Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma

Ciprandi, Giorgio; Pistorio, Angela; Tosca, Mariangela; Ferraro, Maria; Cirillo, Ignazio

doi:10.1016/j.rmed.2008.08.008

Cited by 47 publications

(40 citation statements)

References 31 publications

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“…Only one study by Ciprandi et al 9 reported a significant association between increased BMI and AR in males. This finding is conflicting with previous studies and with our study.…”

Section: Discussionmentioning

confidence: 99%

“…studies have reported positive associations between increased BMI and AR. [9][10][11] Nevertheless, the mechanism for the association between respiratory allergic diseases and obesity and the reasons for the apparent difference between men and women remain unclear. 2 Because both respiratory allergic diseases and obesity are characterized by inflammation, a common inflammatory pathway has been proposed as a plausible explanation for the association between respiratory allergy and obesity.…”

Section: Introductionmentioning

confidence: 99%

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A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

Bist¹,

Bhagat²,

Kala³

2016

An International Journal Clinical Rhinology

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Objectives: Although the association between obesity and bronchial asthma (BA) has been gaining more attention, few studies have been conducted concerning the relationship between body mass index (BMI) and other allergic diseases. The purpose of this study is to determine the relationship between allergic rhinitis (AR) and BMI. Materials and methods:This was a retrospective study. Two hundred and ten patients of AR (138 males and 72 females) and 424 healthy controls were included in the study. The BMI of patients and controls were calculated and correlated. Results:The percentage of AR patients with a low BMI was 9.5%, whereas 57.6% had a normal BMI; 21% were preobese and 9.5% were obese. In the control group, 48.6% subjects had normal BMI range followed by preobese 21.2%, underweight 20.3%, and obese 9.9%. Among the overweight (preobese + obese) category, the maximum number of subjects belonged to cases, i.e., 32.8% with an odds ratio (OR) of 0.95 (95% confidence interval (CI) 0.91-1.07). Thus, AR was not associated with high BMI. Among the underweight, the maximum number of subjects belonged to the control group, i.e., 20.3% with an OR of 2.13 (95% CI 1.24-3.68). Thus, AR had no relationship with lower BMI also. It was also observed that more of the female patients (18, 29.1, and 12.5% were underweight, preobese, and obese respectively) had deranged BMI than male patients (5.3, 20.2, and 7.9% were underweight, preobese, and obese respectively). A relative risk of 1.124 (95% CI 1.01-1.23) and 1.04 (95% CI 0.95-1.13) was present in female patients with low and high BMI respectively, which is statistically significant (p = 0.0008). Conclusion:It was concluded that BMI was not associated with increased prevalence of AR. Among the underweight and overweight, AR was more common in females than in males. Thus, BMI had a significant association with AR among female patients. Overall, BMI had no significant association with AR.

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“…Only one study by Ciprandi et al 9 reported a significant association between increased BMI and AR in males. This finding is conflicting with previous studies and with our study.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

Bist¹,

Bhagat²,

Kala³

2016

An International Journal Clinical Rhinology

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“…La influencia del IMC sobre las variables funcionales pulmonares de nuestros pacientes es más difícil de explicar. Un estudio reciente 23 provee la evidencia de una significativa correlación entre el IMC y la rinitis alérgica e hiperreactividad bronquial, pero ningún impacto en los parámetros funcionales demostrados en la espirometría. Aunque las evidencias no son unánimes, 24,25 los índices de masa corporal indicadores de obesidad pueden afectar la función respiratoria, con reducción del volumen y la capacidad pulmonar en ausencia de enfermedad respiratoria, y pueden exagerar ese efecto en una enfermedad de la vía aérea preexistente.…”

Section: Discussionunclassified

Análisis de la curva flujo-volumen en niños y adolescentes con rinitis alérgica sin asma

et al. 2013

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Análisis de la curva flujo-volumen en niños y adolescentes con rinitis alérgica sin asmaAnalysis of the flow-volume curve in children and adolescents with allergic rhinitis without asthma RESUMEN Introducción. Existen evidencias epidemiológicas, funcionales y patológicas que vinculan las vías aéreas superior e inferior, reconocidas clínicamente como una vía aérea única. Los pacientes con rinitis alérgica sin asma podrían presentar anormalidades espirométricas subclínicas. Objetivos. Describir los resultados de las curvas flujo-volumen en un grupo de pacientes con rinitis alérgica sin asma y analizar las posibles asociaciones entre las variables antropométricas, clínicas y bioquímicas con los resultados anormales de las pruebas espirométricas. Población y métodos. Estudio observacional descriptivo, en el que se incluyeron niños y adolescentes de entre 6 y 18 años con síntomas de rinitis alérgica sin asma. Se estableció la edad, el sexo, el índice de masa corporal y la duración de la rinitis por la historia clínica. Se realizaron pruebas cutáneas con alérgenos, espirometría por curva flujo-volumen, determinación de eosinófilos en la sangre y la secreción nasal, e IgE sérica total. Resultados. Se estudiaron 84 pacientes; 21 (25%; IC 95% 15,1 a 34,8) presentaron alguna variable espirométrica alterada. El índice FEV1/FVC fue el más afectado (10/84; 12% IC 95% 4,3 a 19,4). El análisis de regresión logística múltiple determinó que la alteración espirométrica se asoció con el número de eosinófilos en la sangre (OR 1,00229; IC 95% 1,00022 a 1,00436; p= 0,03) y el índice de masa corporal (OR 1,31282; IC 95% 1,08611 a 1,58685; p= 0,0049). Conclusiones. Los resultados muestran la presencia de alteraciones espirométricas en un importante porcentaje de niños y adolescentes con rinitis alérgica sin asma. El recuento absoluto de eosinófilos en la sangre y el índice de masa corporal estarían asociados a la alteración subclínica de la función pulmonar. Conflicto de intereses:Ninguno que declarar.Recibido: 22-10-201222-10- Aceptado: 12-3-2013 sobre Asma y Alergia en la Infancia (ISAAC), en su fase III, mostró una prevalencia para la Argentina de 20,6% en el grupo etario de 6 a 7 años, y de 34,9% en el de 13 a 14 años. 1 La relación entre la rinitis y el asma se ha establecido mediante evidencias epidemiológicas, clínicas, funcionales y terapéuticas.2 Estas enfermedades tienen un nexo fisiopatológico frecuente con la atopia y existen evidencias de que la inflamación mediada por eosinófilos está implicada en la patogenia de ambas.3 Esto ha llevado al concepto holístico de una misma enfermedad por compromiso de una vía aérea única. 3,4 Un alto porcentaje de los niños con rinitis alérgica sin asma manifiestan h i p e r r e a c t i v i d a d b r o n q u i a l a la metacolina, la histamina y el ejercicio, 4-6 lo que podría significar un aumento del riesgo para la aparición del asma. 4 Recientemente, se han demostrado alteraciones subclínicas en la función pulmonar de adultos 7 y niños 8,9 con rinitis alérgica sin asma, con reactivida...

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“…As age is not considered in school the presence or absence of AR in girls and boys regarding BMI distribution (Table 1). There are three studies in the literature which investigates the effect of high BMI values studies carried out by Ciprandi et al [18] and by us are based on clinical data and specialist diagnoses and posses a stronger base.…”

Section: Discussionmentioning

confidence: 99%

“…In another study carried out by Kilpeläinen et al [1] it was reported that high BMI values in women was the reason of increase in AR risk and did not effect males at all. In a study carried out by Ciprandi et al [18] a global relationship was determined between BMI values and AR and asthma.…”

Section: Discussionmentioning

confidence: 99%

The effects of allergic rhinitis on growth, development and body mass indexes in school children

Paksoy¹,

Eken²,

Aydın³

et al. 2010

Indian J Otolaryngol Head Neck Surg

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Objective The purpose of this study is to determine the frequency of allergic rhinitis (AR) in children and investigate if allergenic rhinitis demonstrated any effects on developmental growth levels and body mass indexes (BMI) in children.Materials and methods 651 students, between 3-15 years of age who were randomly selected from four elementary schools located at Kartal, Istanbul were assessed according to symptoms and the presence of AR by nasal examination with the aid of a 0 degree 2.7 mm hand rigid endoscope. Height and weight percentile values of students regarding growth according to age and their BMI were calculated and statically assessed. Results obtained are presented. Conclusion AR prevalence was higher in girls independently from BMI values. We determined a strong relationship between BMI values and AR dependant to age and gender. Results

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Body mass index, respiratory function and bronchial hyperreactivity in allergic rhinitis and asthma

Abstract: This study provides the first evidence of a significant relationship between BMI and allergic rhinitis and between BMI and BHR in both allergic disorders.

Cited by 47 publications

References 31 publications

A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

A Clinical Study of Relationship of Body Mass Index with Allergic Rhinitis

Análisis de la curva flujo-volumen en niños y adolescentes con rinitis alérgica sin asma

The effects of allergic rhinitis on growth, development and body mass indexes in school children

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