Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Kim, Kyoung Nam; Lee, Mee Ri; Choi, Yoon-Hyeong; Hwang, Han Jeong; Oh, Se Young; Park, Choong-Hee; Hong, Yun Chul

doi:10.1186/s12940-016-0176-2

Cited by 15 publications

(13 citation statements)

References 49 publications

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“…Two primary exposure variables were used in this study: handgrip strength and BMI from the first wave. Handgrip strength was measured by using a dynamometer (Model number: NO6103, Manufacturer: TANITA, Japan), which measures handgrip strength in units of 0.1 kgF and has been used in multiple previous studies that determined handgrip strength [ 18 , 19 ]. Upon measurement, the participant was in a seated or standing position, her elbow at a right angle, and the wrist in neutral position.…”

Section: Methodsmentioning

confidence: 99%

Association among handgrip strength, body mass index and decline in cognitive function among the elderly women

Jeong¹,

Choi²,

Kim

et al. 2018

BMC Geriatr

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BackgroundThe association between handgrip strength combined with body mass index (BMI) and cognitive impairment has not been thoroughly examined. We aimed to investigate whether the relationship between handgrip strength and risk of cognitive impairment is altered by the presence of obesity in older women.MethodsA total of 544 older women aged over 65 years without cognitive impairment from the Korean Longitudinal Study of Aging (KLoSA) were included in the study. Handgrip strength was classified in a binary manner (weak or strong) or in tertiles and obesity was defined as a BMI ≥ 25 kg/m2, in accordance with the Asia-Pacific World Health Organization criteria. Incident cognitive impairment was defined as a Korean Mini-mental State Examination (K-MMSE) score of less than 24 after eight years of follow-up.ResultsStrong handgrip strength was associated with reduced likelihood of developing cognitive impairment compared to weak handgrip strength in obese women (adjusted odds ratio, aOR 0.23, 95% confidence interval, CI 0.08–0.66). The highest tertile of handgrip strength was associated with reduced risk of incident cognitive impairment (aOR 0.16, 95% CI 0.04–0.70), compared to the lowest tertile of handgrip strength in obese women, with a significant linear trend (p for trend = 0.016). Furthermore, the highest tertile of handgrip strength was significantly associated with smaller decline in K-MMSE scores compared to the lowest tertile of handgrip strength in obese women (p value = 0.009). There was no association between handgrip strength and incident cognitive impairment in non-obese women.ConclusionsStrong handgrip strength was associated with reduced risk of cognitive impairment among obese women, but not in non-obese women. Handgrip strength may be a simple and useful marker for predicting future cognitive impairment among obese women.Electronic supplementary materialThe online version of this article (10.1186/s12877-018-0918-9) contains supplementary material, which is available to authorized users.

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Section: Methodsmentioning

confidence: 99%

Association among handgrip strength, body mass index and decline in cognitive function among the elderly women

Jeong¹,

Choi²,

Kim

et al. 2018

BMC Geriatr

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“…The team conducted physical and functional assessments (e.g., anthropometric measurement, handgrip strength, walking speed) and collected and analyzed urine and blood specimens. The details of the KEEP II study have been reported elsewhere [ 20 , 21 ]. The Institutional Review Board at Seoul National University Hospital approved the study protocol (C-1209-006-424).…”

Section: Methodsmentioning

confidence: 99%

“…Socio-demographic data included age, gender, education, household type, house income, occupation, and living location [ 3 , 5 , 6 , 9 , 10 , 11 , 12 , 19 , 20 , 21 ]. Lifestyle data included smoking, drinking, and fruit and vegetable consumption [ 6 , 10 , 12 , 19 , 20 , 21 , 25 ]. “Non-smoker” refers to a person who reported smoking fewer than 20 packs of cigarettes during their lifetime, and “non-drinker” refers to a person who reported (s)he could not or did not drink alcohol (e.g., due to religion).…”

Section: Methodsmentioning

confidence: 99%

“…A large number of studies have reported associations between DEHPs and diverse health effects such as allergies, asthma, and chronic inflammation [ 13 , 15 , 16 , 17 , 18 ]. Recent studies have also found a positive association between levels of DEHP concentration and lung function, handgrip strength, and even depressive symptoms in Korean older adults [ 19 , 20 , 21 ]. The objective of this cohort study was to investigate the association between DEHP exposure and frailty in older adults aged 60 or older in South Korea, an East Asian country with the most rapidly aging population in the world [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between Phthalate Exposure and Frailty among Community-Dwelling Older Adults: A Repeated Panel Data Study

Kim

Lee

Jung

et al. 2021

IJERPH

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Only a few studies have examined the impacts of environmental exposure on frailty. This study investigated the association between phthalates and frailty among community-dwelling older adults. The Korean Elderly Environmental Panel II (KEEP II) study is a repeated panel data study of 800 community-dwelling older adults in South Korea. Frailty was measured with five items defined by Fried and colleagues. Environmental pollutants in the form of two types of metabolites for Di-ethylhexyl phthalate (DEHPs)—Mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and Mono (2-ethyl-5-oxohexyl) phthalate (MEOHP)—were obtained from urine specimens. Analyses were performed using repeated linear mixed models. The concentration levels of both MEOHP and MEHHP in urine were significantly higher in the pre-frail or frail group than its counterparts. While adjusting for covariates, MEOHP level was positively associated with the likelihood of being pre-frail or frail in both males and females; the concentration level of MEHHP also had a positive impact on the likelihood of being pre-frail or frail in females. The DEHP metabolite concentrations were significantly lower among adults with daily fruit consumption in both males and females. DEHPs, measured by metabolite concentrations, may increase the risk of frailty among older men and women; further studies are necessary. The preventive effects of nutrition on DEHP risk should also be further investigated.

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“…While little is known about the effects of MEHP on human skeletal muscle, a decrease in muscle strength in the elderly has been shown to be parallel with increasing urinary MEHP, which was hypothesized to be a result of MEHP-induced oxidative stress and inflammation (24). Furthermore, Corbasson et al (2016) illustrated an association between increased urinary MEHP and decreased lean mass in adults, where lean mass excluded bone mineral content, thus primarily representing muscle mass (25).…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo evidence of bioenergetic metabolism alteration by mono-(2-ethylhexyl) phthalate

Rajkumar

Simba

Ménard

et al. 2020

Preprint

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Background: To better understand the potential alteration of muscle bioenergetic metabolism by the obesogenic toxicant mono-(2ethylhexyl) phthalate (MEHP) the objectives of this research were to determine the: 1) association between urinary MEHP levels and plasma fatty acid levels in women with obesity who participated in National Health and Nutrition Examination Survey (NHANES) studies, and 2) in vitro effects of MEHP on fatty acid, or glucose supported mitochondrial energetics in C2C12 muscle cells.Results: The association between urinary MEHP from NHANES participants with plasma fatty acid levels was studied via secondary data statistical analyses. 14C-palmitic acid oxidation, Seahorse fatty acid oxidation and glycolysis stress tests and western blot analyses were conducted on C2C12 cells exposed to increasing MEHP concentrations. Increased urinary MEHP in women with obesity was associated with increased plasma gamma-linolenic and arachidonic acid levels. C2C12 myotubes exposed to increasing MEHP concentrations, displayed decreased fatty acid oxidation and mitochondrial bioenergetics. Acyl-CoA synthetase long chain 5 (ACSL5) protein level was also upregulated with increasing MEHP exposure in C2C12 myoblasts. Glycolysis was not significantly modified with increased exposure of C2C12 cells to MEHP.Conclusions: MEHP exposure may alter fatty acid utilization at the whole-body level in women with obesity and fatty acid utilization in muscle cells. Our findings are consistent with the idea that women with obesity may be particularly susceptible to the effects of MEHP, which alters fatty acid metabolism in muscle cells.

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Association between phthalate exposure and lower handgrip strength in an elderly population: a repeated-measures study

Cited by 15 publications

References 49 publications

Association among handgrip strength, body mass index and decline in cognitive function among the elderly women

Association among handgrip strength, body mass index and decline in cognitive function among the elderly women

Association between Phthalate Exposure and Frailty among Community-Dwelling Older Adults: A Repeated Panel Data Study

In vitro and in vivo evidence of bioenergetic metabolism alteration by mono-(2-ethylhexyl) phthalate

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