Body mass index as the most influential factor of high-sensitivity C-reactive protein in non-diabetic adults

Abstract

BACKGROUND<br />High-sensitivity C-reactive protein (hsCRP) has been widely accepted as a predictor of future cardiovascular risk that reflects a microinflammatory state. Obesity linked to microinflammation increases the prevalence of metabolic disorders and cardiovascular diseases. This study aimed to determine the association between several obesity indices namely body mass index (BMI), waist circumference (WC), body fat percentage (fat), and visceral fat (VF) with hsCRP in non-diabetic adults. <br /><br />METHODS<br />This was a cross-sectional study performed on 80 non-diabetic adults with ages ranging from 20-40 years. The obesity indices BMI, WC, body fat percentage, and VF were measured. We then measured the hsCRP levels using an immunoturbidimetric method. Simple and multiple linear regression tests were used to analyze the association between obesity indices and hsCRP levels. <br /><br />RESULTS<br />Mean of log BMI, log WC, and log VF was 1.41 ± 0.08 kg/m2, 1.93 ± 0.06 cm, and 0.95 ± 0.27 units, respectively. Simple linear regression tests showed that log BMI (â=3.506; p<0.001), log WC (â=3.672; p<0.001), log VF (â=0.833; p<0.001), and log systolic blood pressure (â=3.739; p=0.024) had a significant positive correlation with log hsCRP levels. Further multiple linear regression test showed that log BMI (â=3.772; Beta=0.674; p<0.001) had the greater effect on log hsCRP levels compared to other indices. <br /><br />CONCLUSIONS <br />BMI had a greater influence on hsCRP levels compared to other obesity indices in non-diabetic adults. Body mass index can be used as a better index in predicting hsCRP levels compared to other indices.

The Correlation Between Cardiometabolic Risks and High-Sensitivity C Reactive Protein (Hs-CRP) Levels in Serum Among Young Adults with Overweight and Obesity

“…In our study, there was a significant correlation between body mass index (p = 0.001; r = 0.526) and serum Hs-CRP levels in overweight and obese individuals. This is in line with the research by Mulyamin et al (2021) which stated that body mass index is a factor that affects serum Hs-CRP levels in overweight and obese individuals and in non-diabetic adults [2][11] [20]. Research by Rattu et al [21] in Manado also found a significant positive relationship between body mass index and serum Hs-CRP levels in obese students and no significant relationship between BMI and Hs-CRP levels in non-obese students [21][22].…”

“…This result is consistent with a previous study which found that waist circumference is significantly related to the increase in serum Hs-CRP levels in overweight and obese patients [11]. The anthropometric parameters significantly associated with Hs-CRP are the body mass index and waist circumference [20]. Waist circumference is a parameter of abdominal obesity with a waist circumference > 80 cm for women and > 90 cm for men indicating abdominal obesity or central obesity.…”