Body-Mass Index and Progression of Hepatitis B: A Population-Based Cohort Study in Men

Yu, Miao; Shih, Wei-Liang; Lin, Chih–Lin; Liu, Chun‐Jen; Jian, Jhih-Wei; Tsai, Keh–Sung; Chen, Chien‐Jen

doi:10.1200/jco.2008.16.1075

Cited by 115 publications

(113 citation statements)

References 35 publications

Supporting

Mentioning

103

Contrasting

Order By: Relevance

“…Stattin et al 21 also reported that adjustment for BMI had no material effect on risk estimates of hyperglycemia and cancer risk. A recent Taiwanese study 36 prospectively followed 2,903 male hepatitis B virus surface antigen-positive government employees for a mean of 14.7 years, and . This study thus concluded that excess body weight is involved in the transition from healthy hepatitis B carrier state to hepatocellular carcinoma among men.…”

Section: Discussionmentioning

confidence: 99%

Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications

Chen

2010

Hepatology

View full text Add to dashboard Cite

We prospectively investigated 615,532 diabetic patients and 614,871 age-matched and sexmatched control subjects selected from National Health Insurance claims for malignant neoplasms of liver and biliary tract (International Statistical Classification of Diseases and Related Health Problems, 9th edition, codes 155 and 156, respectively) between 2000 and 2006. The person-year approach with Poisson assumption was used to estimate the hazard rates. We also evaluated the age-specific and sex-specific relative risks of these two malignancies in relation to diabetes with Cox proportional hazard regression model with adjustment for potential confounders. The overall hazard rate of malignant neoplasm of the liver was 32.76 and 17.41 per 10,000 patient-years, respectively, for diabetic men and women; the corresponding figures for biliary tract neoplasm were much lower at 1.42 and 1.60 per 10,000 patient-years. Compared with control subjects, diabetic patients had a two-fold increased risk of malignant neoplasm of the liver, but this risk was attenuated by adjusting for selected clinical risk factors (hazard ratio [HR] 1.21; 95% confidence interval [CI] 1.17-1.25). Additionally, diabetic patients were associated with increased risk of biliary neoplasms with an approximate magnitude of 20%-30%, but the HR was attenuated and became insignificant after adjustment for clinical risk factors (HR 1.07; 95% CI 0.95-1.21). Diabetic patients with cirrhosis had the highest relative risk of liver neoplasm (HR 85.25;), whereas those with cholangitis had the highest risk of biliary tract neoplasm (HR 70.30;) compared with control subjects without any clinical risk factors. Conclusion: This population-based study confirms the association of diabetes with liver neoplasm and suggests that diabetic patients with certain clinical risk factors should be educated for strict adherence of liver neoplasm screening. (HEPATOLOGY 2010;52:155-163)

show abstract

Section: Discussionmentioning

confidence: 99%

Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications

Chen

2010

Hepatology

View full text Add to dashboard Cite

show abstract

“…The prevalence of metabolic syndrome among elderly women is the highest among all of the age-and sex-specific groups in Taiwan. HCC has been linked to nonalcoholic fatty liver disease (NAFLD), the hepatic manifestation of obesity and related metabolic disorders such as diabetes [35][36][37]. In Taiwan, a longitudinal cohort study indicated that excess body weight is involved in the transition from a healthy HBV carrier to HCC and liver-related death among men [38]. Another study revealed that more than 100-fold increased risk of HCC in HBV or HCV carriers with both obesity and diabetes [39].…”

Section: Geographic Variationsmentioning

confidence: 98%

Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan

Hung

Horng

Yen

et al. 2015

Journal of Hepatology

View full text Add to dashboard Cite

“…On another note, chronic hepatitis B patients with obesity and diabetes also have higher risk of HCC [24,25]. This is partly explained by the increased fibrosis progression in patients with metabolic syndrome [26].…”

Section: Patient Factorsmentioning

confidence: 98%

Can we use HCC risk scores to individualize surveillance in chronic hepatitis B infection?

Wong

Janssen

2015

Journal of Hepatology

100

108

View full text Add to dashboard Cite

Chronic hepatitis B is one of the leading causes of hepatocellular carcinoma (HCC) worldwide. Accurate prediction of HCC risk is important for decisions on antiviral therapy and HCC surveillance. In the last few years, a number of Asian groups have derived and validated several HCC risk scores based on well-known risk factors such as cirrhosis, age, male sex and high viral load. Overall, these scores have high negative predictive values of over 95% in excluding HCC development in 3 to 10 years. The REACH-B score was derived from a community cohort of non-cirrhotic patients and is better applied in the primary care setting. In contrast, the GAG-HCC and CU-HCC scores were derived from hospital cohorts and include cirrhosis as a major integral component. While the latter scores may be more applicable to patients at specialist clinics, the diagnosis of cirrhosis based on routine imaging and clinical parameters can be inaccurate. To this end, recent developments in non-invasive tests of liver fibrosis may further refine the risk prediction. The application of HCC risk scores in patients on antiviral therapy and in other ethnic groups should be evaluated in future studies.

show abstract

Body-Mass Index and Progression of Hepatitis B: A Population-Based Cohort Study in Men

Abstract: This longitudinal cohort study indicates that excess body weight is involved in the transition from healthy HBV carrier state to HCC and liver-related death among men.

Cited by 115 publications

References 35 publications

Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications

Risk of malignant neoplasms of liver and biliary tract in diabetic patients with different age and sex stratifications

Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan

Can we use HCC risk scores to individualize surveillance in chronic hepatitis B infection?

Contact Info

Product

Resources

About