Body disappearance and liver mean transit time of 99m-Tc-diethyl-IDA

Abstract

The body disappearances and the liver mean transit times of a hepatobiliary tracer, 99mTc-diethyl IDA, were measured from 100 cholescintigraphies of 98 patients. Fifteen patients had no hepatobiliary disease; their mean body disappearance was 6.6, SD 1.1%/min, and mean liver mean transit time 32, SD 19 min. The values within 2 SDs, disappearance greater than or equal to 4.4%/min and mean transit time less than or equal to 70 min, were used as reference values. Disappearance constants below 4.4%/min were observed 29% and mean transit times exceeding 70 min in 49% of the examinations performed on patients with some hepatobiliary abnormality. The calculated parameters were compared with the levels of serum bilirubin and ASAT. Disappearance constants below 4.4%/min were seen in 33% and mean transit times exceeding 70 min in 55% of the patients who had either abnormal serum bilirubin or ASAT due to a hepatobiliary disease. The correlation between the serum bilirubin and the disappearance was -0.13, and between ASAT and body disappearance it was -0.28. The corresponding correlation coefficients of serum bilirubin and ASAT with the liver mean transit times were 0.33 and 0.44. Long mean transit times in relation to bilirubin and ASAT were seen in some acute cases. Short mean transit times in relation to bilirubin and ASAT were seen with falling serum levels of the latter.

ICRP Publication 128: Radiation Dose to Patients from Radiopharmaceuticals: a Compendium of Current Information Related to Frequently Used Substances

“…Typical examples are a large group of technetium-labelled iminodiacetic acid (IDA) derivatives (e.g. BIDA, HIDA, EIDA, PIPIDA, PBIDA, and DISIDA). (A31) Several biokinetic models have been presented in the literature for technetium-labelled IDA derivatives (Ryan et al., 1977; Wistow et al., 1977; Taavitsainen et al., 1980; Brown et al., 1981, 1982; Wu et al., 1984). The substance is assumed to be taken up rapidly in the liver from the blood and then excreted, via the biliary tract, partly to the gallbladder for temporary storage and partly to the intestine.…”

Annexes A and B

“…(A 31) This model is intended for substances that are actively taken up in hepatocytes and excreted, via the biliary tract, to the intestine. Typical examples are a large (Ryan et al, 1977;Wistow et al, 1977;Taavitsainen et al, 1980;Brown et al, 1981Brown et al, , 1982Wu et al, 1984). The substance is assumed to be rapidly taken up in the liver from the blood and then excreted, via the biliary tract, partly to the gallbladder for temporary storage and partly directly to the intestine.…”

The development of nuclear medicine in Finland: a review on the occasion of the 40th anniversary of the Finnish Society of Nuclear Medicine

“…The effects of platelet auto‐antibodies on the kinetics of 111 In‐labelled auto‐ and homologous platelets in patients with idiopathic thrombocytopenic purpura were studied (Savolainen et al ., 1992). Over the years radioisotopic procedures have also been applied to research in cardiology (Heiskanen, 1971; Korhola, 1974), gastroenterology (Taavitsainen et al ., 1980) and particularly nephrology and urology (Heiskanen et al ., 1968; Tamminen et al ., 1978; Lindell et al ., 1986; Helin et al . 2000).…”