Body Mass Index Change Between Pregnancies and Small for Gestational Age Births

Cheng, Christine J.; Bommarito, Kerry M.; Noguchi, Akihiko; Holcomb, William L.; Leet, Terry

doi:10.1097/01.aog.0000134526.37657.b0

Cited by 29 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was not totally unexpected as increased BMI is associated with decreased risk of SGA, and preterm birth and obese women have a moderate increased risk for unplanned cesarean section. [26][27][28] Conversely, increases in prepregnancy BMI from overweight to obese have been associated with increased risk of LGA. 29,30 Excessive pregnancy weight gain and retention of weight following pregnancy can lead to higher postpartum BMI and result in a shift from overweight to obese.…”

Section: Discussionmentioning

confidence: 99%

Pre-Pregnancy Overweight Status between Successive Pregnancies and Pregnancy Outcomes

Hoff¹,

Cai²,

Okah

et al. 2009

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Pre-Pregnancy Overweight Status between Successive Pregnancies and Pregnancy Outcomes

Hoff¹,

Cai²,

Okah

et al. 2009

Journal of Women's Health

View full text Add to dashboard Cite

show abstract

“…Moreover, during the IPI, other events such as breastfeeding or major weight changes may take place, which also affect the mother's nutritional status and normal homeostasis. 15,16 However, this could also be a chance finding, as no studies have yet attempted to replicate its results. To further explore this relationship, we conducted a study on the association between IPI and birth defects, using a population-based case-control study design.…”

Section: Introductionmentioning

confidence: 99%

Relationship between interpregnancy interval and birth defects in Washington State

et al. 2011

View full text Add to dashboard Cite

Objective: Interpregnancy interval (IPI) influences numerous adverse perinatal outcomes. IPI's impact on birth defects is unclear. Study Design:We conducted a population-based case-control study, using 1998 to 2008 administrative data from Washington State. A total of 10 772 cases, women whose second of two births resulted in an infant with a birth defect, were compared with 32 310 controls, women whose second of two births did not result in an infant with a birth defect.Result: Compared with mothers with an IPI between 18 to 23 months, those with an IPI <6 months or X60 months had elevated risks of delivering an infant with a birth defect (odds ratio ¼ 1.15, 95% confidence interval: 1.03 to 1.28, and odds ratio ¼ 1.15, 95% confidence interval: 1.04 to 1.26, respectively). Conclusion:We observed a J-shaped relationship between IPI and risk of having an infant with a birth defect. As this is one of the first studies to evaluate this association, confirmatory studies are needed.

show abstract

“…This results in altered blood flow, and possible exposure of the developing fetus to a limited oxygen and nutrient supply. Pre-pregnancy BMI and inadequate maternal weight-gain during pregnancy may also result in restricted nutrient supply, and are additional risk factors for fetal growth restriction [36,37]. We hypothesized that in all conditions predicted to cause limited amino acid availability to the placental/fetal unit, similar adaptive responses aimed at increasing transport capacity, including increased AAT protein levels, may be observed.…”

Section: Introductionmentioning

confidence: 99%

Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR

Aiko

Askew

Aramaki

et al. 2014

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundSufficient amino acid transport activity (AAT) is indispensable for appropriate fetal growth. Studies suggest that placental nutrient uptake activity is responsive to both maternal and fetal nutrient demands. We hypothesize that under conditions of limited nutrient availability to the fetus, as often present in preeclampsia, intrauterine growth restriction (IUGR), and insufficient weight-gain during pregnancy, a general adaptive response aimed to increase amino acid transport activity may be observed in the placenta.MethodA total of 40 placentas from full-term (n = 10) and pre-term (average gestational period = 34.8 weeks, n = 10) normal pregnancies, IUGR (n = 10), and preeclampsia (n = 10) associated pregnancies were looked at by immunohistochemistry followed by relative qualitative scoring to compare expression levels and localization of System L, ASCT2, and mTOR proteins.ResultMicrovillous syncytiotrophoblast (ST) in placenta of pregnancies complicated by IUGR or preeclampsia (PE) showed significant increases in the levels of System L amino acid transport proteins 4F2hc and LAT1 compared to both full-term control and pre-term (early gestation control) pregnancies seperately (p < 0.05). Elevated mTOR protein was uniquely higher in IUGR placentas compared to full-term controls (P = 0.0026). Total cellular ASCT2 transporter protein levels were similar in all groups, however, levels of ASCT2 protein localized to the ST microvillous membrane (MVM) were significantly lower in IUGR compared to both full-term and pre-term pregnancies (P = 0.0006, 0.03, respectively). Additionally, ASCT2 and mTOR protein levels were positively associated with maternal pre-pregnancy BMI (P = 0.046, 0.048, respectively).ConclusionThere are three important findings based upon the present study. First, in conditions of limited nutrient availability, such as PE or IUGR, there is an overall increase in the level of System L and mTOR protein expression in the ST, suggestive of an adaptive response. Second, a decrease in ASCT2 protein at the ST MVM suggests a post-translational event that may decrease AAT activity in IUGR placentas. Third, a physiological link between transporter expression and pre-pregnancy BMI is suggested based upon a positive association observed with ASCT2 and mTOR expression values.

show abstract

Body Mass Index Change Between Pregnancies and Small for Gestational Age Births

Abstract: Increase in interpregnancy BMI lowers SGA risk, but adequate weight gain during pregnancy is more effective.

Cited by 29 publications

References 33 publications

Pre-Pregnancy Overweight Status between Successive Pregnancies and Pregnancy Outcomes

Pre-Pregnancy Overweight Status between Successive Pregnancies and Pregnancy Outcomes

Relationship between interpregnancy interval and birth defects in Washington State

Differential levels of amino acid transporters System L and ASCT2, and the mTOR protein in placenta of preeclampsia and IUGR

Contact Info

Product

Resources

About