Body Mass Index and predisposition of patients to knee osteoarthritis

Afolabi, Hafeez Abiola; Zakaria, Zaidi; Hashim, Mohd Nizam Md; Vinayak, C. Rajkumar; Shokri, Amran Ahmed

doi:10.1016/j.obmed.2019.100143

Cited by 9 publications

(6 citation statements)

References 38 publications

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“…Pain is the predominant symptom of OA [ 1 ]. Knee osteoarthritis (KOA) is one of the top ten causes of disability worldwide [ 2 , 3 , 4 ], accounting for more than 80% of the entire OA disease burden [ 5 ]. Clinical OA, as defined by symptoms and physical findings, affects about 27 million US individuals and 8.5 million UK individuals [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

et al. 2022

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The most prevalent joint disease is osteoarthritis (OA), which affects an estimated 240 million individuals worldwide. Knee osteoarthritis (KOA) is one of the top 10 causes of disability worldwide. The aim of this study is to systematically evaluate the effect of circuit training (CT) on patients with KOA. We searched through PubMed, Scopus, ScienceDirect, Cochrane, and Google Scholar up to 12 February 2022. We used random-effects statistical analysis for continuous variables and reported the results as a standardized mean difference (SMD) with 95 percent confidence intervals (CI). Seven trials involving 346 patients were included. A significant improvement in the intervention group was observed for the parameter, pain level (SMD −0.96, 95% CI −1.77 to −0.14; p = 0.02; seven trials, 346 participants; high quality evidence), while no significant improvement was found in physical function (SMD 0.03, 95% CI −0.44–0.50; p = 0.89; five trials, 294 participants; high-quality evidence), quality of life (SMD −0.25, 95% CI −1.18–0.68; p = 0.60; three trials, 205 participants; high-quality evidence), the activity of daily living (SMD 0.81, 95% CI −0.85–2.48; p = 0.34; three trials, 223 participants; high-quality evidence), and knee stiffness (SMD −0.65, 95% CI −1.96–0.66; p = 0.33; two trials, 71 participants; high-quality evidence). The findings in this meta-analysis suggest that CT could effectively complement the conventional treatment of KOA, particularly in alleviating pain. However, comprehensive data on the guidelines for the CT approach would be needed to adequately examine the effects of CT on quality of life and biochemical markers in patients with KOA.

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Section: Introductionmentioning

confidence: 99%

Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

et al. 2022

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“…Furthermore, obesity is associated with other co-morbidities that are no less dangerous than obesity itself like essential hypertension, atherosclerosis, coronary artery diseases, type 2 diabetes mellitus, cerebrovascular strokes, and osteoarthritis (Afolabi et al, 2019(Afolabi et al, , 2020 These diseases, by themselves or their treatment, affect body wellbeing. So, they make the patient more susceptible to get COVID-19 infection.…”

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confidence: 99%

The mutual effects of COVID-19 and obesity

et al. 2020

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The mutual effects of COVID-19 and obesity December 31st, 2020, is the day on which the World Health Organization (WHO) was informed about the birth of a new virus belongs to CORONA viruses family causing coronavirus disease 2019 (COVID-19) (Zhu et al., 2020). On March 11th, 2020, the WHO announced to the world the confirmation of COVID-19 as pandemic after causing 1,776,867 confirmed cases and 111,828 confirmed deaths (Zhu et al., 2020). COVID-19 is known to cause lung injury and acute respiratory distress syndrome. However, does it cause overweight or obesity? Is it dangerous to be obese and get COVID-19?Overweight and obesity are defined as excessive fat accumulation, so they represent a risk to health. Most of the world's populations live in countries where overweight and obesity kill more people than underweight. But will the world notice an increase in obesity during this era of the COVID-19 epidemic?One gets obese due to the consumption of too many calories to be used by the body. This occurs due to eating energy-dense foods that are rich in fat and sugar and decrease in physical activity (Smethers and Rolls, 2018). Changes in diet and lifestyle are usually due to environmental changes, which are evident during this period of the pandemic, curfew, and quarantine. All governments that got COVID-19 in their countries have started a curfew until further notice. This leads to a change in lifestyle and a decrease in exercise practice in their populations. So, in addition to work stops, the people in these countries stopped working and going to gyms or parks to do exercise or even doing at home. Many people may become stressed, depressed, or unable to do any form of exercise and others eating more foods without any kind of activities as a result of bad news of COVID-19 spread, which may result in weight gain and becoming obese (Rodríguez et al., 2020).As COVID-19 pandemic continues sweeping the world, it looks like that it doesn't have effects on physical health only. Still, also it has its burdens on psychological health through fear of catching the virus, worrying about family, social isolation, financial pressure, rumors everywhere, and information overload. These all can lead to increased stress & anxiety levels, which will lead to more physical health issues, including obesity. Previous study reported an association between chronic stress with obesity, higher energy intake & lower diet quality (Isasi et al., 2015). Stress can affect body weight through biological behavioral & psychological mechanisms.Biological mechanisms:• Activation of the hypothalamo-adrenal-pituitary axis, that leads to releasing cortisol, which can affect body weight by promoting eating by stimulating eating on its own, decreasing brain sensitivity to Leptin potentiating reward pathway (Schulte et al., 2015).

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“…This will increase the production of pro-inflammatory cytokines. Then adipose tissue will produce adipokines that trigger synovial inflammation, cartilage degradation, and bone matrix remodeling [24], [25], [26]. Adipose tissue also secretes leptin; increasing leptin levels will increase the synthesis of pro-inflammatory cytokines and cause accelerated cartilage degradation.…”

Section: Discussionmentioning

confidence: 99%

The Association between Modifiable Risk Factor with Inflammatory Marker in Knee Osteoarthritis Women

Arnadi

Afriwardi²,

Ali³

et al. 2022

Open Access Maced J Med Sci

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Background: IL-1β and TNF-α are vital inflammatory cytokines in the pathophysiological process of Osteoarthritis (OA). Several risk factors can increase the expression of these cytokines, such as BMI, physical activity, and menopausal status. Aims: This study aims to determine the relationship of modifiable factors with synovial fluid IL-1β and TNF-α levels in knee OA women. Methods: The cross-sectional study was conducted at the orthopedic poly hospital Arifin Achmad Riau Province and Ibnu Sina Hospital in Pekanbaru City. A total of 93 women with knee OA were taken as samples by consecutive sampling. Data were obtained directly from respondents by conducting interviews using a questionnaire, measuring weight and height, examining levels of IL-1β and TNF-α from the synovial fluid using the enzyme-linked immunosorbent assay (ELISA) method. The data were processed computerized using the Person correlation test, One Way Anova, and t-Test. The statistical analysis results were considered significant if the p-value was 0<05. Results: the average age of subjects was 60.67 + 9.99 years, 87.8% aged > 40 years, 84.9% had menopause, and at most had moderate physical activity degrees (51.6%). The mean BMI was 27.18+4.17, the average of IL-1β 424.73+188.01 pg/mL, and TNF-α 105,17+48.98 ng/L. There was a significant positive correlation with moderate strength between BMI and levels of IL-1β and TNF-α synovial fluid (p=0.037, r=0.217, and p=0.047, r=0.207). Conclusion: BMI is a risk factor for IL-1β and TNF-α levels in synovial fluid of knee joints in women with OA, but physical activity and menopausal status are not risk factors.

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Body Mass Index and predisposition of patients to knee osteoarthritis

Cited by 9 publications

References 38 publications

Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

Effects of Circuit Training on Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis

The mutual effects of COVID-19 and obesity

The Association between Modifiable Risk Factor with Inflammatory Marker in Knee Osteoarthritis Women

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