Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan

Hung, Giun Yi; Horng, Jiun Lin; Yen, Hsiu Ju; Lee, Chih Ying; Li, Lin

doi:10.1016/j.jhep.2015.07.032

Cited by 83 publications

(82 citation statements)

References 23 publications

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“…Our results identified HBV infection to be present in 81.5% of C&A with HCC, which is similar to the prevalence of adult HCC in our hospital 21,22. In accordance with other studies, we found that HCC was more common in males than in females (4:1) 3,5. AFP is a useful diagnostic marker for HCC, and roughly 50–70% of adults with HCC have increased levels of AFP,3,23 compared with >90% in C&A in our study.…”

Section: Discussionsupporting

confidence: 91%

“…The incidence of HCC in children and adolescents (C&A) is higher than that for hepatoblastoma, a pattern that is different from that reported in Western countries 4,5. Unlike HCC in adults, which commonly arises in the setting of prolonged chronic hepatitis and cirrhosis,6 tumors in C&A have been observed with HBV infection acquired perinatally or due to inherited metabolic disorders 7,8.…”

Section: Introductionmentioning

confidence: 96%

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Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment

Wang

Mao

Liu

et al. 2017

Journal of Gastrointestinal Surgery

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BackgroundHepatocellular carcinoma (HCC) occurs rarely in children and adolescents (C&A), and its clinical characteristics, prognostic factors, and treatment were rarely explored.MethodsThis retrospective study focused on 65 HCC patients aged ≤20 years from August 1994 to August 2012. Cox regression models and Kaplan–Meier curves were used to investigate prognostic factors and compare overall survival (OS), respectively.ResultsWe found 61.5% of patients to have multiple tumors, 30.8% to have portal vein tumor thrombus, and 16.9% to have distant metastasis. Diameter of tumors was 10.2 ± 4.1 cm. OS at 5 years was 15.8%. Multivariate analyses showed initial treatment (P < 0.001) to be a predictor for OS. For moderate-stage HCC, the median OS of patients who underwent resection was longer than that of patients who underwent transarterial chemoembolization (TACE) or supportive treatment (ST) (P < 0.001). For advanced-stage HCC, the median OS of patients who underwent TACE was longer than that of patients who underwent ST (P = 0.045).ConclusionsHCC in C&A tends to be more advanced than that in adults, and resection remains the mainstay of treatment for those patients. Moreover, compared with ST, TACE may benefit C&A with moderate- and advanced-stage HCC, which needs further study.Electronic supplementary materialThe online version of this article (doi:10.1007/s11605-017-3420-3) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 96%

Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment

Wang

Mao

Liu

et al. 2017

Journal of Gastrointestinal Surgery

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“…Alternatively, increased use of hepatitis B vaccination and CHB treatment by the younger population has reduced the incidence of HCC in the younger age groups; as this does not benefit the patients with CHB from the prevaccination or treatment eras, the mean age of HCC development is shifted to an older age. This has been shown by Hung and colleagues39 in a study in which elderly patients (>65 years) with HCC comprised 49.1% of their cohort and upward trends of HCC incidence were observed only in elderly patients. Similarly, Seto et al40 have recently shown that the decline in age‐adjusted HCC incidence in age groups <65 years old in Hong Kong is likely due to higher use of nucleoside analogues by the younger population.…”

Section: Discussionmentioning

confidence: 64%

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Goh

Chang

et al. 2017

Hepatology Communications

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Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers globally. With advances in therapy for chronic viral hepatitis, changing social circumstances, and increasing practice of HCC surveillance, the epidemiology of HCC is expected to change over time. We explored the temporal trends in HCC in Singapore, a multiethnic Asian country, over the last 3 decades. Patients with HCC were prospectively enrolled and stratified into two cohorts (C1, 1988‐2002; C2, 2003‐2016). Patient and tumor characteristics, management, and survival were compared between the two cohorts, and a survival census was performed on October 31, 2015. There were 1,401 patients, and the mean age at diagnosis of HCC for C1 and C2 was 60.1 and 63.5 years, respectively. Male patient preponderance decreased significantly, with the male to female ratio falling from 5.2:1 to 3.9:1 between C1 and C2. Hepatitis B, although still the predominant risk factor for HCC, showed a significant decline from C1 to C2 (76.5% to 68.2%), while the nonviral etiology increased significantly over the same period (14.4% versus 25.0%, respectively). Significantly more patients in C2 than C1 were diagnosed through surveillance (39.2% versus 11.3%, respectively) and had better physical performance (Eastern Cooperative Oncology Group 0, 62.1% versus 20.4%, respectively). While Child‐Pugh status was comparable, significantly more patients in C2 than C1 had early stage disease (Barcelona Clinic Liver Cancer 0‐A, 39.5% versus 7.4%, respectively), which translated into significantly higher median survival (18.6 months versus 3.8 months, respectively). Conclusion: Over the past 3 decades, hepatitis B‐related HCC has been decreasing while HCC due to nonviral etiology has been increasing significantly. Surveillance to diagnose early stage HCC is important in improving the outcome of HCC. (Hepatology Communications 2017;1:564–571)

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“…Hepatocellular carcinoma (HCC) is the fifth more common cancer in the world and its incidence is increasing in the elderly population …”

Section: Introductionmentioning

confidence: 99%

Management and prognosis of hepatocellular carcinoma in the elderly: Results of an in‐field multicenter cohort study

Borzio

Dionigi

Vitale

et al. 2017

Liver International

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Changing incidence patterns of hepatocellular carcinoma among age groups in Taiwan

Cited by 83 publications

References 23 publications

Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment

Hepatocellular Carcinoma in Children and Adolescents: Clinical Characteristics and Treatment

Deciphering the epidemiology of hepatocellular carcinoma through the passage of time: A study of 1,401 patients across 3 decades

Management and prognosis of hepatocellular carcinoma in the elderly: Results of an in‐field multicenter cohort study

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