Body Fat Distribution and Uterine Leiomyomas

Sato, Fumio; Nishi, Motoi; Kudo, Ryuichi; Miyake, Hirotsugu

doi:10.2188/jea.8.176

Cited by 59 publications

(52 citation statements)

References 16 publications

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“…Coexistence of hypertension with UL has been documented in several small studies (10,(16)(17)(18)(19)(20). Boynton-Jarrett et al (11) has reported the first prospective data demonstrating a dose response relation between diastolic blood pressure and fibroid incidence, with higher blood pressure associated with higher fibroid risk.…”

Section: Discussionmentioning

confidence: 99%

“…Boynton-Jarrett et al (11) has reported the first prospective data demonstrating a dose response relation between diastolic blood pressure and fibroid incidence, with higher blood pressure associated with higher fibroid risk. The association of UL with hypertension has been explained partially by the reverse-causality interpretation suggesting that UL may cause hypertension as a consequence of urinary tract obstruction by large tumors (10,20). Another explanation has been made by the reninangiotensin system, which is implicated in the pathogenesis of hypertension (21)(22)(23).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of Cardiovascular Risk Factors in Women with Uterine Leimyomata: Is there a Link with Atherosclerosis?

Sivri¹,

Yalta²,

Sayın³

et al. 2012

Balkan Med J

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Objective: Both uterine leimyoma (UL) and cardiovascular disease are public health problems affecting women at different age ranges. Smoking, obesity, and hypertension have been shown to be associated with UL in different random studies. However cardiovascular risk factors have not been evaluated systematically in patients with UL. Accordingly, we aimed to evaluate the cardiovascular risk factors and their relation with the presence of UL.Material and Methods: One hundred and eighty nine patients with the pathological diagnosis of UL and one hundred and eighty nine age matched control subjects without UL were retrospectively included in the study from our data base of the pathology and gynecology departments. Controls were patients with intact uteri who had visited the same physicians for a routine checkup that included a pelvic examination and uterine sonogram and without mention of physical findings consistent with UL. The following clinical and demographic parameters were recorded; age, sex, hypertension, diabetes mellitus, and hypercholesterolemia. Current cigarette smoking was defined as active smoking within the past 12 months. Results:Comparison of cardiovascular risk factors between with and without UL revealed that the presence of hypertension (80 (42.3%) vs 53 (28%) p=0.004) diabetes mellitus (33 (17.4%) vs. 16 (8.4%) p=0.009), smoking (31 (16.4%) vs. 11 (5.8%) p=0.001), were significantly higher in patients with UL than in control subjects. The mean-age and presence of hyperlipidemia were comparable between the two groups. Logistic regression analysis revealed an independent and positive association of UL with the presence of hypertension (odds ratio 2.02 CI: 1.25-3.27 p=0.004), diabetes mellitus (odds ratio 2.43 CI: 1.23-4.79 p=0.010), and smoking status (odds ratio 3.46 CI: 1.65-7.22 p=0.001). Conclusion:We have shown that major cardiovascular risk factors namely, hypertension, diabetes mellitus and smoking are significantly and independently associated with UL. Our findings highlight the possible association of UL with atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiovascular Risk Factors in Women with Uterine Leimyomata: Is there a Link with Atherosclerosis?

Sivri¹,

Yalta²,

Sayın³

et al. 2012

Balkan Med J

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“…Similarly, a large prospective study of registered nurses in the United States (Marshall et al 1998b) found an increased fibroid risk with increasing adult BMI, as well as an increased risk associated with weight gain since age 18 years. A case-control study from Japan (Sato et al 1998) likewise reported that women with occult obesity (BMI < 24.0 and percent body fat ≥ 30%) or women with upper-body fat distribution (> 0.80 waist-tohip ratio) were at significantly higher risk. In a study from Boston, Massachusetts (Shikora et al 1991), 51% of the hysterectomy-or myomectomy-confirmed patients with leiomyomata were overweight, and 16% were severely obese; the authors compared their patients with a national study group of women in the United States included in The National Health and Nutrition Survey (Abraham and Johnson 1980;Flegal et al 1998;Van Itallie 1985), quoting comparison figures of 25% overweight and 7.2% severely obese.…”

Section: Obesitymentioning

confidence: 97%

Etiology and pathogenesis of uterine leiomyomas: a review.

Flake

Andersen

Dixon

2003

Environ Health Perspect

494

392

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Uterine leiomyomas, or fibroids, represent a major public health problem. It is believed that these tumors develop in the majority of American women and become symptomatic in one-third of these women. They are the most frequent indication for hysterectomy in the United States. Although the initiator or initiators of fibroids are unknown, several predisposing factors have been identified, including age (late reproductive years), African-American ethnicity, nulliparity, and obesity. Nonrandom cytogenetic abnormalities have been found in about 40% of tumors examined. Estrogen and progesterone are recognized as promoters of tumor growth, and the potential role of environmental estrogens has only recently been explored. Growth factors with mitogenic activity, such as transforming growth factor-β 3, basic fibroblast growth factor, epidermal growth factor, and insulin-like growth factor-I, are elevated in fibroids and may be the effectors of estrogen and progesterone promotion. These data offer clues to the etiology and pathogenesis of this common condition, which we have analyzed and summarized in this review.

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“…Nevertheless, the results of the studies about the correlation of myoma uteri and BMI are controversial. 1,8,9 Besides, as we know, there is not any study in literature which investigates the relationship of body fat distribution and insulin resistance with myoma uteri formation.…”

Section: Introductionmentioning

confidence: 99%