Body mass index, lifestyles, physical performance and cognitive decline: The “Treviso Longeva (Trelong)” study

Gallucci, Maurizio; Mazzuco, Stefano; Ongaro, Fausta; Giorgi, Enrico Di; Mecocci, Patrizia; Cesari, Matteo; Albani, Diego; Forloni, Gianluigi; Durante, Elisabetta; Gajo, Giovanni Battista; Zanardo, Andrea; Siculi, Marinella; Caberlotto, Livio; Regini, C.

doi:10.1007/s12603-012-0397-1

Cited by 57 publications

(52 citation statements)

References 92 publications

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“…Nine of the 34 articles examined the association between HGS at baseline and cognition at follow up . The follow‐up periods ranged from 3.6 to 7 years .…”

Section: Resultsmentioning

confidence: 99%

“…Most studies used a Jamar Hand Dynamometer (n = 14). 23,26,28,30,[32][33][34]36,38,41,43,49,64,69 Other dynamometers used were from Smedley (n = 2), 62,68 Takai (n = 2), 48,61 Bruel-Kjaer (n = 1), 67 Chatillon 100 (n = 1), 66 Creative Health Products (n = 1), 65 Collins (n = 1), 29 Lafayette (n = 1), 60 Martin (n = 1), 44 Nicholas (n = 1), 40 Rolyan (n = 1) 37 and eight articles 31,35,39,42,[45][46][47]63 did not mention which dynamometer was used. The hand that was used to measure HGS varied as well.…”

Section: Selection and Quality Assessmentmentioning

confidence: 99%

“…30,31,35,36,[38][39][40][41][42]44,46,47,61,62,64 Other studies used the non-dominant hand (n = 2), 26,69 the right hand (n = 1) 37 or both hands and reported the mean values (n = 9) 28,32,33,43,45,48,49,60,68 or the stronger hand (n = 2). 29,67 The follow-up period ranged from 9 months to 33 years.…”

Section: Selection and Quality Assessmentmentioning

confidence: 99%

“…Nine of the 34 articles examined the association between HGS at baseline and cognition at follow up. 23,[28][29][30][31][32][33][34][35] The follow-up periods ranged from 3.6 32 to 7 years. 29 Four studies used the Mini-Mental State Examination (MMSE) and one article used the Modified Mini-Mental State Examination (3MS) as an outcome measurement, 23,[28][29][30][31] whereas four studies used a formal diagnosis of Alzheimer's disease (clinical or postmortem) or any other diagnosis of dementia.…”

Section: Hgs and Cognitionmentioning

confidence: 99%

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Prognostic value of handgrip strength in people aged 60 years and older: A systematic review and meta‐analysis

Rijk

Roos

Deckx

et al. 2015

Geriatrics Gerontology Int

290

212

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“…Nine of the 34 articles examined the association between HGS at baseline and cognition at follow up . The follow‐up periods ranged from 3.6 to 7 years .…”

Section: Resultsmentioning

confidence: 99%

Section: Selection and Quality Assessmentmentioning

confidence: 99%

Section: Selection and Quality Assessmentmentioning

confidence: 99%

Section: Hgs and Cognitionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic value of handgrip strength in people aged 60 years and older: A systematic review and meta‐analysis

Rijk

Roos

Deckx

et al. 2015

Geriatrics Gerontology Int

290

212

View full text Add to dashboard Cite

show abstract

“…Handgrip strength is a reliable surrogate for whole-body muscle strength [15], including of the lower extremities [16], and previous studies have reported that decreases in handgrip strength are associated with increased mortality [17], mobility declines [18], functional disability [19], and cognitive deterioration [20] in the elderly.…”

Section: Introductionmentioning

confidence: 99%

Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

et al. 2016

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BackgroundDecreased muscle strength can lead to adverse health outcomes in the elderly. A potential association between phthalate exposure and muscle strength was suggested previously, but has not been investigated directly. We hypothesized that phthalate exposure is associated with lower handgrip strength and that the association is modified by the dietary omega-6 to omega-3 ratio.MethodsWe analyzed 1,228 participants (≥60 years of age) recruited in Seoul and Asan, Republic of Korea. The study participants were surveyed up to three times between 2012 and 2015. At every survey, we collected urine samples and measured handgrip strength twice for each hand. The associations between urine phthalate metabolite concentrations and handgrip strength were evaluated using linear mixed models. Based on dietary information from 391 individuals who participated in the first survey in Seoul, we evaluated the heterogeneity of the association for those with high and low omega-6 to omega-3 ratios, using 8.81 (the 75th quantile) as a cutoff value.ResultsLog-transformed creatinine-adjusted concentrations of mono-(2-ethyl-5-oxohexyl phthalate (MEOHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), and mono-n-butyl phthalate (MnBP) were inversely associated with all measured handgrip strengths (β = −0.69 to −0.42, all p-values < 0.05). Associations between phthalate biomarkers and handgrip strength did not differ by sex. When the dietary subgroup was stratified by the omega-6 to omega-3 ratio, the associations were stronger among participants with high ratios.ConclusionsWe found inverse associations between phthalate biomarkers and handgrip strength in the elderly; this association was modified by the dietary omega-6 to omega-3 ratio.Electronic supplementary materialThe online version of this article (doi:10.1186/s12940-016-0176-2) contains supplementary material, which is available to authorized users.

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Cardiovascular risk factors and APOE‐ε4 status affect memory functioning in aging via changes to temporal stem diffusion

McKinnon

Stickel

Ryan

2020

J of Neuroscience Research

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Prior research investigating associations between hypertension, obesity, and apolipoprotein (APOE) genotype status with memory performance among older adults has yielded inconsistent results. This may reflect, in part, a lack of first accounting for the effects these variables have on structural brain changes, that in turn contribute to age-related memory impairment. The current study sought to clarify the relationships between these factors via path modeling. We hypothesized that higher body mass index (BMI), hypertension, and being an APOE-ε4 allele carrier would predict poorer memory scores, with much of these effects accounted for by indirect effects operating via differences in the integrity of temporal stem white matter. Participants included 125 healthy older adults who underwent neuropsychological assessment and diffusion-weighted MRI scanning. Direct effects were found for hypertension and demographic variables including age, sex, and education. Importantly, indirect effects were found for BMI, hypertension, APOE-ε4 status, age, and sex, where these factors predicted memory scores via their impact on temporal stem diffusion measures. There was also a dual effect of sex, with a direct effect indicating that females had better memory performance overall, and an indirect effect indicating that females with greater temporal stem diffusion had poorer memory performance. Results suggest that changes to the integrity of temporal white matter in aging may underpin reduced memory performance. These results highlight that accounting for variables that not only directly impact cognition, but also for those that indirectly impact cognition via structural brain changes, is crucial for understanding the impact of risk factors on cognition.

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Body mass index, lifestyles, physical performance and cognitive decline: The “Treviso Longeva (Trelong)” study

Cited by 57 publications

References 92 publications

Prognostic value of handgrip strength in people aged 60 years and older: A systematic review and meta‐analysis

Prognostic value of handgrip strength in people aged 60 years and older: A systematic review and meta‐analysis

Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Cardiovascular risk factors and APOE‐ε4 status affect memory functioning in aging via changes to temporal stem diffusion

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