Body mass index and obstetric outcomes in Saudi Arabia: a prospective cohort study

El‐Gilany, Abdel‐Hady; Hammad, Sabry Mohamed

doi:10.4103/0256-4947.67075

Cited by 48 publications

(66 citation statements)

References 25 publications

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“…From the Pearson correlation value (Table 4 and Figure 3) then shows a linear correlation found for all trimester levels between body mass index and other indices. This is in agreement to finding from a recent study in Saudi Arabia according to El-Gilary and Hammad [15]. However; WHtR show a significant positive rank correlation; with BMI as an independent variable in first trimester alone with value against a (r=0.165) in WHtR.…”

Section: Discussionsupporting

confidence: 92%

Evaluation of Basal Metabolic Index and Waist to Height Ratio as Anthropometric Indicators of Obesity Among Pregnant Women in Port Harcourt, Nigeria

Wb¹,

Wadioni²

2018

Insights Biomed

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Excess body fat deposition is known to be unhealthy. There have been several discourses on defined anthropometric indices for the assessment and a better prediction of obesity in pregnant women. This is because certain cut-off values relating to obesity in pregnant subjects are highly influenced by age, sex, ethnicity and trimesters of pregnancy. This study is aimed at investigating the use of two basic anthropometric indices to measure obesity and evaluate its prevalence in the different trimesters of pregnancy. The research is a prospective study involving 460 pregnant women in the sample proportion of 110, 110, 240 in the 1 st , 2 nd , 3rd trimesters respectively chosen randomly from antenatal clinic of the Rivers State Primary Health care centre, Rumukuta, Port Harcourt, Nigeria. Measurements of height, weight, hip circumference (HP) were obtained. Body mass index (BMI) was calculated from values of height and weight. Waist to height ratio (WHtR) was also calculated from waist and hip values. The result showed a BMI prevalence of 3.6%, 7.3% and 0.8%; WHtR prevalence of 56.4%, 51.8% and 40% all in the 1 st , 2 nd and 3 rd trimesters respectively. A negative linear correlation was shown between the other indices and BMI as an independent variable in first trimester with value (r= -0.015) against a (r= 0.165) in WHtR. There was an association of WHtR against BMI with no statistically significant difference at level of 95% (p<0.05). Generally, the study provides a low prevalence of BMI and a high prevalence of WHtR in relation to WHO values as well as establishing 1 st trimester as a good indicator of obesity in pregnant women and WHtR as a better predictor of obesity in pregnant women in the population studied. The results of this study are therefore recommended as a guide for clinical judgement in preventive comprehensive health care services on obesity management.

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Section: Discussionsupporting

confidence: 92%

Evaluation of Basal Metabolic Index and Waist to Height Ratio as Anthropometric Indicators of Obesity Among Pregnant Women in Port Harcourt, Nigeria

Wb¹,

Wadioni²

2018

Insights Biomed

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“…However, this can be excluded in our study, as food and water consumption throughout pregnancy did not differ between the EtOH and Control dams. Additionally, there were no differences in other maternal parameters known to affect offspring metabolic outcome, such as obesity (Whitaker, ; El‐Gilany & Hammad, ; Janjua et al . ), gestational weight gain (Margerison Zilko et al .…”

Section: Discussionmentioning

confidence: 99%

Prenatal alcohol exposure programmes offspring disease: insulin resistance in adult males in a rat model of acute exposure

Nguyen

Steane

Moritz

et al. 2019

The Journal of Physiology

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Key points Prenatal alcohol exposure has the potential to affect fetal development and programme chronic disease in offspring. Previous preclinical models typically use high, chronic doses of alcohol throughout pregnancy to examine effects on offspring, particularly on the brain and behaviour. In this study we use a rat model of moderate, acute, prenatal alcohol exposure to determine if this can be detrimental to maintenance of glucose homeostasis in adolescent and adult offspring. Although female offspring were relatively unaffected, there was evidence of insulin resistance in 6‐month‐old male offspring exposed to prenatal alcohol, suggestive of a pre‐diabetic state. This result suggests that even a relatively low‐dose, acute exposure to alcohol during pregnancy can still programme metabolic dysfunction in a sex‐specific manner. Abstract Alcohol consumption is highly prevalent amongst women of reproductive age. Given that approximately 50% of pregnancies are unplanned, alcohol has the potential to affect fetal development and programme chronic disease in offspring. We examined the effect of an acute but moderate prenatal alcohol exposure (PAE) on glucose metabolism, lipid levels and dietary preference in adolescent and/or adult rat offspring. Pregnant Sprague–Dawley rats received an oral gavage of ethanol (1 g kg−1 maternal body weight, n = 9 dams) or an equivalent volume of saline (control, n = 8 dams) at embryonic days 13.5 and 14.5. PAE resulted in a blood alcohol concentration of 0.05–0.06% 1 h post‐gavage in dams. Fasting blood glucose concentration was not affected by PAE in offspring at any age, nor were blood glucose levels during a glucose tolerance test (GTT) in 6‐month‐old offspring (P > 0.5). However, there was evidence of insulin resistance in PAE male offspring at 6 months of age, with significantly elevated fasting plasma insulin (P = 0.001), a tendency for increased first phase insulin secretion during the GTT and impaired glucose clearance following an insulin challenge (P = 0.007). This was accompanied by modest alterations in protein kinase B (AKT) signalling in adipose tissue. PAE also resulted in reduced calorie consumption by offspring compared to controls (P = 0.04). These data suggest that a relatively low‐level, acute PAE programmes metabolic dysfunction in offspring in a sex‐specific manner. These results highlight that alcohol consumption during pregnancy has the potential to affect the long‐term health of offspring.

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“…13 A prospective study in Saudi Arabia also reported an increased risk of GDM and pre-eclampsia with obesity. 14 In a large populationbased 15-year cohort study, obese women showed an increased risk of pregnancy-induced hypertension, with an adjusted OR of 2.38 and 3.00 for moderate and severe obesity, respectively. 15 McDonald et al conducted a systematic review and meta-analysis of 84 studies (including 64 cohort and 20 case-control studies) on 1,095,834 women; the authors concluded that obese women had a higher risk of preterm delivery (OR: 1.24; 95% CI: 1.13-1.27).…”

Section: Discussionmentioning

confidence: 99%

Implications of Early Pregnancy Obesity on Maternal, Fetal and Neonatal Health: Retrospective cohort study from Oman

Zutshi

Santhosh

Sheikh

et al. 2018

Sultan Qaboos Univ Med J

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abstract:Objectives: This study aimed to determine the prevalence of early pregnancy obesity among Omani women and to review maternal antenatal complications, intrapartum and postpartum events and neonatal complications among such women in comparison to women of normal weight. Methods: This retrospective cohort study included 2,652 pregnant Omani women who delivered at the Royal Hospital, Muscat, Oman, between November 2011 and April 2012. The patients' electronic medical records were reviewed for antenatal, intrapartum and postpartum data. Body mass index was measured during the first trimester (≤12 gestational weeks) and classified according to the World Health Organization categories. Maternal and neonatal complications were compared between obese women and those of normal weight. Obstetric outcomes in uncomplicated pregnancies were also compared. Results: In the study cohort, there were 901 (34%) obese women and 912 (34.4%) women of normal weight; of these, 440 (48.8%) and 672 (73.7%) had uncomplicated pregnancies, respectively. Obese women had a significantly increased incidence of gestational diabetes (relative risk [RR]: 2.23; 95% confidence interval [CI]: 1.70-2.92; P <0.01), gestational hypertension (RR: 3.04; 95% CI: 1.63-5.65; P <0.01), Caesarean delivery (RR: 1.48; 95% CI: 1.08-2.03; P <0.01), postpartum haemorrhage (RR: 2.10; 95% CI: 1.11-4.10; P = 0.01) and fetal macrosomia (RR: 2.71; 95% CI: 1.21-6.09; P <0.01). Conclusion: Approximately one-third of the studied Omani women were obese. These women had a significantly increased risk of various maternal antenatal complications, intrapartum and postpartum events and neonatal complications. Keywords

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Body mass index and obstetric outcomes in Saudi Arabia: a prospective cohort study

Cited by 48 publications

References 25 publications

Evaluation of Basal Metabolic Index and Waist to Height Ratio as Anthropometric Indicators of Obesity Among Pregnant Women in Port Harcourt, Nigeria

Evaluation of Basal Metabolic Index and Waist to Height Ratio as Anthropometric Indicators of Obesity Among Pregnant Women in Port Harcourt, Nigeria

Prenatal alcohol exposure programmes offspring disease: insulin resistance in adult males in a rat model of acute exposure

Implications of Early Pregnancy Obesity on Maternal, Fetal and Neonatal Health: Retrospective cohort study from Oman

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