Body mass index and uterine receptivity in the oocyte donation model

Wattanakumtornkul, Saranya; Damario, Mark A; Hall, Sharon A; Thornhill, Alan R.; Tummon, Ian S.

doi:10.1016/s0015-0282(03)00595-8

Cited by 90 publications

(61 citation statements)

References 10 publications

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“…The area under the receiver operating characteristic (ROC) curve was 0.51 (95% CI 0.41-0.62), suggesting no relationship between BMI and implantation rate. Likewise, there were no significant differences observed in pregnancy rates between the BMI strata (Wattanakumtornkul et al 2003). Styne-Gross et al (2005) investigated 536 first cycle donor oocyte recipients undergoing embryo replacement.…”

Section: Obesity and The Endometriummentioning

confidence: 96%

“…However, contradictory findings have been reported, and importantly studies varied in design (Cano et al 2001, Bellver et al 2003, 2007, Wattanakumtornkul et al 2003, Styne-Gross et al 2005. It has been proposed that the oocyte donation model provides the best human model for discriminating between the effects of obesity upon the oocyte/embryo and the endometrium and uterine receptivity (Bellver et al 2007).…”

Section: Obesity and The Endometriummentioning

confidence: 99%

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The adverse effects of obesity on conception and implantation

Brewer¹,

Balen²

2010

Reproduction

411

277

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Whilst many multiparous women are obese (body mass index O30 kg/m 2 ), obesity has been associated with impaired fecundity; however, the mechanism which links obesity to reduced fertility remains to be fully elucidated. Obese women, particularly those with central obesity, are less likely to conceive per cycle. Obese women suffer perturbations to the hypothalamic-pituitary-ovarian axis, menstrual cycle disturbance and are up to three times more likely to suffer oligo-/anovulation. A fine hormonal balance regulates follicular development and oocyte maturation, and it has been observed that obesity can alter the hormonal milieu. Leptin, a hormone produced by adipocytes, is elevated in obese women, and raised leptin has been associated with impaired fecundity. Obesity impairs ovulation but has also been observed to detrimentally affect endometrial development and implantation. The expression of polycystic ovary syndrome (PCOS) is regulated, in part, by weight, and so obese women with PCOS often have a more severe phenotype and experience more subfertility. Obesity also impairs the response of women to assisted conception treatments. Weight loss through lifestyle modification or bariatric surgery has been demonstrated to restore menstrual cyclicity and ovulation and improve the likelihood of conception. In this article, we will discuss the effect of obesity upon key reproductive mechanisms and its relation to fertility treatments.

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Section: Obesity and The Endometriummentioning

confidence: 96%

Section: Obesity and The Endometriummentioning

confidence: 99%

The adverse effects of obesity on conception and implantation

Brewer¹,

Balen²

2010

Reproduction

411

277

View full text Add to dashboard Cite

show abstract

“…Researchers have evaluated the impact of increasing donor oocyte recipient BMI on embryonic implantation rate, clinical pregnancy rate, miscarriage rate, and chances of live birth. These studies have yielded conflicting results with several studies demonstrating a BMI-related impact on measures of reproductive success 51,52 and others demonstrating no effect 53,54 . In any case, however, alterations in endometrial gene expression in the peri-implantation period have been noted to be different in obese versus non-obese women 55 .…”

Section: The Endometriummentioning

confidence: 99%

Obesity and reproductive function

Klenov¹,

Jungheim²

2014

Current Opinion in Obstetrics &Amp; Gynecology

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SYNOPSISObesity is associated with multiple adverse reproductive outcomes, but the mechanisms involved are largely unknown. Public health scientists studying obesity and its effects on health outcomes have referred to obesity as a "complex system", defined as a system of heterogeneous parts interacting in nonlinear ways to influence the behavior of the parts as a whole 1,22 . By this definition, human reproduction is also a complex system which may explain some of the difficulty in identifying the mechanisms linking obesity and adverse reproductive function. Despite the difficulties, research on obesity and reproduction is important as there is an epidemic of obesity among reproductive age women with associated consequences for future generations. In this review we discuss the adverse reproductive outcomes associated with obesity and data from translational studies of the mechanisms involved. We conclude with a brief discussion of public health policy as it relates to the treatment of infertility in obese women. Keywords fertility; obesity; reproduction; public health MEASURING OBESITY AND REPRODUCTIVE RISKDisentangling the individual components of obesity associated with poor health outcomes is difficult. Body mass index (BMI) or overall body size adjusted for height, is obviously, the most accessible measure of obesity as the tools for measuring BMI are readily available. On the other hand, adiposity (regional or total body fat), adipokine production, and lifestyle components may also contribute individually or together to overall obesity-related health risk. The bulk of the work relating obesity to health risks has focused on chronic diseases, however, we are learning more about components of obesity that relate to reproductive risk.

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“…There are studies which stated that endometrial receptivity and reproductive outcome are broken as BMI increases. [15][16][17] The fact that the correlation between BMI and β-hCG is broken in the triplet pregnancies in this studies may be caused by the insufficient number of the patients in that group.…”

Section: Discussionmentioning

confidence: 77%

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

Kalem¹,

Kalem²,

Gürgan³

2017

TJRMS

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-hCG (beta-human chorionic gonadotrophin) is a pregnancy-associated molecule produced by implanted blastocysts and trophoblastic cells. β-hCG as one of the earliest embryonal signals may be a major regulator in the paracrine embryo-endometrial communication.1,2 β-hCG measurement in serum is a method used routinely for pregnancy test after the IVF (invitro fertilization) procedure.3 Serial measurements of β-hCG is a marker which is also used for distinguishing pregnancies running their course from ectopic pregnancy or spontaneous pregnancy losses in early pregnancy. [4][5][6] In increasing number of recent studies, it has become a current issue that β-hCG levels in early A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : The purpose of this study is to investigate the parameters of female, male and cycles that could affect post-ART (assisted reproductive techniques)-pregnancy initial beta hCG value. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In this retrospective study, data of 3056 individuals who had become pregnant with IVF/ICSI at a private IVF center and between 2006 and 2016 and whose pregnancies continued for over 12 weeks were evaluated. Initial beta-hCG values of these pregnancies were compared with parameters of mothers, fathers and cycles. R Re es su ul lt ts s: : It was seen in this study that there is a negative correlation between the initial beta-hCG values of pregnancies achieved by assisted reproductive techniques and mothers BMI values and a positive correlation between those beta-hCG values and the embryo transfer day. C Co on nc cl lu us si io on n: : The data obtained in the study need to be supported with larger series in the future. It is also thought that these data may contribute to the literature which tries to achieve a β -hCG cut-off value in the determination of pregnancy outcome. Ya zış ma Ad re si/Cor res pon den ce:

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Body mass index and uterine receptivity in the oocyte donation model

Cited by 90 publications

References 10 publications

The adverse effects of obesity on conception and implantation

The adverse effects of obesity on conception and implantation

Obesity and reproductive function

Factors Affecting Initial Beta-HCG Values in Pregnancies Achieved by Assisted Reproductive Techniques

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