Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

Hoefle, G.; Saely, Christoph H.; Aczél, S.; Benzer, Werner; Marte, Thomas; Langer, Peter; Drexel, Heinz

doi:10.1038/sj.ijo.0802985

Cited by 44 publications

(31 citation statements)

References 30 publications

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“…In particular, WHR is considered the traditional anthropometric technique for assessing CFM-to-PFM ratio (12). It is widely used and established in cross-sectional (35), longitudinal (36) and intervention studies, and it is a robust predictor of disease risk and mortality (35,37,38). In this context, WHR, rather than BMI, has therefore recently been recommended for the assessment of body fatness (38).…”

Section: Discussionmentioning

confidence: 99%

Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults

Ketel

Volman

Seidell³

et al. 2007

eur j endocrinol

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Objective: To determine which anthropometric measurement is the most reliable alternative for fat distribution as measured by dual-energy X-ray absorptiometry (DXA). Design: Population-based survey carried out in Amsterdam, The Netherlands. Subjects and methods: A total of 376 individuals (200 women) with a mean age of 36.5 years and mean body mass index (BMI) of 24.0 (G3.1) kg/m 2 underwent various anthropometric and DXA measurements of central (CFM) and peripheral fat mass (PFM). Furthermore, for the assessment of apple-shaped body composition, CFM-to-PFM ratio was calculated. Anthropometric measurements were waist and hip circumference, waist-to-hip ratio (WHR), BMI, waist/length and the skinfold thickness of biceps, triceps, suprailiacal (SI), subscapular (SS) and upper leg. We determined whether equations of combined anthropometrics were even more reliable for the assessment of fat mass. Results: In both women and men, reliable alternatives for CFM are central skinfolds and waist (Pearson's correlation (r) R0.8). Peripheral skinfolds are the best predictors of PFM (rR0.8). In contrast, WHR correlated only marginally with any of the DXA measurements. Equations based on several anthropometric variables correlate with CFM even better (R 2 R0.8). CFM-to-PFM ratio has the highest correlation with the ratio (SSCSI)/BMI in women (rZ0.66) and waist/length in men (rZ 0.71). Equations are reasonable alternatives of CFM-to-PFM ratio (R 2 R0.5). Conclusion: Waist and skinfolds are reliable alternatives for the measurement of body fat mass in a cohort of Caucasian adults. WHR is not appropriate for the measurement of fat distribution.European Journal of Endocrinology 156 655-661

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Section: Discussionmentioning

confidence: 99%

Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults

Ketel

Volman

Seidell³

et al. 2007

eur j endocrinol

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“…However, only central obesity is significantly and independently predictive of the 2-year vascular mortality in coronary patients. 20 Furthermore, it has been suggested that WC is a better measurement of central obesity than waist-hip ratio, 21 and it has been posited that WC is more closely correlated with an atherogenic lipid profile than waist-hip ratio. 22 Similarly, our study finds the mean values of TG and FBG and the mean values for abnormal metabolic parameters in the COG to be higher than in the GOG.…”

Section: Discussionmentioning

confidence: 99%

Different Waist Circumferences, Different Metabolic Risks in Koreans

Joo¹,

Kim²,

Park³

et al. 2007

The Journal of the American Board of Family Medicine

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Objective: We investigated the difference in metabolic parameters by waist circumference (WC) and body mass index (BMI) in a population of Korean men and women.Method: We collected data on 69,535 Korean men and women and performed a cross-sectional analysis of the data. Study subjects were grouped by BMI and WC. We measured metabolic parameters for each group and compared the differences in the metabolic abnormalities. Subjects were grouped as follows: normal group (NG; normal WC and normal BMI); centrally obese group (COG; high WC and normal BMI); generally obese group (GOG; normal WC and high BMI); and combined obese group (COM; high WC and high BMI).Results: Subjects in the COM group showed more metabolic parameter abnormalities in comparison to the other groups. In men, triglyceride (TG) and fasting blood glucose (FBG) levels were higher in the COG than in the GOG. Correspondingly, total cholesterol (TC), TG, and FBG levels were higher in the female COG than in the female GOG. In addition, the mean numbers of abnormal metabolic parameters in the COG were higher than in the GOG for both men and women. More men and women developed metabolic syndrome in the COG (39.1% in men, 33.0% in women) than in the GOG (9.7% in men, 7.8% in women).Conclusion: Among Koreans, the COG had more metabolic abnormalities and metabolic syndrome than the GOG.

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“…A prospective study in a consecutive series of 756 men or women undergoing coronary angiography evaluated the prognostic significance of abdominal obesity (waist circumference or waist-hip ratio) and BMI, with regard to clinical outcomes. 43 BMI did not correlate significantly with the incidence of vascular or all-cause mortality, or the incidence of major coronary events during an average of 2.2 years of prospective follow-up. In contrast, waist circumference correlated significantly with vascular mortality in men (OR adjusted for age smoking and cholesterol [2.3 (95% CI 1.2-4.6), P ¼ 0.017] and women [8.7 (95% CI 1.8-42.7), P ¼ 0.008], with similar results for waist-hip ratio.…”

Section: Abdominal Obesitymentioning

confidence: 99%

Abdominal obesity, insulin resistance, and cardiovascular risk in pre-diabetes and type 2 diabetes

Haffner

2006

European Heart Journal Supplements

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Cardiovascular (CV) disease remains the leading source of premature mortality in western populations. There is an increasing prevalence of obesity, particularly abdominal obesity. Nine states in the USA now report a prevalence of obesity [body mass index (BMI) .30 kg/m 2 ] of 25% or more, and the prevalence of abdominal obesity (waist circumference .102 cm for men and 88 cm for women) has increased by 20% in men and 14% in women in a single decade. The intra-abdominal adiposity associated with abdominal obesity increases cardiometabolic risk directly, via altered secretion of adipokines, and indirectly, via promotion insulin resistance, diabetes and the cluster of cardiometabolic risk factors associated with the metabolic syndrome. Patients with type 2 diabetes, or subjects with pre-diabetic dysglycaemia are at greater risk of CV events, compared with normoglycaemic subjects. A large and growing body of evidence indicates that abdominal obesity is a more powerful predictor of adverse CV outcomes than BMI. Measurement of waist circumference as an index of intra-abdominal adiposity should be included in routine evaluations of overall cardiometabolic risk.

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Impact of total and central obesity on vascular mortality in patients undergoing coronary angiography

Cited by 44 publications

References 30 publications

Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults

Superiority of skinfold measurements and waist over waist-to-hip ratio for determination of body fat distribution in a population-based cohort of Caucasian Dutch adults

Different Waist Circumferences, Different Metabolic Risks in Koreans

Abdominal obesity, insulin resistance, and cardiovascular risk in pre-diabetes and type 2 diabetes

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