Body composition in lean women with polycystic ovary syndrome: effect of ethinyl estradiol and drospirenone combination

Aydín, Kadriye; Çınar, Neşe; Aksoy, Duygu Yazgan; Bozdağ, Gürkan; Yildiz, Bülent O.

doi:10.1016/j.contraception.2012.07.005

Cited by 50 publications

(55 citation statements)

References 21 publications

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“…Furthermore, Attlee et al [11] used BIA analysis to discover that FFM and percentage of adipose tissue did not significantly differ between young females with and without PCOS. This finding expands on other studies that did not find a difference between anthropometric measurements including weight, BMI, waist and hip circumference, in women with PCOS versus women without PCOS [12]. In turn, Ezeh et al [13] studied a group of adult female patients with PCOS and found an unfavorable body composition, characterized by an increased fat-to-muscle ratio.…”

Section: Currently On a Diet To Lose Weightsupporting

confidence: 82%

Body mass composition and dietary habits in adolescents with polycystic ovary syndrome

et al. 2019

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Objectives:The aim of the present study is to assess differences in body composition between female participants in the study group who suffer from PCOS versus a healthy control group. Material and methods:The study included 85, 14-22-year-old, female participants. Participants belonged to one of two groups. Thirty seven participants with a diagnosis of PCOS were in the clinical group, and 48 participants were in the healthy control group with no prior diagnosis of PCOS.Results: A statistically significant difference between groups was found in their answer regarding diet. A correlation was found between the body fat index and the use of dieting among participants; participants with a lower body fat index (in kilograms) were less likely to be on a diet. Conclusions:The young female participants with PCOS were shown to have similar body composition to age-matched healthy controls. However, the clinical group with PCOS reported more frequent use of dieting, with less use of exercise.

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Section: Currently On a Diet To Lose Weightsupporting

confidence: 82%

Body mass composition and dietary habits in adolescents with polycystic ovary syndrome

et al. 2019

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“…In women, fewer studies have been performed, and the results were not always consistent. It has been generally believed that androgen is positively correlated with total body fat content and involved in the menopause-related visceral fat accumulation111213. Some studies, however, found negative associations between circulating testosterone levels and visceral fat accumulation measured by ultrasound or computed tomography21.…”

Section: Discussionmentioning

confidence: 99%

“…Given the clinical associations described above, we found the gender-specific correlations of androgen with serum A-FABP levels to be similar to the relationships of androgen with the FM. Studies investigating the association of estrogen with the fat content and distribution, nevertheless, have produced inconsistent findings11121314. In addition, few clinical studies have evaluated the correlation between estrogen and serum A-FABP levels.…”

Section: Discussionmentioning

confidence: 99%

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Pan

Luo

et al. 2016

Sci Rep

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Clinical investigations have indicated women have higher levels of adipocyte fatty acid binding protein (A-FABP) than men. The present study aimed to identify factors related to gender difference in serum A-FABP levels. A total of 507 participants (194 men, 132 premenopausal women, and 181 postmenopausal women) were enrolled in the present study. Serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women in both body mass index categories (<25.0 and ≥25.0 kg/m2; all P < 0.05). Multiple stepwise regression analyses showed that after adjustment for factors related to serum A-FABP levels, the trunk fat mass was an independent and positive factor of serum A-FABP levels. For men, total testosterone was associated independently and inversely with serum A-FABP levels. For pre- and postmenopausal women, bioavailable testosterone and total testosterone were independent and positive factors associated with serum A-FABP levels, respectively. The present study demonstrated that the androgen was correlated with the serum A-FABP levels negatively in men, but positively in women. With these effects on the fat content, especially trunk fat, androgen might contribute to the gender difference in serum A-FABP levels.

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“…The following contrasting results were also published; (1) Kirschengast and Hubert reported that half their lean PCOS patients had android fat distribution and all lean controls were gynoid (Kirschengast 2001), (2) Carmina et al (2007) Yildirim et al (2003) demonstrated that the mean pre-peritoneal and visceral fat layer determined by ultrasound in nonobese PCOS patients with BMI<25 kg/m² was significantly greater than in controls, (4) Puder et al (2005) accorded that the trunk to extremity fat ratio was higher in PCOS women (BMI=26.3±5.7 kg/m²) compared to controls (BMI=25.5±4.8 kg/m²) (1.06 vs. 0.79, p=0.007), (5) Yucel et al (2005) showed that fat mass in the trunk and arms and the ratio of trunk fat mass to leg fat mass was significantly higher in non-obese patients with PCOS (p<0.05): (6) A Swedish study reported that lean PCOS women with mean BMI 23±1.5 kg/m² had significantly higher trunk to peripheral fat ratio (Svendsen et al 2008), (7) Good et al(1999) found no statistically significant differences in body fat distribution in lean PCOS women and controls; although the former tended to have lower mean body fat percentages, and (8) most recently, Aydin et al (2013) documented no differences in fat distribution in lean PCOS women and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Body composition of lean women with polycystic ovary syndrome

Zabulienė

Urbonienė

Tutkuvienė

2013

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Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine and metabolic disorders in reproductive age women, and it is related to changes in body size, shape and composition. Anthropometric somatotype is a quantitative description of the individual's body shape and composition classified as endomorphy, mesomorphy or ectomorphy. Since PCOS somatotype has never previously been studied, here we evaluate body shape and composition phenomena in lean women with polycystic ovary syndrome and assess relationships with metabolic parameters. The study of 20-35 year-old women was carried out at the Department of Anatomy, Histology and Anthropology at Vilnius University. Standard anthropometric instruments and methods were used, and J. Matiegka's equations calculated skeletal mass, skin and subcutaneous adipose tissue and muscles and internal organs. In addition, Heath -Carter's somatotypes were computed, and the participants' glucose, insulin, testosterone, sex hormone-binding globulin and lipid levels were established. We analysed data from 120 women with a mean age of 27.30 ± 3.68 years. Lean women with PCOS had greater skeletal mass by 0.47 kg (p<0.05, Cohen's d=1.14), greater skin and subcutaneous adipose tissue mass by 2.79 kg (p<0.05, Cohen's d=6.07) and lower muscle mass by 1.47 kg (p<0.05, Cohen's d=2.84) compared to control women (p<0.05). The mean PCOS somatotype ratio was 4.96-4.38-3.00 (SD 1.50-1.26-1.11). This classified women with PCOS as mesomorphic endomorphs, in contrast to healthy women who were endomorphic mesomorphs. The PCOS subjects' skin and subcutaneous adipose tissue and endomorphy/mesomorphy somatotype positively correlated with insulin levels and the HOMA-IR. It was established that lean women with polycystic ovary syndrome had a mesomorphic endomorph somatotype and higher skin and subcutaneous adipose tissue mass, but less muscle mass than healthy lean women. In addition, skin and subcutaneous adipose tissue positively correlated with insulin level and HOMA-IR in lean PCOS women.

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Body composition in lean women with polycystic ovary syndrome: effect of ethinyl estradiol and drospirenone combination

Cited by 50 publications

References 21 publications

Body mass composition and dietary habits in adolescents with polycystic ovary syndrome

Body mass composition and dietary habits in adolescents with polycystic ovary syndrome

Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Body composition of lean women with polycystic ovary syndrome

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