased MVPA as a target for the prevention of NAFLD.

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Section: Ta B L Ementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Dose–response relationships of accelerometer‐measured sedentary behaviour and physical activity with non‐alcoholic fatty liver disease

Tsunoda

Kitano

Kitagawa

et al. 2021

Aliment Pharmacol Ther

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“…The ICD codes for cardiovascular disease (CVD) were defined from Lees et al 9 and Tavaglione et al 10 , and self-reported codes used were "angina","heart attack/myocardial infraction", "stroke", "subarachnoid haemorrhage", "brain haemorrhage", "ischaemic stroke" and "heart failure/pulmonary odema". The ICD codes for liver disease were taken from Schneider et al 11 and the self-reported codes used were "liver failure/cirrhosis", "infective/viral hepatitis", "alcoholic liver disease/alcoholic cirrhosis" and "liver/biliary/pancreas problem". The codes for kidney disease were taken from Lin et al 12 and Definitions of End Stage Renal Disease for UK Biobank Phase 1 Outcomes Adjudication (biobank.ndph.ox.ac.uk/ukb/ukb/docs/alg_outcome_esrd.pdf).…”

Section: Disease/physiological Condition Categoriesmentioning

confidence: 99%

Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts

Whitcher

Thanaj

Cule

et al. 2021

Preprint

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Longitudinal studies provide unique insights into the impact of environmental factors and lifespan issues on health and disease. Here we investigate changes in body composition in 3,088 free-living participants, part of the UK Biobank in-depth imaging study. All participants underwent neck-to-knee MRI scans at baseline and after approximately two years (re-imaging). Image-derived phenotypes for each participant were extracted using a fully-automated image processing pipeline, including volumes of several tissues and organs: liver, pancreas, spleen, kidneys, total skeletal muscle, iliopsoas muscle, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (ASAT), as well as fat and iron content in liver, pancreas and spleen. Overall, no significant changes were observed in BMI, body weight, or waist circumference over the scanning interval, despite some large individual changes. A significant decrease in grip strength was observed, coupled to small, but statistically significant, decrease in all skeletal muscle measurements. Significant increases in VAT and intermuscular fat in the thighs were also detected in the absence of changes in BMI, waist circumference and ectopic-fat deposition. Adjusting for disease status at baseline did not have an additional impact on the changes observed. In summary, we show that even after a relatively short period of time significant changes in body composition can take place, probably reflecting the obesogenic environment currently inhabited by most of the general population in the United Kingdom.

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“…Treatment options for HCC can be broadly classified into surgical resection and nonsurgical therapies dependent upon the stage of the disease, liver function, availability of donor organs, cost of treatment, and so on [128]. The Westernized diet and sedentary lifestyle promote the progression of NAFLD [129,130]. A cohort study in Europe also showed that physical activity is inversely associated with the risk of HCC [131].…”

Section: Treatment Options Against Hccmentioning

confidence: 99%

The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma

Zhang

Yang

2021

Cancers

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Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, followed by cholangiocarcinoma (CCA). HCC is the third most common cause of cancer death worldwide, and its incidence is rising, associated with an increased prevalence of obesity and nonalcoholic fatty liver disease (NAFLD). However, current treatment options are limited. Genetic factors and epigenetic factors, influenced by age and environment, significantly impact the initiation and progression of NAFLD-related HCC. In addition, both transcriptional factors and post-transcriptional modification are critically important for the development of HCC in the fatty liver under inflammatory and fibrotic conditions. The early diagnosis of liver cancer predicts curative treatment and longer survival. However, clinical HCC cases are commonly found in a very late stage due to the asymptomatic nature of the early stage of NAFLD-related HCC. The development of diagnostic methods and novel biomarkers, as well as the combined evaluation algorithm and artificial intelligence, support the early and precise diagnosis of NAFLD-related HCC, and timely monitoring during its progression. Treatment options for HCC and NAFLD-related HCC include immunotherapy, CAR T cell therapy, peptide treatment, bariatric surgery, anti-fibrotic treatment, and so on. Overall, the incidence of NAFLD-related HCC is increasing, and a better understanding of the underlying mechanism implicated in the progression of NAFLD-related HCC is essential for improving treatment and prognosis.

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Physical activity is associated with reduced risk of liver disease in the prospective UK Biobank cohort

Cited by 44 publications

References 35 publications

Dose–response relationships of accelerometer‐measured sedentary behaviour and physical activity with non‐alcoholic fatty liver disease

Dose–response relationships of accelerometer‐measured sedentary behaviour and physical activity with non‐alcoholic fatty liver disease

Precision MRI Phenotyping Enables Detection of Small Changes in Body Composition for Longitudinal Cohorts

The Emerging Factors and Treatment Options for NAFLD-Related Hepatocellular Carcinoma

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