Body Composition Changes Following Sleeve Gastrectomy Vs. One-Anastomosis Gastric Bypass: Tehran Obesity Treatment Study (TOTS)

Barzin, Maryam; Almasi, Minoo Heidari; Mahdavi, Maryam; Khalaj, Alireza; Hosseinpanah, Farhad

doi:10.1007/s11695-021-05722-1

Cited by 11 publications

(7 citation statements)

References 25 publications

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“…The results of our study, as well as those of other authors, indicate that the reduction of body weight after LSG was caused not only by the reduction of total body fat mass, but also by the reduction of fat free mass [ 7 , 8 , 19 , 20 , 22 , 23 ]. Six months after the procedure, we proved a reduction in FM by 37.5% in the group of women and by 37.06% in the group of men, as well as a reduction in FFM by 10% in the group of women and by 12.5% in the group of men.…”

Section: Discussionsupporting

confidence: 85%

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Assessment of the Clinical Condition and Way of Patients’ Nutrition before and after Laparoscopic Sleeve Gastrectomy

Jastrzębska-Mierzyńska

Ostrowska

Witczak-Sawczuk

et al. 2023

Nutrients

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One of the most commonly performed bariatric procedures is the laparoscopic sleeve gastrectomy (LSG). It is highly effective in reducing body weight, but it carries the risk of developing nutritional deficiencies and their consequences. The aim of the study was to determine the clinical condition of obese patients after LSG in terms of nutritional status, metabolic disorders, and way of nutrition. Thirty participants (15 women and 15 men) took part in the study. A statistically significant reduction in the total body fat mass (women by 37.5% p < 0.05, men by 37.06% p < 0.05) and total fat free mass (women by 10% p < 0,05, men by 12.5% p < 0.05) was demonstrated 6 months after LSG. Moreover, insufficient protein intake has been shown in over 73% of women and 40% of men. Before and 6 months after LSG, insufficient intake of calcium, magnesium, potassium, folate, vitamin D, and iron was observed. Six months after the LSG, significant decreases of fasting glucose (p < 0.05), insulin (p < 0.05), TG (p < 0.05), and AST (p < 0.05) concentrations, were observed in both groups. Optimization of nutrition in order to prevent nutritional deficiencies and their complications is a key element of the therapy of obese patients treated surgically.

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Section: Discussionsupporting

confidence: 85%

“…In the study by Golzarand M. et al, the average EWL was higher and amounted to 66.4 ± 23.8% [ 19 ]. Similarly, in the study by Barzin M. et al, where EWL was 62.2 ± 15.7% [ 20 ]. On the other hand, the results published by Otto M. et al, indicate lower average EWL—39.1 ± 10.4% [ 21 ].…”

Section: Discussionmentioning

confidence: 57%

Assessment of the Clinical Condition and Way of Patients’ Nutrition before and after Laparoscopic Sleeve Gastrectomy

Jastrzębska-Mierzyńska

Ostrowska

Witczak-Sawczuk

et al. 2023

Nutrients

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“…Body fat distribution is highly associated with metabolic disorders; this was observed in a study by Ambrosi et al, who presented that irrespective of BMI or weight loss, the increase in body fat percentage after Roux-en-Y gastric bypass (RYGB) is associated with cardiometabolic risk factors [ 27 ]. Changes in body composition and weight loss were observed in two studies after LSG operation, which showed all decreased levels after the weight loss [ 17 , 18 ]. Luna et al [ 15 ] observed the same effect in RYGB patients; our study confirms this.…”

Section: Discussionmentioning

confidence: 99%

“…Changes in body composition and weight loss were also observed in a study by Otto in 2016, whereby LSG and RYGB did not differ in terms of body composition and weight loss 1 year after surgery [ 28 ]. Three studies [ 17 , 18 , 28 ] tested this in one group of patients who lost weight and not in a group with WR. Luna et al also tested that after 60 months of WR following RYGB, the body composition almost completely returned to that of the pre-operative obesity [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies compared across groups the body composition and metabolic biomarkers using analysis of variance revealed an effect size of 0.25, 0.30, and 0.35, slightly close to the large effect size of 0.4 that is predicted. [ 17 , 18 ] In this study, we conducted multiple linear regressions; therefore, a large effect size of 0.35 was used with a (1-β) power of 80% at α = 0.05, yielding a minimum sample size of 56.…”

Section: Methodsmentioning

confidence: 99%

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Effect of Weight Regain on Body Composition and Metabolic Biomarkers After Sleeve Gastrectomy: a Cross-Sectional Study from a Hospital Database

et al. 2022

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Introduction Weight regain (WR) is described in approximately 30% of patient’s post-bariatric surgery. It is related to the progression or recurrence of associated medical problems and decline in health-related quality of life. This study aimed to test the return of body composition and metabolic biomarkers to pre-operative levels when WR occurs. Methods In this cross-sectional study conducted in 2021, patients were randomly selected from the hospital’s electronic databases between 2001 and 2020. Patient demographic data, comorbidities, body compositions, and metabolic biomarkers were collected. Three groups were defined: groups A (WR), B (weight loss), and C (control group; patients with obesity who had not yet undergone bariatric surgery). Results A total of 88 patients were enrolled in this study and matched with the control group. The body mass index in group A was 43.8 ± 6.9 kg/m2; group B was 28.6 ± 4.2; group C was 43.9 ± 7.1. Body muscle mass, body fat mass, and visceral fat significantly differed between groups A and B (p < 0.001) but not between groups A and C (p = 0.8). There was a significant difference in leptin, ghrelin, postprandial glucagon-like peptide-1, insulin, and fibroblast growth factor-21 (but not retinol-binding protein-4) between groups A and B. Most metabolic biomarkers in group A returned to the pre-operative values as in group C. Conclusion WR had a direct negative effect on body composition and metabolic biomarkers, whereby the values returned to pre-operative levels. Early detection of WR and possible additional therapy are necessary to prevent associated medical problems. Graphical Abstract

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Comparing Effects of Bariatric Surgery on Body Composition Changes in Metabolically Healthy and Metabolically Unhealthy Severely Obese Patients: Tehran Obesity Treatment Study (TOTS)

et al. 2022

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Background Among two popular obesity phenotypes, metabolically healthy severely obese (MHSO) and metabolically unhealthy severely obese (MUSO), it is important to clarify whether or not those with MHSO phenotype would benefit from bariatric surgery in terms of an improvement in body composition parameters. Methods A prospective cohort was conducted on a total of 4028 participants (1404 MHSO and 2624 MUSO) who underwent bariatric surgery; MHSO was defined as having abnormalities in none or one of these four parameters: systolic blood pressure and/or diastolic blood pressure, triglycerides, fasting plasma glucose, and high‐density lipoprotein. Otherwise, the definition of MUSO was met. Body composition analysis was performed at the baseline and 6‐, 12‐, 24‐, and 36‐month post‐surgery using bioelectrical impedance analyzer. Results Both phenotypes showed a significant decrease in fat mass (FM) and fat‐free mass (FFM) and a significant increase in EWL% and TWL% (Ptrend < 0.05). FFM, FM%, and excess weight loss (EWL%) were significantly different between the two phenotypes (Pbetween < 0.05) during the follow‐up. Multivariate linear regression demonstrated that compared to MUSO patients, MHSO individuals experienced a greater increase in total weight loss (TWL%) and EWL% at 12‐ and 24‐month and in EWL% at 36‐month post‐surgery and also a lower decrease in the FFML/WL% after 12 months. Conclusion Despite a lower decrease of FFML/WL% and a greater increase in TWL and EWL in MHSO phenotype at some time points, there were no clinically significant differences between the study groups in terms of body composition changes throughout the follow‐up period.

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Body Composition Changes Following Sleeve Gastrectomy Vs. One-Anastomosis Gastric Bypass: Tehran Obesity Treatment Study (TOTS)

Cited by 11 publications

References 25 publications

Assessment of the Clinical Condition and Way of Patients’ Nutrition before and after Laparoscopic Sleeve Gastrectomy

Assessment of the Clinical Condition and Way of Patients’ Nutrition before and after Laparoscopic Sleeve Gastrectomy

Effect of Weight Regain on Body Composition and Metabolic Biomarkers After Sleeve Gastrectomy: a Cross-Sectional Study from a Hospital Database

Comparing Effects of Bariatric Surgery on Body Composition Changes in Metabolically Healthy and Metabolically Unhealthy Severely Obese Patients: Tehran Obesity Treatment Study (TOTS)

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