Body mass index is associated with interleukin-1, adiponectin, oxidative stress and ioduria levels in healthy adults

Cruz-Mejía, Saytin; López, Henri Hamil Durán; Meza, Mónica Navarro; Rosas, Irene; Peña, Sol de la; Arroyo-Helguera, Omar

doi:10.20960/nh.1614

Cited by 14 publications

(9 citation statements)

References 1 publication

(2 reference statements)

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“…60 Also, an increase in TAC levels was previously reported in overweight and obese subjects compared to the normal weight group. 61 In the present study, we found a significant decrease in SOD activity and an increase in GPx in overweight and obese subjects compared to the normal weight group. We found a significant increase in TAC in overweight subjects compared to those of normal weight.…”

Section: Discussionsupporting

confidence: 59%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

DMSO

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Purpose: The increase of visceral abdominal fat (VAF) and oxidative stress (OS) are independent predictors for cardiovascular risk. This study aimed to determine the association of VAF with proinflammatory cytokines, oxidants, antioxidants, and oxidative damage to DNA in subjects with normal weight, overweight, and obesity. Patients and Methods: A cross-sectional study that included 21 men and 71 women who attended for a medical check-up was conducted. Dual-energy X-ray absorptiometry (DXA) was used to measure the VAF volume. ELISA and colorimetric techniques were used for chemical analysis.Results: Low activity of superoxide dismutase (SOD) was found in overweight and obese subjects compared to the normal weight group (p=0.005). In contrast, the activity of glutathione peroxidase (GPx) was higher in the overweight and obesity groups compared to the normal weight subjects (p=0.017). The total antioxidant capacity (TAC) was also increased in the overweight group compared to the normal weight group (p=0.04). According to the volume of VAF, the levels of tumor necrosis factor alfa and interleukin 6 showed no differences between subjects with normal and high VAF. Subjects with high VAF show higher levels of 8-isoprostans compared to normal VAF group (p=0.039). Less concentration of 8-oxoguanine-DNA-N-glycosylase-1 (hOGG1) was found in the high VAF group (p=0.032) compared to the normal VAF subjects. VAF was positively correlated with lipoperoxides (LPO) (r=0.27, p<0.05) and 8-isoprostanes (r=0.25, p<0.05). We also found correlations between oxidative stress markers and anthropometric ratios for intra-abdominal fat. The waist-hip ratio was positively correlated with LPO (r=0.30, p<0.05) and TAC (r=0.24, p<0.05). Conclusion: These findings suggest that the predominantly oxidative damage associated with VAF in overweight or obesity is lipoperoxidation and oxidative DNA damage. Alterations in endogenous antioxidant defenses may not be linked to the amount of VAF.

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Section: Discussionsupporting

confidence: 59%

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

García-Sánchez

Gámez-Nava

Cruz

et al. 2020

DMSO

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“…Controversial results have been reported on the association between ADP levels and thyroid hormones for experimental studies on hypo / hyperthyroid animals. In this manner, Aragao et al [13] have reported that serum adiponectin levels of hyperthyroid rats 3.2 fold higher than that of euthyroid, whereas in experimental hypothyroidism did not change serum adiponetcin levels. Chang et al [24] have reported increased adiponectin levels in Graves' disease.…”

Section: Resultsmentioning

confidence: 88%

“…In the experimental studies on hypothyroid and hyperthyroid animals, controversial results regarding the association between ADP levels and thyroid hormones have been reported. Although serum ADP levels were found to be unchanged or increased in hyperthyroid rats, serum ADP levels in hypothyroid rats did not change either [12,13]. ADP mRNA levels in the adipose tissue are reduced in hypothyroid rats when compared to controls, and this reduction is parallel to the reduction in triiodothyronine (T 3 ), T 4 , fT 3 and fT 4 concentrations.…”

Section: Introductionmentioning

confidence: 94%

The effect of thyroid dysfunction and treatment on fat tissue adiponectin levels in rats

2019

Biointerface Res Appl Chem

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Adipose tissue is a hormonal active system that produces and releases leptin, adiponectin and resistin. Seen from this aspect, it may be thought that adiponectin may interact with the thyroid axis. Thyroid function disturbance led to changes on the body weight, muscle volume and adipose tissue. Experimental findings show that adiponectin and thyroid hormones have biological interactin with each other. However, various results have been reported a relationship between thyroid hormones and adiponection levels. The aim of the present study was to determine adipose tissue adiponectin levels in rats with thyroid dysfunction and after treatment. Study was performed on 40 Sprague-Dawley male rats. Groups were designed as 1-control, 2-hypothyroidism (Hypo), 3- hypothyroidism + Thyroxine, 4-hyperthyroidism (Hyper), 5-hyperthyroidism + PTU. At the end of 3 weeks experimental period, adipose tissues of rats were analyed for adiponection by Elisa. Experimental hypothyroidism reduced adipose tissue adiponectin levels, but hyperthyrodism increased. Treatment of hypothyroidism and hyperthyroidism corrected disrupted adiponectin levels to control. The results of the present study show that experimental thyroid dysfunction has affected adipose tissue adiponection levels in rats.

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“…While widely used as a proxy for socioeconomic status [37], more sophisticated measures such as those involving geocoding [38] would provide more detailed information. Another limitation involves the lack of a complete set of data relating to other health measures such as body mass index which might modulate the association between animal exposure, socioeconomic status, and risk of psychiatric disorders [39].…”

Section: Discussionmentioning

confidence: 99%

Exposure to household pet cats and dogs in childhood and risk of subsequent diagnosis of schizophrenia or bipolar disorder

Yolken¹,

Stallings

Origoni

et al. 2019

PLoS ONE

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BackgroundSerious psychiatric disorders such as schizophrenia and bipolar disorder have been associated with environmental exposures in early life. Contact with household pets such as cats and dogs can serve as a source of environmental exposure during these time periods.MethodsWe investigated the relationship between exposure to a household pet cat or dog during the first 12 years of life and having a subsequent diagnosis of schizophrenia or bipolar disorder. These studies were performed in a cohort of 396 individuals with schizophrenia, 381 with bipolar disorder, and 594 controls. The hazards of developing schizophrenia or bipolar disorder associated with first exposure to a household pet cat or dog were calculated using Cox Proportional Hazard and multivariate logistic regression models including socio-demographic covariates.ResultsWe found that exposure to a household pet dog was associated with a significantly decreased hazard of having a subsequent diagnosis of schizophrenia (Hazard Ratio .75, p < .002) Furthermore, a significant decreased relative risk of schizophrenia was detected following exposure at birth and during the first years of life. There was no significant relationship between household exposure to a pet dog and bipolar disorder. There were no significant associations between exposure to a household pet cat and subsequent risk of either a schizophrenia or bipolar disorder diagnosis. However, there were trends towards an increased risk of both disorders at defined periods of exposure.ConclusionsExposure to household pets during infancy and childhood may be associated with altered rates of development of psychiatric disorders in later life.

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Body mass index is associated with interleukin-1, adiponectin, oxidative stress and ioduria levels in healthy adults

Cited by 14 publications

References 1 publication

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

<p>The Effect of Visceral Abdominal Fat Volume on Oxidative Stress and Proinflammatory Cytokines in Subjects with Normal Weight, Overweight and Obesity</p>

The effect of thyroid dysfunction and treatment on fat tissue adiponectin levels in rats

Exposure to household pet cats and dogs in childhood and risk of subsequent diagnosis of schizophrenia or bipolar disorder

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