Body Composition in Children and Adolescents Born after<i>in Vitro</i>Fertilization or Spontaneous Conception

Ceelen, Manon; Weissenbruch, Mirjam M. van; Roos, Jan C.; Vermeiden, Jan P.W.; Leeuwen, Flora E. van; Waal, Henriëtte A. Delemarre-van de

doi:10.1210/jc.2006-2896

Cited by 168 publications

(143 citation statements)

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“…The data described in this paper were derived from a large study performed between March 2003 and March 2006 on the growth, health, and psychological functioning of IVF children born between 1986 and 1995 (see for more details of the study population Ceelen et al [5]). Families with a singleton child conceived by IVF conception in the VUmc, Amsterdam, the Netherlands, were invited by mail to participate in the study.…”

Section: Population and Participantsmentioning

confidence: 99%

School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

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The aim of this study was to examine the school functioning of 8-to 18-year-old children born after in vitro fertilization (IVF). We compared 233 children born after IVF to 233 matched control children born spontaneously from parents with fertility problems on measures of education level, general cognitive ability, school performance (need for extra help, repeating a grade, special education), and rates of learning and developmental disorders. No differences were found between IVF and control children on these measures of school functioning. More than 60% of adolescents at secondary school attended high academic levels (with access to high school or university). We conclude that children and adolescents born after IVF show good academic achievement and general cognitive ability. They do not experience any more educational limitations than the naturally conceived children and adolescents of the control group. The tendency of reassuring school functioning already found in younger IVF children has been shown to continue at secondary school age.

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Section: Population and Participantsmentioning

confidence: 99%

School functioning in 8- to 18-year-old children born after in vitro fertilization

et al. 2008

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“…The authors conclude that ART children display generalized vascular dysfunction and that these are related to the ARTprocedure [79,82].…”

Section: Norwegian Data On Art Children and Their Siblingsmentioning

confidence: 94%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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Purpose Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor. Methods Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE). Results Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry). Conclusion The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation. Capsule Remaining mindful of the growing body of evidence showing that during gamete production, genetic and epigenetic changes influence offspring health, serves to reinforce the need to continue to monitor ART children.

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“…IVF and ICSI are also suggested to change the early environment in such a manner that it may have long-term consequences for the offspring (21). Indeed, several studies suggested subtle cardiometabolic alterations in IVF/ICSI offspring (5,6,8,9). This was partly expected, as IVF and ICSI conceptions more often result in preterm birth and low birth weight, which are risk factors for adiposity and hypertension (22).…”

Section: Discussionmentioning

confidence: 99%

“…Little is known about the health outcome of children born following PGS. In this respect, it is noteworthy that recent reports indicated that IVF/ICSI by itself is associated with increased blood pressure (BP), altered body fat distribution, and vascular dysfunctions in offspring (5)(6)(7)(8)(9). Taking into account the general notion that the early environment shapes an individual's physical health later in life (10), it is conceivable that PGS, which includes more extensive embryo manipulation, introduces extra risks for adverse cardiometabolic outcome in offspring.…”

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confidence: 99%

Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial

et al. 2013

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Background: Recent studies suggest that in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) are associated with suboptimal cardiometabolic outcome in offspring. It is unknown whether preimplantation genetic screening (PGS), which involves embryo biopsy, affects blood pressure (BP), anthropometrics, and the frequency of received medical care. Methods: In this prospective multicenter follow-up study, we assessed BP, anthropometrics, and received medical care of 4-y-old children born to women who were randomly assigned to IVF/ICSI with PGS (n = 49) or without PGS (controls; n = 64). We applied linear and generalized linear mixed-effects models to investigate possible effects of PGS. results: BP in the PGS and control groups was similar: 102/64 and 100/64 mm Hg, respectively. Main anthropometric outcomes in the PGS vs. control group were: BMI: 16.1 vs. 15.8; triceps skinfold: 108 vs. 98 mm; and subscapular skinfold: 54 vs. 53 mm (all P values > 0.05). More PGS children than controls had received paramedical care (speech, physical, or occupational therapy: 14 (29%) vs. 9 (14%); P = 0.03 in multivariable analysis). The frequency of medicial treatment was comparable. conclusion: PGS does not seem to affect BP or anthropometrics in 4-y-old children. The higher frequency of received paramedical care after PGS may suggest an effect of PGS on subtle developmental parameters. W orldwide, the number of couples undergoing in vitro fertilization (IVF), with or without intracytoplasmic sperm injection (ICSI), is gradually increasing (1). Nevertheless, pregnancy rates after IVF/ICSI are lower than desired. To enhance efficiency of IVF/ICSI, new techniques such as preimplantation genetic screening (PGS) have been developed.In PGS, embryos are biopsied, and one or two blastomeres are aspirated and screened for aneuploidies. Only embryos with a normal chromosomal constitution are selected for transfer to the uterus (2). However, randomized controlled trials have indicated that PGS is not associated with higher pregnancy rates. As a matter of fact, reduced pregnancy rates after PGS are described for women of advanced maternal age (3,4). As a consequence, PGS is no longer recommended.Nevertheless, evaluation of the health of children born following PGS is relevant as it may reveal valuable information on long-term consequences of embryo biopsy. This is important as embryo biopsy is increasingly applied in the form of preimplantation genetic diagnosis (PGD). Little is known about the health outcome of children born following PGS. In this respect, it is noteworthy that recent reports indicated that IVF/ICSI by itself is associated with increased blood pressure (BP), altered body fat distribution, and vascular dysfunctions in offspring (5-9). Taking into account the general notion that the early environment shapes an individual's physical health later in life (10), it is conceivable that PGS, which includes more extensive embryo manipulation, introduces extra risks for adverse cardiometabolic outcome in offspring. T...

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Body Composition in Children and Adolescents Born afterin VitroFertilization or Spontaneous Conception

Abstract: Our observations indicate that body fat composition in IVF children is disturbed. Follow-up of IVF children to monitor body fat pattern and potentially related health problems from adolescence into adulthood is of great importance.

Cited by 168 publications

References 37 publications

School functioning in 8- to 18-year-old children born after in vitro fertilization

School functioning in 8- to 18-year-old children born after in vitro fertilization

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Blood pressure and anthropometrics of 4-y-old children born after preimplantation genetic screening: follow-up of a unique, moderately sized, randomized controlled trial

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