Body fat distribution in men with angiographically confirmed coronary artery disease

Hauner, Hans; Stangl, Karl; Schmatz, Christian; Burger, K; Blömer, H; Pfeiffer, Ernst-Friedrich

doi:10.1016/0021-9150(90)90112-v

Cited by 48 publications

(29 citation statements)

References 25 publications

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“…This is in line with several crosssectional angiographic studies that failed to demonstrate an association between BMI and the prevalence of CAD in patients undergoing coronary angiography. [18][19][20] In agreement with our investigation, two recent prospective investigations on women undergoing coronary angiography failed to detect a significant association between BMI and adverse vascular events. 21,22 Even an inverse association between BMI and cardiac mortality has been described in coronary patients after percutaneous coronary intervention.…”

Section: Discussionsupporting

confidence: 91%

“…Several cross-sectional angiographic studies have demonstrated an association between angiographic CAD and measures of central obesity. [18][19][20] In extension to these data we report that central obesity (in contrast to overall obesity) is an important predictor of vascular mortality both among men and women undergoing coronary angiography for the evaluation of CAD. It has been suggested that WCf is a better estimate of central obesity than WHR; 27 however, others find a comparable performance of the two parameters of central obesity.…”

Section: Discussionmentioning

confidence: 81%

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Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

et al. 2005

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OBJECTIVE:To prospectively investigate the impact of total and central obesity on vascular mortality in patients undergoing coronary angiography. DESIGN: Prospective cohort study; mean follow-up 2.2 y. SUBJECTS: Men (n ¼ 513) and women (n ¼ 243) undergoing coronary angiography for the evaluation of coronary artery disease. MEASUREMENTS: Body mass index (BMI) was used as a measure of total obesity; waist-to-hip ratio (WHR) and waist circumference (WCf) as measures of central obesity. The primary study end point was vascular mortality; secondary study end points were total mortality, major coronary events, and cumulative vascular events. RESULTS: For both genders, BMI, WHR, and WCf correlated significantly with fasting plasma glucose, with HOMA insulin resistance, with triglycerides, and inversely with HDL cholesterol (Po0.001 for all correlations). In Cox regression analysis adjusting for age, gender, smoking, and total cholesterol, BMI was not associated with any study end point. In contrast, WHR (standardized adjusted odds ratios (OR) 2.01, 95% CI 1.02-3.93 for men and 2.63, 95% CI 1.38-5.00 for women), and WCf (OR ¼ 2.31, 95% CI 1.16-4.60 for men and 8.71, 95% CI 1.78-42.68 for women) proved independently predictive of vascular mortality. Additional adjustment for diabetes and hypertension did not substantially alter these results. Also, the predictive value of WHR and Wcf was retained after adjustment for drug treatment and the presence of significant coronary artery disease at baseline. Further, WHR and WCf were associated with total mortality, major coronary events, and cumulative vascular end points. CONCLUSION: Both total and central obesity are associated with insulin resistance and with an atherogenic lipoprotein profile. However, only central obesity is significantly and independently predictive of the 2-y vascular mortality in coronary patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 81%

Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

et al. 2005

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“…However, it is unlikely that these measurement problems were differentially large enough to explain the discrepancy between this study and others employing similar measuring methods to determine WHR. 5,9,10,28,32,33 The absence of a positive relationship to WHR in the present study may also be attributed to the racial difference in cultural and genetic backgrounds, as the Seven Countries Study showed a differential pro®le of risk factors for coronary heart disease in Japan. 21 However, two relevant studies on the Japanese 11 and Japanese Americans 42 afforded positive ®ndings.…”

Section: Discussionmentioning

confidence: 55%

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

et al. 2001

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OBJECTIVE:To investigate the relation of the obesity and body-fat distribution with angiographically de®ned coronary atherosclerosis. DESIGN: Cross-sectional study in a clinical setting. SUBJECTS: Three hundred and twenty men (median age, 59 y) and 212 women (median age, 67 y) who underwent coronary angiography for suspected or known coronary heart disease at 5 cardiology departments between September 1996 and August 1997. Patients with disease duration b1 y were excluded. MEASUREMENTS: The body mass index (BMI) and the waist to hip circumference ratio (WHR) were used as main exposure variables, and either the presence of signi®cant coronary stenosis or the Gensini's score ( 10 vs`10) as an outcome variable, in a sex-speci®c multiple logistic regression analysis controlling for age, hospital, and other coronary risk factors. RESULTS: Among male patients, BMI was progressively higher with an increasing number of vessels involved (P trend 0.05); the adjusted odds ratios for the presence of signi®cant stenosis across quartiles of BMI were 1.0 (reference), 1.1, 1.9 and 2.5 (P trend 0.02), and the positive association was more pronounced for younger patients. Among females, however, such associations were not evident. Employing the Gensini's score as an outcome gave similar results. WHR was not signi®cantly associated with either outcome regardless of sex. CONCLUSION: These results suggested that BMI was predictive of coronary stenosis among male patients, but not among female patients. Unlike most previous studies, this study failed to detect a positive association with WHR.

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“…Estudos recentes sugerem que a variação da distribuição anatômica da gordura corporal é importante indicador morfológico relacionado com complicações endócrinas e metabólicas predisponentes ao aparecimento e desenvolvimento de doenças cardiovasculares [1][2][3] . Indivíduos com essa disposição centrípeta da gordura corporal tendem a apresentar maior incidência de diabetes 4,5 , hipertensão 6,7 e alterações desfavoráveis no perfil das lipoproteínas plasmáticas [8][9][10][11] .…”

Section: Distribuição De Gordura Corporal Pressão Arterial E Níveis unclassified

Distribuição de gordura corporal, pressão arterial e níveis de lipídios-lipoproteínas plasmáticas

Guedes¹,

Guedes²

1998

Arq. Bras. Cardiol.

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Purpose -To study associations between FAT distribution and blood pressure levels and concentrations of lipids and lipoproteins, irrespective of body fat content and physical activity.Methods -A sample of 62 subjects of both genders aging 20-45 years-old Estudos recentes sugerem que a variação da distribuição anatômica da gordura corporal é importante indicador morfológico relacionado com complicações endócrinas e metabólicas predisponentes ao aparecimento e desenvolvimento de doenças cardiovasculares 1-3 . Indivíduos com

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Body fat distribution in men with angiographically confirmed coronary artery disease

Cited by 48 publications

References 25 publications

Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

Obesity, body fat distribution and coronary atherosclerosis among Japanese men and women

Distribuição de gordura corporal, pressão arterial e níveis de lipídios-lipoproteínas plasmáticas

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