Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain

Yang, Shi Cheng; Lu, Li Fang; Cai, Ying; Zhu, Jia Bi; Liang, Bing; Yang, Chang Zheng

doi:10.1016/s0168-3659(99)00007-3

Cited by 422 publications

(188 citation statements)

References 22 publications

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“…In vitro ZMT release profile of selected nanoparticles was determined using dialysis membrane in USP II dissolution apparatus (Yang et al, 1999). The nanoparticles were kept in dialysis membrane-150 with a molecular weight cut-off of range of 12 -14 kDa (Hi-Media, Mumbai, India) and tied with rotating paddle at 100 rpm.…”

Section: In-vitro Drug Release Studiesmentioning

confidence: 99%

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Mandlik

Ranpise

2017

Int Curr Pharm J

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The present study investigated the implementation of 32 factorial design of experiment and statistical analysis for the optimization of chitosan nanoparticles containing zolmitriptan an antimigraine drug. The influence of chitosan concentration (X1) and sodium tripoly phosphate (X2) on responses namely nanoparticle size (Y1), and entrapment efficiency (Y2), was studied. As per design, nine runs of nanoparticles were prepared by modified ionic gelation method using high speed vortex mixing. The particle size was found in the range of 151-880 nm and entrapment efficiency was 72.3-81.2%. A statistical analysis was performed using licensed design expert software V.8.0 with respect to ANOVA, regression analysis. The contour plots and response surface plots showed visual representation of relationship between the experimental responses and the set of independent variables. Regression model equations were validated by a numerical and graphical optimization method. Further, optimized drug loaded nanoparticles showed +23.7mV zeta potential indicating storage stability, electron micrograph reflects spherical shape and mixed type of drug release followed by Fickian diffusion (n=0.266) was observed. Thus, using systematic factorial design approach, desirable goals can be achieved in shortest possible time with lesser number of experiments which was proven to be an effective tool in quality by design.Mandlik and Ranpise, International Current Pharmaceutical Journal, February 2017, 6(3): 16-22http://www.icpjonline.com/documents/Vol6Issue3/01.pdf

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Section: In-vitro Drug Release Studiesmentioning

confidence: 99%

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Mandlik

Ranpise

2017

Int Curr Pharm J

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“…Tumour targetinghas been achieved with SLNs loaded with drugs like methotrexate [23] and Camptothecin [24].Tamoxifen an anticancer drug is incorporated inSLN to prolong release of drug after i.v.…”

Section: Slns As a Targeted Carrier For Anticancer Drugto Solid Tumorsmentioning

confidence: 99%

Solid Lipid Nanoparticle: A Review

Joshi¹

2012

iosrphr

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“…In vitro release profile of MFA from formulations was determined using the dialysis bag technique (Sigma, USA; MWCO 12000-14000) (Yang et al, 1999). Because of the low solubility of MFA in water and acetate buffer (pH 6.0), acetate buffer (pH 6.0) with 1% w/v cetyltrimethylammonium bromide (CTAB) was selected as acceptor medium.…”

Section: In Vitro Releasementioning

confidence: 99%

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

Khurana

Bedi

Jain

2012

IJBNN

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This study was aimed to develop nanostructured lipid carriers (NLC) for the possible delivery of mefenamic acid. This study describes the effect of liquid lipid concentration on the characteristics of NLC such as particle size, polydispersity index, zeta potential, drug entrapment efficiency, and occlusivity index. Transmission electron microscopy revealed nearly spherical shape NLC with negligible effect of liquid lipid content on the particle morphology. The differential scanning calorimetry demonstrated a depression in the melting point and crystallinity index of the NLC with an increase in the amount of liquid lipid. The in vitro drug release studies demonstrated that solid lipid nanoparticle (0% oil), and NLC possessed a biphasic release pattern characterised by a rapid initial release followed by a sustained release, in comparison to nanoemulsions (100% oil) of which a nearly constant release was observed. Compared to NE and SLN, the excellent physical stability of NLC against drug leakage was seen.

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Body distribution in mice of intravenously injected camptothecin solid lipid nanoparticles and targeting effect on brain

Cited by 422 publications

References 22 publications

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Implementation of experimental design methodology in preparation and characterization of zolmitriptan loaded chitosan nanoparticles

Solid Lipid Nanoparticle: A Review

Development of nanostructured lipid carriers for controlled delivery of mefenamic acid

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