Body composition in hypopituitary dwarfs before and during human growth hormone therapy

Parra, Adalberto; Argote, Rosa Ma.; García, Guadalupe; Cervantes, C. Escobar; Alatorre, S.; Pérez-Pastén, E

doi:10.1016/0026-0495(79)90212-9

Cited by 89 publications

(45 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The young and old Little mice in this study had significantly decreased body weights (45% and 40% lower, respectively) compared with their respective age-matched WT littermates. This is in agreement with the reduction in body weight reported in animals (6,(22)(23)(24)(25) and in humans (26,27), specifically in humans with familial dwarfism whose body weights were significantly lower than normal participants (16). However, the relative increase in body weight with age in the Little mice is similar to their WT counterparts much like the ageassociated weight gain in humans (28).…”

Section: Body Weightsupporting

confidence: 80%

Young Little Mice Express a Premature Cardiovascular Aging Phenotype

Reddy

Hartley

Pham

et al. 2013

The Journals of Gerontology Series A: Biological Sciences and M

View full text Add to dashboard Cite

To investigate the effect of growth hormone and insulin-like growth factor 1 deficiency on the aging mouse arterial system, we compared the hemodynamics in young (4 months) and old (30 months) growth hormone-releasing hormone receptor null dwarf (Little) mice and their wild-type littermates. Young Little mice had significantly lower peak and mean aortic velocity and significantly higher aortic impedance than young wild-type mice. However, unlike the wild-type mice, there were no significant changes in arterial function with age in the Little mice. Aortic pulse wave velocity estimated using characteristic impedance increased with age in the wild-type mice, but it changed minimally in the Little mouse. We therefore conclude that arterial function in Little mice expresses a premature aging phenotype at young age and may neither enhance nor reduce their longevity.

show abstract

Section: Body Weightsupporting

confidence: 80%

Young Little Mice Express a Premature Cardiovascular Aging Phenotype

Reddy

Hartley

Pham

et al. 2013

The Journals of Gerontology Series A: Biological Sciences and M

View full text Add to dashboard Cite

show abstract

“…The latter gain special importance as clinical trials are presently underway evaluating GH effects in normal children, in catabolic patients and in aging. These distinctions may explain the apparent discrepancies between different reports on the incidence and severity of water retention under GH therapy and its mechanism [6, 8, 9]. In both adults and childhood GHD total body water is reduced, as are lean body mass, extracellular and intracellular water [5, 8].…”

Section: Discussionmentioning

confidence: 59%

“…These distinctions may explain the apparent discrepancies between different reports on the incidence and severity of water retention under GH therapy and its mechanism [6, 8, 9]. In both adults and childhood GHD total body water is reduced, as are lean body mass, extracellular and intracellular water [5, 8]. The chronicity of the disease and its inherent hypovolemia may alter regulatory mechanisms, to be affected by GH replacement.…”

Section: Discussionmentioning

confidence: 66%

“…First, there is a difference between adult subjects and children. Children are reported to have a milder effect of GH on water balance [7, 8, 9, 10]. Secondly, there are two separate phenomena in terms of the time course: a short term, transient, mild response and a prolonged clinical entity of edema, arthralgia and sometimes hypertension [5, 6].…”

Section: Discussionmentioning

confidence: 99%

“…In childhood GHD, weight gain, peripheral edema and hypertension during GH therapy have been reported only in single cases, and were mild with no increase in serum aldosterone [7, 8]. Reports on GH administration to normal short children range from no changes in water and sodium retention [9] to mild and transient hypertension, with an insignificant increase in body weight and no change in PRA or aldosterone levels [10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Water and Sodium Retention during Short-Term Administration of Growth Hormone to Short Normal Children

1998

View full text Add to dashboard Cite

GH treatment of adult patients with GH deficiency (GHD) or healthy volunteers results in weight gain and fluid and sodium retention. In the present study we have challenged normal short children with dehydration and water load, and evaluated their water and sodium clearance, plasma renin activity (PRA) and aldosterone over 4 weeks of GH administration. Eleven prepubertal short normal children, aged 4–9 years, were the subjects of this study. Recombinant GH was administered daily at a dose of 2.5 units/m². Dehydration and water load experiments were conducted before GH (day 0) and on days 3, 7 or 28 of GH. An initial 15-hour fast ended with a 3-hour urine collection. A tap-water load of 800 ml/m² was given orally. Urinary volumes were followed hourly for 3 h, as were urinary and serum creatinine, Na, K, aldosterone, plasma osmolality and PRA. Before GH therapy the subjects excreted within 2 h a mean 42% and within 3 h a mean 65% of the load. After 3 days of GH therapy the same children retained water significantly and excreted only 22 (p < 0.02) and 45% (p < 0.05) of the load volume, respectively. Calculating the free water clearance revealed no effect of GH therapy, whereas the fractional excretion of sodium and potassium decreased significantly by day 3 of GH administration, along with an increase in PRA and serum aldosterone. All these changes normalized by days 7 and 28 of GH therapy. It is concluded that short-term administration of GH to short normal children results in a transitory mild retention of sodium and a secondary water retention, and suggests that the primary event leading to sodium retention during the early phase of GH therapy of short normal children is an inappropriate increase in PRA.

show abstract

Hormonal changes during puberty and their relationship to fat distribution

Roemmich

Rogol

1999

Am. J. Hum. Biol.

View full text Add to dashboard Cite

Body composition in hypopituitary dwarfs before and during human growth hormone therapy

Cited by 89 publications

References 18 publications

Young Little Mice Express a Premature Cardiovascular Aging Phenotype

Young Little Mice Express a Premature Cardiovascular Aging Phenotype

Water and Sodium Retention during Short-Term Administration of Growth Hormone to Short Normal Children

Hormonal changes during puberty and their relationship to fat distribution

Contact Info

Product

Resources

About