Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Hu, Xiang; Pan, Xiaoping; Luo, Yuqi; Xu, Yiting; Xiong, Qian; Bao, Yuqian; Jia, Weiping

doi:10.1038/srep27762

Cited by 13 publications

(17 citation statements)

References 33 publications

(61 reference statements)

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“…Furthermore, the effects of testosterone vary with the different active forms related to sex hormone-binding globulin between premenopausal women and postmenopausal women. 17 Consistent with these findings, the present study confirmed that the serum A-FABP levels increased in the order from men to premenopausal women to postmenopausal women, suggesting that the gender- and menopause-related differences in serum A-FABP levels should be taken into consideration when A-FABP was used as a serum biomarker.…”

Section: Discussionsupporting

confidence: 90%

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Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution

Pan

et al. 2016

Int J Obes

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Background/Objectives:First-degree relatives of patients with diabetes bear an increased risk of diabetes, overweight/obesity and cardiovascular disease. Accumulating evidence indicates that circulating concentrations of adipokines are altered in individuals with a first-degree family history of diabetes (FHD), but the adipokine adipocyte fatty acid binding protein (A-FABP) has been rarely studied in this population. The present study explored the association between a first-degree FHD and serum A-FABP levels.Subjects/Methods:A total of 1962 normoglycemic participants were divided into subgroups of men, premenopausal women and postmenopausal women. Serum A-FABP levels were measured using a sandwich enzyme-linked immunoabsorbent assay. Abdominal fat distribution, including visceral fat area and subcutaneous fat area, was assessed by magnetic resonance imaging.Results:Totals of 792 men, 544 premenopausal women and 626 postmenopausal women were enrolled. Serum A-FABP levels were much higher in subjects with a first-degree FHD than in those without an FHD in all subgroups (all P<0.05). Logistic regression analysis revealed an independent and positive relationship between a first-degree FHD and serum A-FABP levels in men (P=0.029), premenopausal women (P=0.036) and postmenopausal women (P=0.008). Multiple stepwise regression analysis showed that a first-degree FHD was an independent factor positively associated with serum A-FABP levels in men (standardized β=0.068, P=0.029), premenopausal women (standardized β=0.090, P=0.018) and postmenopausal women (standardized β=0.102, P=0.004).Conclusions:Serum A-FABP levels were increased significantly in normoglycemic individuals with a first-degree FHD. The contribution of the first-degree FHD to the elevated serum A-FABP levels was independent of total body fat content and abdominal fat distribution. Thus, use of serum A-FABP as a biomarker in the first-degree relatives of patients with diabetes may result in overestimation of the risk of obesity-induced metabolic disease and cardiovascular disease.

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Section: Discussionsupporting

confidence: 90%

“…4 Owing to gender differences in serum A-FABP levels observed in our previous study, 17 the present study divided the study population into subgroups of men, premenopausal women and postmenopausal women for analysis.…”

Section: Methodsmentioning

confidence: 96%

Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution

Pan

et al. 2016

Int J Obes

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“…FABP4 level is significantly higher in females than in males, possibly due to the larger amount of body fat in females than in males since there is an independent and strong correlation between FABP4 level and adiposity 70, 71) . In addition, androgen may partially contribute to the gender difference in serum FABP4 levels 72) . Circulating FABP4 levels are significantly correlated with norepinephrine levels during exercise testing 73) , being consistent with FABP4 secretion from adipocytes via β -adrenergic-mediated lipolytic mechanisms 54–56) .…”

Section: Circulating Fabp4 Levelmentioning

confidence: 99%

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Furuhashi

2019

JAT

186

172

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The official journal of the Japan Atherosclerosis Society and the Asian Pacific Society of Atherosclerosis and Vascular Diseases Review Fatty acid-binding proteins (FABPs), a family of lipid chaperones, contribute to systemic metabolic regulation via several lipid signaling pathways. Fatty acid-binding protein 4 (FABP4), known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays important roles in the development of insulin resistance and atherosclerosis in relation to metabolically driven low-grade and chronic inflammation, referred to as 'metaflammation'. FABP4 is secreted from adipocytes in a non-classical pathway associated with lipolysis and acts as an adipokine for the development of insulin resistance and atherosclerosis. Circulating FABP4 levels are associated with several aspects of metabolic syndrome and cardiovascular disease. Ectopic expression and function of FABP4 in cells and tissues are also related to the pathogenesis of several diseases. Pharmacological modification of FABP4 function by specific inhibitors, neutralizing antibodies or antagonists of unidentified receptors would be novel therapeutic strategies for several diseases, including obesity, diabetes mellitus, atherosclerosis and cardiovascular disease. Significant roles of FABP4 as a lipid chaperone in physiological and pathophysiological conditions and the possibility of FABP4 being a therapeutic target for metabolic and cardiovascular diseases are discussed in this review. Fatty Acid-Binding Proteins (FABPs) Fatty acid trafficking in cells affects many aspects of cellular function 3). Fatty acids act both as an energy source and as signals for metabolic regulations including gene expression, inflammatory and metabolic responses, and growth and survival pathways. Fatty acid-binding proteins (FABPs), a family of intracellular lipid chaperones, regulate lipid trafficking and responses in cells and are linked to metabolic and inflammatory pathways 3-6). FABPs are abundantly expressed 14-15-kDa proteins that reversibly bind hydrophobic ligands, such as long-chain fatty acids and other lipids. It has been proposed that FABPs actively facilitate the transport of fatty acids to specific organelles in the cell for lipid oxidation in the mitochondrion or peroxisome, transcriptional regulation in the nucleus, signaling, trafficking and membrane synthesis in the endoplasmic reticulum (ER), and regula-Copyright©2019 Japan Atherosclerosis Society This article is distributed under the terms of the latest version of CC BY-NC-SA defined by the Creative Commons Attribution License.

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“…Greater age and female gender were both also associated with higher baseline FABP4. Factors accounting for gender differences include androgen hormone production and body composition 44 .…”

Section: Discussionmentioning

confidence: 99%

Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management

Jahansouz

Kizy

et al. 2019

Surgery

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Background: Serum concentrations of fatty acid binding proteins 4 (FABP4), an adipose tissue fatty acid chaperone, have been correlated with insulin resistance and cardiovascular risk factors. The objective of this study are to: (1) To assess relationships between Roux-en-Y gastric bypass (RYGB), intensive lifestyle modification and medical management protocol (LS/IMM), FABP4, and metabolic parameters in obese patients with severe type 2 diabetes mellitus (T2DM). (2) To evaluate the relative contribution of abdominal subcutaneous adipose and visceral adipose to the secretion of FABP4. Methods: Subjects were randomized to LS/IMM (n = 29) or to LS/IMM augmented with RYGB (n = 34). Relationships between FABP4 versus demographics, metabolic parameters, and 12month changes in these values were examined. Visceral and subcutaneous adipose tissue explants from obese non-diabetic patients (n=5) were obtained and treated with forskolin to evaluate relative secretion of FABP4 in the different adipose tissue depots.

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Association of androgen with gender difference in serum adipocyte fatty acid binding protein levels

Cited by 13 publications

References 33 publications

Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution

Contribution of a first-degree family history of diabetes to increased serum adipocyte fatty acid binding protein levels independent of body fat content and distribution

Fatty Acid-Binding Protein 4 in Cardiovascular and Metabolic Diseases

Serum FABP4 concentrations decrease after Roux-en-Y gastric bypass but not after intensive medical management

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